Dr.
Parthaprasad Chattopadhyay
Male
Affiliation
Professor
Department of
Biochemistry
Contact
Email :
parthoaiims@hotmail.com
Phone :
011-26549238
Address : Room No. 4007, Convergence Block, AIIMS, New Delhi.
EDUCATION
MBBS, (1981-1987) R G Kar Medical College, Calcutta University, Kolkata
MD, Biochemistry, (1989-1991) All India Institute of Medical Sciences, New Delhi.
PhD, Biochemistry (1992-1996) All India Institute of Medical Sciences, New Delhi.
PROFESSIONAL EXPERIENCE
Senior Demonstrator (1992-1995) Department of Biochemistry, AIIMS, New Delhi
Assistant Professor (1997-2003) Department of Biochemistry, AIIMS, New Delhi
Associate Professor (2003-2007) Department of Biochemistry, AIIMS, New Delhi
Additional Professor (2007-2011) Department of Biochemistry, AIIMS, New Delhi
Professor (2011- till date) Department of Biochemistry, AIIMS, New Delhi
Present Team
- PhD Students
- Neha Singh: Ritika Singh:
- MD student: Dr. Abhishek Mishra
Research Focus of the Lab
a) Nanoparticle trafficking within the cell: Tracing the path of nanoparticles within the cell and attempting to modulate their intracellular travel to prolong their stay within the cell for increased unloading of their cargo (drug).
b) Site-directed epigenetic modulation: Using modified CRISPR based techniques to modulate CpG methylation and Histone methylation/acetylation for altering gene expression of tumor suppressor and promoter genes
Strategic publications
- Passive internalization and active extrusion determines PLGA-nanoparticle concentration in cancer cell lines. Baidya G, Tiwary R, Mudassir M, Singh N, Saha S, Chosdol K, Sinha S, Chattopadhyay P..Nanomedicine (Lond). 2020 Aug;15(23):2229-2239.
- HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia by activating an Oct-4/Sox-2-Mena (INV) axis. Bhagat M, Palanichamy JK, Ramalingam P, Mudassir M, Irshad K, Chosdol K, Sarkar C, Seth P, Goswami S, Sinha S, Chattopadhyay P..Int J Biochem Cell Biol. 2016 May;74:60-71.
- A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting. Khan I, Zakaria MK, Kumar M, Mani P, Chattopadhyay P, Sarkar DP, Sinha S..J Transl Med. 2015 Aug 5;13:254.
- Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region. Kassab MA, Mudassir M, Singh A, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K, Sinha S, Chattopadhyay P..PLoS One. 2015 Jun 5;10(6):e0128416.
- Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing. Ramalingam P, Palanichamy JK, Singh A, Das P, Bhagat M, Kassab MA, Sinha S, Chattopadhyay P. RNA. 2014 Jan;20(1):76-87.
- Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells. Zakaria MK, Khan I, Mani P, Chattopadhyay P, Sarkar DP, Sinha S..BMC Cancer. 2014 Aug 10;14:582. doi: 10.1186/1471-2407-14-582.
- Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA. Singh A, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M, Andrabi R, Luthra K, Sinha S, Chattopadhyay P..J Antimicrob Chemother. 2014 Feb;69(2):404-15.
- CpG hypermethylation of the C-myc promoter by dsRNA results in growth suppression. Mehndiratta M, Palanichamy JK, Pal A, Bhagat M, Singh A, Sinha S, Chattopadhyay P..Mol Pharm. 2011 Dec 5;8(6):2302-9.
- Silencing of integrated human papillomavirus-16 oncogenes by small interfering RNA-mediated heterochromatization.Palanichamy JK, Mehndiratta M, Bhagat M, Ramalingam P, Das B, Das P, Sinha S, Chattopadhyay P..Mol Cancer Ther. 2010 Jul;9(7):2114-22.
- Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia. Pal A, Srivastava T, Sharma MK, Mehndiratta M, Das P, Sinha S, Chattopadhyay P..J Cell Mol Med. 2010 Nov;14(11):2646-54..
Funding Agencies
Department of Biotechnology and Department of Science & Technology, Ministry of Science & Technology, GOI.
Dr.
Shyam S. Chauhan
Male
Affiliation
Professor
Department of
Biochemistry
Contact
Email :
s_s_chauhan@hotmail.com
Dr.
Veena Koul
Female
PhD
Affiliation
Professor
Department of
Biomedical Engineering
Contact
Email :
veenak@cbme.iitd.ac.in
veenak_iitd@yahoo.com
Phone :
+91-11-2659-1041 (O)/6132/ 6396 (PA)
Dr.
Hemanga K. Bhattacharjee
Male
Affiliation
Professor
Department of
Surgical Disciplines
Units : III
Prof.
Anita Dhar
Female
Affiliation
Professor
Department of
Surgical Disciplines
Units : VI
Prof.
V.K. Bansal
Others
Affiliation
Professor
Department of
Surgical Disciplines
Units : IV
Prof.
Sandeep Aggarwal
Male
Affiliation
Professor
Department of
Surgical Disciplines
Contact
Email :
sandeep_aiims@yahoo.co.in
sandeep.aiims@aiims.edu
Units : II
Dr Sandeep Aggarwal, MS, FACS, FICLS, attended medical school at All India Institute of Medical Sciences (AIIMS), New Delhi and completed his surgical residency from AIIMS. He also completed a 1-year fellowship at Mount Sinai School of Medicine in New York, USA and a 4 month period in Homerton University, London, UK as a Commonwealth Fellow where he got trained in Bariatric Surgery. He has been a Faculty member in the Department of Surgical Disciplines at AIIMS since 1999 and is currently Professor of Surgery at AIIMS, New Delhi. He is an accomplished bariatric surgeon and developed a robust obesity surgery program at AIIMS in year 2008, the first public funded Institution in the Country to have such a program for Obese Population. Since then he has operated more than 1300 morbidly obese patients. He set up a dedicated bariatric surgery clinic for comprehensive care of obese patients. He is the Faculty in charge of a 2-year Bariatric Fellowship Program at AIIMS.
Dr Aggarwal is actively involved in research in the field of obesity, bariatric and metabolic surgery. His research interests include impact of Obesity Surgery on Non-Alcoholic Fatty Liver Disease (NAFLD), Obstructive sleep apnea and Type 2 Diabetes mellitus. He is also involved in collaborative research with department of Biochemistry at AIIMS. He is also evaluating impact of non-surgical management including pharmacologic treatment of obesity. He has authored numerous book chapters and published his research in high impact journals. Dr Aggarwal is the section editor of an internationally acclaimed book on Bariatric Surgery published by Springer, UK. He has delivered more than hundred national and international presentations on obesity and Bariatric Surgery as an invited faculty.
Dr Aggarwal is an active member of several scientific societies. He is the Founder President of Foundation for Obesity Research and Metabolic Surgery and has been a past executive member of Obesity and Metabolic Surgery Society of India (OSSI). He has organized several CMEs and conferences in this field. He is a member of AIIMS Institutional Ethics Committee for post-graduate research. He is widely recognized as a leader in the field of Obesity surgery and has helped start bariatric surgery at other Government institutions including PGI, Chandigarh, LNJP and LHMC hospitals besides training numerous surgeons. His future goals include setting up a dedicated Center of Excellence for Obesity and bariatric surgery at AIIMS for comprehensive care, training and high quality research in this field.
Pubmed ID – Publication
Orcid ID Sandeep Aggarwal (0000-0001-9540-0303)
Prof.
Anand Kumar
Male
Affiliation
Professor
Department of
Reproductive Biology
up to 2016
Prof.
M Rajalakshmi
Female
Affiliation
Professor
Department of
Reproductive Biology
up to 1998
Prof.
Vuthaluru Seenu
Male
Affiliation
Professor
Department of
Surgical Disciplines
Units : IV
