Dr. Sharma is an Additional Professor in the Department of Biochemistry and Posted in NCI-India/AIIMS Jhajjar Campus, AIIMS, New Delhi.He received Ph.D. in Cancer Biology at the Department of Biochemistry at All India Institute of Medical Sciences (AIIMS), New Delhi, in 2009. He is the recipient of multiple awards, including the prestigious “DBT-Ramalingaswami fellowship” and “DST-Ramanujan fellowship” awards from Govt. of India and “Outstanding Immunologist Award”, Immunocon, Indian Immunologist Society,  BHU.

In 2009, he joined the Vanderbilt Medical Center, Vanderbilt University, Nashville, TN USA as a postdoctoral fellow. He worked on tight junction proteins (claudins) and their role in regulating cell migration and epithelial-mesenchymal transition (EMT). In 2012, he joined the group of Adam R Karpf at Eppley Institute, UNMC, as a senior postdoc. He is working on the epigenetics & regulation of  Cancer-Testis/germline antigen POTE and its biomarkers/therapeutic potential. He has published multiple research articles and abstracts in national and international journals. He is actively involved in ePG-Pathshala, an MHRD, National Mission on Education through ICT (NME-ICT) venture to develop e-content at the postgraduate level that will help to improve the education system in India. Dr. Sharma has been the principal investigator and co-investigator in multiple projects for gynecological cancer. Dr. Sharma has been actively involved in establishing the “DBT-AIIMS/NCI-India Translational & Clinical Research Partnership Center” as PI with the help of DBT, GOI, and Early Detection Research Network (EDRN) at NCI-India with collaboration with EDRN-NCI-USA.

All India Institute of Medical Sciences (AIIMS), New Delhi, India

Education:

The University of Melbourne, Australia, Jun 2014

Advanced Certificate courses in “Epigenetic Control of Gene Expression."

This course addresses the basic principles of epigenetics, the role of epigenetics in biological phenomena such as imprinting, X-inactivation, cellular identity, cellular reprogramming in several organisms, and a focus on mammals. It also deciphers the interplay between epigenetic control and the environment, the role of aberrant epigenetic mechanisms in human diseases, and finally, the development of epigenetically effective drugs. The program's objective is to provide a solid foundation of information, enabling participants to design experiments when returning to their own research lab.

All India Institute of Medical Sciences (AIIMS), New Delhi, India

Ph.D. Department of Biochemistry, September 2008.

Thesis: Effect of Anticancer Agents on the Expression of High Mobility Group (HMG) Proteins in Skin Cancer”

Examined the mechanism of various anticancer agents like cisplatin, doxorubicin, Bleomycin through the expression of DNA binding high mobility group (HMGs) proteins in benzo(a)pyrene-induced squamous cell carcinoma of the skin.

I used various molecular and biochemical techniques, both In-vitro and In-vivo models, and basic microbiological and biochemical techniques and data corroborate with Magnetic Resonance Imaging in an animal model.

Results help in elucidation of the molecular mechanisms that mediate cisplatin. Doxorubicin resistance holds promise for the design of pharmacological strategies for preventing, overcoming, or reversing this form of drug resistance.

Maharshi Dayanand University, Rohtak, HR, India

Master of Science (M.Sc.) Specialization: Biochemistry, September 2001.

Dissertation: Effect of NaCl Salinity on Oxalate Metabolism in Shoot of Barley during Early Phase of Growth “. Results published in 'India Journal.'

Pt. B.D.S Post Graduate Institute of Medical Sciences, Rohtak, HR, India

• D. Pharmacy, September 1999. Concentration in ’Pharmacology & Toxicology’;Pharmaceutics; Pharmaceutical chemistry; Pharmaceutical Jurisprudence; ‘Drugs store & Business Management’ and ’Hospital & Clinical Pharmacy; along with three months training as an Apprentice Pharmacist in different departments at Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana. Participated in summer’s research program resulting in dissertation and presentation.
• Dissertation: Anti-dermatitis Potency of Stem Extract of Capparis deciduas

Positions Available:

Highly motivated and interested fellows and students are encouraged to inquire regarding the availability of research positions. We are seeking applications from motivated, goal-oriented individuals with excellent academic backgrounds and having their ownCSIR/DBT/ICMR/BINC/DST fellowships.Candidates with experience in Molecular Biology/Bioinformatics or other multidisciplinary are encouraged to contact and send their CV along with a cover letter at ashok[dot]sharma[at]aiims[dot]edu

Left to right: Dr.Shaikh Abdul Mubeen, Deepak Vats, Diravyaseelan M, Hema Yadav,Dr. Archana Singh, Dr. Sudhasini Panda, Alisha Arora, Faisal Shah

Academic Details:

Positions held:

Notable Awards and Society Memberships

Life member of the Association of the Medical Biochemist of India (AMBI), Association of the Clinical Biochemists of India (ACBI), Indian Society for Atherosclerosis Research (ISAR), Indian Immunology Society

• Executive Member of Indian Immunology society National body (2016-2022)
• Joint Secretary of Indian Immunology Society National body(2022- 2024)
• Trained on medical laboratories quality management system and Internal audit as per IS/ISO 15189 from National Institute of training for standardization, Bureau of Indian Standards, Noida, Delhi.
• Worked on various aspects of complicated pregnancy (Pre-eclampsia and IUGR) and has won three awards namely Dr. C Sita Devi Award for best paper twice at Association of Clinical biochemists of India in 2010 and 2013 and International Federation of Clinical Chemistry Roche Travel Scholarship to attend and present poster at Asian Pacific Federation of Clinical Biochemistry 2013, Bali, Indonesia.
• At present working in tuberculosis has got few awards won by Sudhasini Panda (PhD student) and Dr Ambrish Tiwari (MD student) which are as follows: Travel award to present paper at APFCB 2016, best paper at ACBI Delhi chapter 2016 and Dr P Usha Sharma best paper at ACBICON 2017. Won third price for AIIMS excellence Research Award 2019

Others

Involved as co-Investigator and Co-guide in other interdepartmental Extramural and Intramural projects and DM/Mch/PhD/MD/MS/MSc/MBBS thesis and research work.

Lab members (Current)

• Ms. Alisha Arora (PhD student)
• Mr. Deepak Vats (PhD student)
• Ms. Vidushi Sharma (MSc student)
• Dr. Shaikh Abdul Mubeen (Junior Resident)
• Mrs. Purnima Gola (Senior Laboratory Technologist)
• Karan (Lab Assistant)

Lab members (Alumni)

• Ambrish Tiwari (MD)
• Dr. Sudhasini Panda (PhD and MSc)

Current Affiliation: Postdoctoral fellow, La Jolla Institute for Immunology, San Diego, California

3, Dr. Diravyaseelan M (M.D)

Current Affiliation: Senior Resident, Department of Biochemistry, AIIMS, Delhi

4 Mr. Faisal Shah (MSc)

Current Affiliation: PhD Scholar, Friedrich-Loeffler-Institute, University of Griefswald, Griefswald, Germany

5 Ms. Hema Yadav (MSc)

Current Affiliation: PhD Scholar, Department of Biochemistry, AIIMS, Delhi

Interested in taking JRF/research trainees/ MBBS summer fellows as and when funds are available

Patient Care: Presently In - charge of clinical chemistry laboratory, Department of Biochemistry, All India Institute of Medical Sciences, Delhi. Is also in charge for porphyria testing in the department.

Students presently working in Laboratory

• Ms. Alisha Arora (PhD student)

Alisha completed her B.Sc.(H) in Zoology from Daulat Ram College, University of Delhi in 2017. She has completed her M.Sc. in Zoology from Hansraj College, University of Delhi in 2019. She qualified CSIR-UGC-JRF in 2017. Currently she is a third year PhD student under the guidance of Dr. Archana Singh. She is working on “Influence of different grades of hyperglycemia on innate immune responses in pathophysiology of active tuberculosis

2. Mr. Deepak Vats (PhD student)

Deepak completed his B.Sc. (H) in Zoology from Panjab University in 2017. He did his M.Sc. in Zoology from CCS Haryana Agricultural University in 2019. He qualified CSIR-NET-JRF in December 2020. Currently he is a second year PhD student under the guidance of Dr. Archana Singh. His PhD thesis is on “Study of immune response in TST (Tuberculin Skin Test) and IGRA (Interferon Gamma Release Assay) negative household contacts compared to latent TB infected household contacts of adult pulmonary tuberculosis patients

3. Ms. Vidushi Sharma (MSc student)

Vidushi completed her B.Sc.(H) in Biochemistry from Sri Venkateswara College, University of Delhi in 2021. She is the Delhi University Gold Medalist in the year 2021 for securing the highest marks in the B.Sc. (H) Biochemistry examinations. She had secured an All India Rank 1 in both AIIMS Biochemistry and Biotechnology entrance exams. She qualified GATE 2022 in both Biotechnology and Life Science. She is a first year M.Sc student and under the supervision of Dr. Archana Singh, she is working on her thesis titled “Study of Bdellovibrio bacteriovorus as a live antibiotic against Mycobacterium tuberculosis.”

4. Dr. Shaikh Abdul Mubeen (Junior Resident)

Dr. Mubeen did his MBBS from Government Medical College and Hospital, Aurangabad. Currently he is the first year M.D. student under the guidance of Dr. Archana Singh. His thesis is focused on the “Study of Immunophenotypes of monocyte subsets in TST and IGRA negative household contacts of adult pulmonary Tuberculosis Patients.”

ACADEMIC PROFILES:

PROFESSIONAL CAREER:

ACADEMIC PROFILE:

NOTABLE AWARDS:

• Best Poster Award, WCC 2018, Jaipur, India
• Best Poster presentation award, Drug Discovery and Development India 2015
• Second best poster award, Globin Switching meeting Asilomar CA 2008
  • Indian National Science Academy (INSA) young scientist award (2005) (Highest level national award for young scientist)
  • Best Postgraduate in Clinical research award in PhD, 2004
  • Best Oral presentation award, Indian Immunology Society meeting (2001)
  • Honour of Merit for University 1st Rank in Masters (MSc)
  • Endowment Award in MSc for best overall performance
  • Best Postgraduate Alumni Award (1995-1998) in Dept of Biochemistry, JIPMER, India
  • Qualified (1998,1999) {CSIR National Level Merit Exam for PhD fellowship}
  • Qualified for the state level lectureship examination for universities
  • Journal of Biomedical Sciences
  • Journal of Single Cell Biology (Omics publication group)
  • Annals of Clinical and Laboratory Research
  • BMC Bioinformatics
  • Journal of Clinical Pathology
  • Journal of Molecular Cell Biology
  • Chinese J of Cancer Research
  • Journal of Cancer Research and Therapeutics
  • Willey Science Advisor
  • Asian K Medical Science
  • Oncology Letters
  • J Med Archives
  • 1JMMD
  • PLoS One
  • World J of Surgical Oncology
  • Asian J of Reproductive Medicine
  • F1000

EDITORIAL ASSIGNMENTS:

LABORATORY PERSONNEL:

PhD scholars

MSc Student

Post Doc Fellows

Project Fellows

Lab technicians

Tryambak Pratap Srivastava

Tryambak is a final-year PhD scholar in Dr. Karmakar’s laboratory. He is working on elucidating the role of the Androgen Receptor in the pathogenesis of Breast Cancer. This prospective study is carried out simultaneously in cell lines and the subjects with breast cancer undergoing surgical interventions at AIIMS, New Delhi. His doctoral research is assisted by a group of basic scientists, pathologists, surgeons; medical, surgical, and laboratory oncologists. He remains grateful to the generous funding support from the ICMR, DHR, and SERB for laboratory funding and CSIR-UGC in terms of senior research fellowship.

Tryambak obtained his B.Sc. B.Ed. dual degrees from the Regional Institute of Education, Bhubaneswar, a constituent unit of NCERT, New Delhi. Following his graduation, he joined South Asian University (SAU), New Delhi for an M.Sc. in Biotechnology. In his masters’ dissertation, he checked the efficacy of a Pfizer drug against the HIV-1 subtype C.

Tryambak advocates open access to knowledge and information. An amateur linguist, he communicates his science, blogs, and thoughts on his website and Twitter. His profile, contact information, and other relevant details can be fetched from his website.

Sunil Kumar

Mr. Sunil Singh has completed his Bachelor’s in 2015 from Deshbandhu College, University of Delhi, New Delhi. After B.Sc. he joined All India Institute of Medical Sciences (AIIMS), New Delhi as master’s Student and completed it in 2017. During M.Sc. he did his thesis under the mentorship of Dr. Subhradip Karmakar on the “Role of Peroxisome Proliferator Activated Receptor alpha (PPAR-α) in Human Trophoblast Invasion”. In 2018 he joined Dr. Subhradip Karmakar, Asst. Professor, Dept. of Biochemistry, AIIMS, New Delhi as PhD student and has started his work on understanding the role of toxic pollutants such as Sulphur dioxide and Particulate matter on the trophoblast cells and thus pregnancy and placentation. A part of his research work also warrants to identify the

transgenerational effect of these pollutants on the fetal health and growth which would be achieved by performing RNA-Seq and ChIP-Seq followed by depth in-silico analysis and animal experiments. 

Dr Sajib Kumar Sarkar

Dr Sajib Kumar Sarkar (MBBS, MD, DNB) is a 4th year PhD scholar with Dr Karmakar. He did his MD in Biochemistry from MAMC, New Delhi. As a part of MD thesis he worked on in vitro and animal models of insulin resistance and observed the ameliorating effect of extract of Jamun (Syzigium cumini) seed. He completed 3 years of Senior Residency from department of Biochemistry, AIIMS, New Delhi. Presently he is exploring the molecular pathogenesis of gallbladder cancer with special focus on nuclear receptors.

Neha Kashyap

Ms. Neha Kashyap, first year Ph.D. Scholar has completed her Bachelors in Zoology Honours from “Ravenshaw University” Cuttack, Odisha. She has done her Masters in Life Sciences (Specialization in Biochemistry) from Central University of Punjab, Bhatinda. Her M.Sc. dissertation work was on the topic "miRNA mediated pathway modulation by phytochemicals: An In-silico approach" under the guidance of Dr. Shashank Kumar, Assistant Professor in the Department of Biochemistry. She got selected for the Indian Academy of Sciences “Summer Research Fellowship” project sponsored by the Indian Academy of Sciences, Bengaluru, during her graduation where she worked on the project "Analysis of Phytochemical constituents and amino acids present in green

seaweeds from South East Coast of India” under Dr.George Seghal Kiran,Assistant Professor in Pondicherry University. Later, she worked as a Junior Research Fellow (JRF) in Structural Parasitology lab, International Centre for Genetic Engineering and Biotechnology (I.C.G.E.B), New Delhi under eminent Principal Scientist Dr. Amit Sharma, Director of ICMR-NIMR in the Project "Development and validation of Hyponozite biomarkers for detecting Plasmodium vivax infection" .She also worked there on “Malarial culture and parasite proteins crystallography” .She qualified for ICMR-JRF 2020. Currently, she is working as a Ph.D. Scholar, under Dr. Subhradip Karmakar, Additional Professor in the Department of Biochemistry in All India Institute of Medical Sciences (AIIMS), New Delhi. She is working with the placenta group. Her tentative thesis is " Molecular insights into the chromatin dynamics and epigenetic changes during trophoblast fusion.”.

Lavanya Gupta

 Ms Lavanya Gupta has completed her Bachelors from Sri Venkateswara College, University of Delhi in the year 2018-2021. She has done a summer internship project on “Applications of Bioinformatics in Cardiovascular Disorders for Novel Therapeutics Design under ”SRI VENKATESWARA INTERNSHIP PROGRAM FOR RESEARCH IN

ACADEMICS(SRI-VIPRA 2020) “ which included: Identification of target receptors implicated in cardiovascular diseases , compilation of ligand libraries ,Study of ADMET properties for drug-likeness and Virtual screening by docking followed by evaluation of docking energy to find best hit. She has done ADD ON COURSE -

1)  “The Science of Stem cells “

2) "Fundamentals of Immunology: Innate Immunity and B-Cell Function"

3) "Understanding the Brain: The Neurobiology of Everyday Life An online course authorized by American Museum.

She was also involved in drug and development project (VISTAAR) , a science Popularisation Event organised by SVC .

Also, she was a part of mindspar ideathon event organised in Sri Venkateswara college, where she was awarded with the best presentation.

Currently, she is working as a Msc student, under Dr. Subhradip Karmakar, Additional Professor in the Department of Biochemistry in All India Institute of Medical Sciences (AIIMS), New Delhi. She is working with the placenta group. Her tentative thesis is "To study the role of estrogen regulated miRNA involved in the process of Human

Dr. Arnab Nayek

Dr. Arnab is working as a Research Associate (Bioinformatician), in the department of Biochemistry, All India Institute of Medical Sciences, New Delhi, under the guidance of Dr. Subhradip Karmakar, Additional Professor, Department of Biochemistry. He is associated with the transcriptomics (RNA-seq) data analysis from RNA sequencing data generated from the lab as well as publicly available data from the The Cancer Genome Atlas (TCGA) database, development of integrated pipelines for NGS data analysis etc. His research credentials supported with 13 publications in referred journals and his research interest includes Next generation sequencing (NGS) data analysis from human samples to improve the disease diagnosis for clinicians, development of integrated pipelines for

NGS data analysis, protein structure modelling, protein engineering, Molecular dynamics simulations.

Dr. Joyeeta Talukdar

Dr. Rashmi

Works on Cancer Research Related to Understand the Altruistic Mechanism and Metastasis. My focus is to understand the mechanism of cancer recurrence, and the complex biological systems that underlie its development. Further, if possible to identify new ways of treating the disease by taking a close-up look at the fundamental mechanisms at work within cells.

Dr. Rashmi Minocha has completed her Ph.D. in Biochemistry from the Ludwig Maximilian University of Munich (LMU), Germany. During the course of her Ph.D., she carried out her research work at the Gene Center, LMU Munich and at the Institute of Biochemistry, University of Gießen (Germany). The overall aim of her doctoral work was to understand how gene expression is regulated by the cross communication between its single steps using yeast as a model organism. Specifically, she worked on the biochemical and functional characterization of splicing proteins Mud2 and Prp19 complex (Prp19C).

After her Ph.D., she moved back to India and joined All India Institute

of Medical Sciences (AIIMS) in the Department of Biochemistry to pursue her interests in medical and health-based research. She is presently working as a Young Scientist Awardee (a fellowship and research grant funded by Department of Health Research). Her major research interests are:

• Establishment of three-dimensional spheroid and organoid culture systems as in vitro disease models.
• Using these pivotal model systems for understanding cancer pathogenesis, screening for potential drugs and investigating new strategies in the field of personalized medicine.
• Applying an interdisciplinary approach by using a combination of techniques from cancer biology, molecular biology, biochemistry and bioinformatics.

Her on-going focus is to apply these 3D culture systems to investigate into the molecular mechanisms which drive gallbladder carcinogenesis.

Indrani Mukherjee

Ms. Indrani Mukherjee completed her Bachelor’s degree from Bethune College, Kolkata, the oldest women’s college in Asia with first division in Zoology. She pursued her Master’s degree in Zoology with first class from Asutosh College, University of Calcutta. Ms. Indrani completed her research training during M.Sc on the “Role of nanocapsulated flavonoidal antioxidants in combating age related cerebral ischemia-reperfusion (CIR) induced oxidative injury in rat brain” under the guidance of Dr. Nirmalendu Das, Emeritus Scientist, CSIR-Indian Institute of Chemical Biology, Kolkata. She formulated nano-encapsulated antioxidants and applied them orally to Sprague Dawley rats as a pre-treatment prior to CIR insult. She studied the rat brains for histological examinations and

expression of cellular apoptotic factors. Later, she worked under the guidance of Dr. Parasuraman Jaisankar, Senior Principal Scientist, CSIR-Indian Institute of Chemical Biology, Kolkata, in two projects. One project was entitled “A molecular docking approach to study the possible interactions between Yeast 1,4-α glucosidase and some synthetic inhibitors” where she used molecular docking to analyse the interactions between various proteins and their ligands. The second project was entitled “Isolation of enzymes from natural resources” where she used column chromatography, thin layer chromatography and HPLC for the extraction and chemical purification of phosphatases from natural resources. Ms. Indrani then worked as a Project Fellow under the guidance of Dr. Shantanu Chowdhury, Senior Principal Scientist, Functional Genomics, CSIR-Institute of Genomics and Integrative Biology, New Delhi. She focussed on learning the basic molecular biology techniques. She was involved in the amplification of pGL3 basic vector in Stbl2 strain of E.coli and its transient transfection and analysis of protein expression profile in HT 1080 cells. Currently, she is working as a PhD student under the guidance of Dr. Subhradip Karmakar, Additional Professor, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi. She is a registered Ph.D scholar of Amity University, Noida, Uttar Pradesh. Her tentative thesis is entitled as “To Investigate the Role of Reactive Oxygen Species in Development of Pre-eclampsia”. Pre- eclampsia is a leading cause of maternal and neonatal mortality and morbidity and is usually diagnosed during the last trimester of pregnancy (after 20 weeks of gestation). During Pre-eclampsia, trophoblast cell migration and invasion into the maternal decidua, and vessels are typically incomplete, and thus angiogenesis and trophoblast cell proliferation are impaired. The shallow trophoblastic invasion induces placental ischemic reperfusion injury due to irregular uterine blood flow which results in the generation of reactive oxygen species (ROS). Therefore, her hypothesis is that excessive ROS generation along with an alteration of cytokine and hormonal levels in the uterine microenvironment, might contribute to the pathogenesis of Pre-eclampsia. Ms. Indrani was also awarded with CSIR-Senior Research Fellowship in the year 2019 and served as the Cultural Secretary of Society of Young Scientists (SYS), AIIMS, New Delhi, for the year 2020-2021.

Abhibroto Karmakar

Systemic Lupus Erythematosus is a chronic, autoimmune disease with wide clinical presentation. Lupus widely affects many organs and system with no cure. The main area of our study is understanding the genomic stratification and drug responds between the patients with lupus. We keen to explore the molecular aspect of patients during lupus flare and remission. We are also looking at single nucleotide polymorphism in SLE patients focusing on Indian population. Apart from my PhD we are looking at the role of nuclear receptor in pathogenesis of gall bladder cancer.

Apart from science I love teaching dance, recitation and writing poems. I love to do solo travelling and cooking give me zeal to life. I believe education is important for all in this regard I made an YouTube channel

creating medical awareness and do career counselling in field of life sciences.

Swati Ajmeriya

Aman Saifi

Swati Ajmeriya is working as Senior Research fellow at Department of Biochemistry, AIIMS under Dr. Subhradip Karmakar. She did her masters in Biotechnology. She does research in the area of genomics using bioinformatic tools and techniques. She has worked on high-throughput exome, transcriptome and metagenomics data. She has good command over linux scripting, R and python programming. She also develops pipelines for rapid processing of genomics data. Swati's research work is primarily involved in transcriptomics and statistical genomics with applications to the identification of differentially expressed genes and genetic variants conferring susceptibility to diseases by discovering variants, genes and pathways from high-throughput data.  

Mr Aman Saifi is working as a Junior Research Fellow on a project called "Molecular Analysis to explore resistance against receptor tyrosine kinase inhibitors (RTKI) in Renal Cell Carcinoma (RCC) and the prognostic role of circulating tumour cells in patients with metastatic RCC (mRCC). He has completed his Bachelor's and Master's Integrated Degree in Biotechnology from Amity University, Uttar Pradesh. He qualified GATE exam in 2021 as well as in 2022. His university awarded him a merit scholarship during his coursework. He was selected for the summer internship program at Jawaharlal Nehru University. He worked on the project "standardizing the IR64 rice seeds tissue culture protocol for the plant transformation with Agrobacterium tumefaciens harbouring  pCAMBIA1304 vector". Later, for his master's thesis, he worked on the project "standardization of differentiation of bone cell precursors (macrophages and mesenchymal stem cells) into mature bone cells (osteoclast and osteoblast cells)" in the department of Biotechnology, AIIMS

ALUMNI:

EDUCATION

MBBS, Medicine and Surgery (2000-2006)

Government Stanley Medical College,

Chennai, Tamilnadu

MD, Biochemistry, (2007-2010)

All India Institute of Medical Sciences (AIIMS), New Delhi.

PROFESSIONAL EXPERIENCE

Senior Demonstrator (2010-2012)

Department of Biochemistry, AIIMS, New Delhi

Postdoctoral Research Fellowship (2012-2014)

Department of Pathology and Lab Medicine

David Geffen School of Medicine at UCLA, Los Angeles, California

Assistant Professor (2014-2017)

Department of Biochemistry, AIIMS, New Delhi

Associate Professor (2017-2020)

Department of Biochemistry, AIIMS, New Delhi

Additional Professor (2020-Present)

Department of Biochemistry, AIIMS, New Delhi

Our Team

• Scientists and Postdoctoral Fellows
• Dr Kriti Kaushik: Postdoctoral Research Fellow (DHR Young Scientist-III). Kriti joined the lab as a DBT-Research Associate (fellowship) in 2018 with an interest to decipher the role of long non-coding RNAs in regulating IGF2BP3 in aggressive cancers. She has expanded her research investigation as a DHR Young Scientist to study another class of non-coding RNAs i.e. circular RNAs bound with IGF2BP3 and their mechanism of action in promoting metastasis during hypoxia in leukemia patients. With a strong background in genomics (during her PhD from CSIR-IGIB), Kriti also works on bioinformatic analysis of RNA-seq and related data.
• Dr Sumedha Saluja: Sumedha is an ICMR project scientist-I. She joined the lab in March 2018 and did her PhD in the lab. She is currently investigating the role of epitranscriptome and IGF2BP family of RNA-Binding Proteins in B-cell Acute Lymphoblastic Leukemia. She has a Masters in Biochemistry from AIIMS with a thesis focussed on stem cells and cancer. During her MSc, she was awarded with UGC Postgraduate Merit Scholarship for University Rank Holder and she was a University Gold Medalist in Biomedical Sciences.
• Dr Sivapar Mathan: Mathan is an ICMR project scientist-II. He is working on using CRISPR screens to rapidly identify therapeutic vulnerabilities in B-ALL.
• Tejaswini Choudhury: Tejaswini is an ICMR project scientist-I. She is working on the role of various immune cell subsets in liver transplant rejection and on creating synthetic circuits to identify intracellular signals.
• Graduate Students
• Ishu Bansal: Ishu is a fourth year PhD student and ICMR-SRF. She joined the lab in May 2021. She is investigating the role of IGF2BP family of RNA-Binding Proteins in modulating the PI3K pathway in B-cell Acute Lymphoblastic Leukemia.
• Mohammad Sabique Beg: Sabique is a fourth year PhD student and DBT-SRF. He joined the lab in May 2021. He is working on using CRISPR directed therapies to silence IGF2BP3 in cancer cell lines.
• Ruchi Bhardwaj: Is a second year PhD student and a DBT-JRF. She joined the lab as a graduate student in March 2023. She works on identifying gene networks perturbed by m6A modifications in B-ALL.
• Tanu Bansal: Is a second year PhD student and a DBT-JRF. She joined the lab as a graduate student in March 2023. She works on designing synthetic circuits to target relapse specific genes in B-ALL.
• Senior Resident: Dr Sharath is a senior resident who joined the lab in Feb 2021. He works on deciphering the synergism between epitranscriptomic modifications and IGF2BPs in the stability of mRNAs. He also works on developing CRISPR directed AAV based therapies for Gaucher’s disease
• Project Associate-I: Anjli Gaur is a DHR project associate and is working on the identifying the role of relapse specific genes in B-ALL.
• Nitesh: Lab technician who helps in patient sample collection, processing and data collation

Alumni:

• Dr. Elza Boby: Elza was a Junior resident in the Biochemistry Department (2015-2018). Elza worked on the ‘Role of IGF2BP1 in ETV6-RUNX1 translocation positive B-ALL’ as part of her dissertation in our lab. She is presently working at Calicut Medical College in the Department of Biochemistry as Assistant Professor.
• Sanjeev Goswami: Sanjeev worked on the ‘Role of IGF2BP3 in the invasion and migration of cancer cells’ during his Masters in Biochemistry (2016-2018) in our lab. He is presently enrolled as a PhD student in Prof Kunzang Chosdol’s lab in Biochemistry at AIIMS, New Delhi.
• Dr Thakur Nidhi: Nidhi was a Junior Resident in the Biochemistry Department (2016-2019) Nidhi worked on the ‘Role of EGFL7 in ETV6-RUNX1 translocation positive B-ALL’ as part of her dissertation. She is presently working as a Senior Resident at ESIC, Faridabad.
• Harsh Bhakhri: Harsh worked on ‘The role of METTL3 and IGF2BP synergism in leukemogenesis’ during his Masters in Biochemistry (2019-2021) in our lab. He is presently enrolled as a PhD student in Prof Kalpana Luthra’s lab in Biochemistry at AIIMS, New Delhi.
• Arjun Saraswat and Lajja Patel: Arjun and Lajja were MBBS students who had been selected by the institute’s UG Mentorship Research Scheme. They worked on the role of IGF2BP3 associated circular RNAs in hypoxia and epithelial to mesenchymal transition.
• Dr Gunjan Sharma: Gunjan was the first PhD student from the lab. She worked on elucidating the role of IGF2BP1 in ETV6-RUNX1 translocation positive pediatric patients. She was a DBT-JRF/SRF and a winner of the SERB overseas visiting doctoral fellowship. She is presently a postdoctoral fellow at UCLA.
• Hemant Kumar: Hemant was a Masters student in the lab. He did his dissertation on the role of circRNAs in hypoxia. He is currently a PhD student in PGIMER, Chandigarh
• Diya Chawla: Diya was a Masters student in the lab. Her dissertation involved the development of a monocyte derived macrophage model for Gaucher’s disease.
• Mahek Farhan: Mahek was a Masters student in the lab. She worked on designing an RNA targeted CRISPR based strategy to reverse the phenotype in Gaucher’s disease
• Nisha Kushwaha: Nisha was a Masters student in the lab. She worked on validating the expression of relapse specific genes in a large cohort of archival patient samples.

Positions Available

We are always on the lookout for excellent postdoctoral/graduate students. If you are interested in the type of work which we do and have an idea which you wish to work on, please drop an email to drjayanth[at]aiims[dot]edu.

MBBS students for summer fellowships and short-term training are always welcome if you are willing to put in the hard work

Academic Details:

Positions held:

Society Memberships:

1. Life Member of the Society for Mitochondrial Research and Medicine, India.

2. Life Member, Indian Association for Cancer Research.

3. Life Member of Immunology Society of India.

4. Life member of Association of Medical Biochemists of India

List of Lab members

• Dr.Bhanupriya Awasthi, Postdoctoral Fellow.
• Ms. Sakshi Shukla, Doctoral student.
• Dr.Anudeep P P, Senior demonstrator (Not in pic).
• Dr.Laxmi Pillai, Junior Resident, (Not in pic).
• Ms. Bindiya Jindal, M.Sc. student.
• Ms.Shikha Roy, M.Sc. student.
• Adeeba Malik, Junior Research Fellow.
• Dr. Abishek G, MD student (not in pic).
• Ms. Dolly Rathore, Laboratory Technician.
• Mr.Mudassir Ali, Laboratory Technician.
• Mr.Ram Vikas Yadav, Laboratory Technician.
• Mr.Nidhi Bailwal, Laboratory Technician.
• Megha Suresh, Nutrition Research Associate.
• Sabiha Khan, Senior Nutrition Research Fellow.

Positions Available: Expected in January 2024.

Academic Details :

Positions held

Notable Awards and Society Memberships:

• Member of National Academy of Medical Sciences (MNAMS) 2014.
• Member of
• (a) Society for Neurosciences (SfN)
• (b) Federation of European Neuroscience Societies (FENS)
• (c) International Society for Stem Cell Research (ISSCR)
• (d) Indian Academy of Neurosciences (IAN)
• (e) Indian Association for Cancer Research (IACR)
• (f) AMBI and ACBI
• (g) Delhi Medical Association

List of Lab members:

Currently enrolled Ph.D. scholars:

• Mr. Sagar Tyagi, MSc
• Dr. Vadanya Shrivastava, MD

M.D. student:

• Dr. Rajkumar Mandal
• Dr. Sona Fazil

Staff:

• Mrs. Amrita Sachdeva (Admn.)
• Mr. Pramod Kumar (Lab attendant)
• Mr. Avdesh Kumar (Project staff)

Lab alumni:

• Dr. Janvie Manhas, MD, PhD
• Dr. Devanjan Dey, PhD
• Dr. Aditi Bhattacharya, PhD
• Dr. Amarpreet Kaur, MD, PhD
• Dr. Sandeep K. Agrawal, MD
• Dr. Janvie Manhas, MD
• Dr. Pradeep Jingar, MD
• Dr. Vadanya Shrivastava, MD
• Dr. Pawan Pagaku
• Ms. Nupur Khera, MSc
• Ms. Sumedha Saluja, MSc
• Ms. Diksha Joshi, MSc
• Ms. Sweety Rani Goyal, MSc

Positions Available: Contact by email to get the latest information.

Address: Room no 4007,

4^th Floor, Convergence Block,

Department of Biochemistry,

All India Institute of medical Sciences, New Delhi

Academic Details

Positions held:

Notable Awards and Society Memberships

• AIIMS Excellence Research Award- 2015 (3^rd Prize) in recognition of the outstanding publication “A combined gene signature of hypoxia and Notch pathway in human glioblastoma and its prognostic relevance”
• ISNO Presidents Award -2014 for the best Clinician Researcher in Basic Neuro-Oncology, awarded during 6^th Annual Conference of the Indian Society of neuro-Oncology (11-13 April, 2014) at Lucknow.
• AIIMS Excellence Research Award-2013(Third prize) in recognition of the outstanding publication “FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells”.
• DSTFAST TRACK Scheme for Young Scientist: 2010 and 2003.
• International Travel Grant from AIIMS to present my work in conference -IXth European Congress of Neuropathology, Greece. May, 2008
• INSA (Indian National Science Academy) Travel Support to attend the conference -IXth European Congress of Neuropathology, Greece. May, 2008
• Travel Fellowship by the MNBWS organizers (USA) to present my work during symposium - MNBWS; 50 years on: From the Double helix to Molecular Medicine, Miami, Florida. 2003.
• CSIR International Travel Grant to present my work in a symposium - MNBWS; 50 years on: From the Double helix to Molecular Medicine, Miami, Florida. 2003.

Patents:

1. Indian Patent Application No. 1400/DEL/2013: Sinha S, Khan I, Zakaria MK, Chosdol K, Chattopadhyay P for the invention entitled “Placental like Alkaline Phosphatase (PLAP) Promoter Mediated Cell Targeting”

2. Indian patent, PCT-1282 (PCT/IB2013/05008): Chosdol K, Dikshit B and Sinha S: For the “Use of FAT1 gene and its products including RNA, protein and the derivatives of the same, as suitable molecules for either inflammation or cancer and the associated phenotype and the processes linking the same and also as a biomarker for the above processes”. International patent filed, PCT in process.

Society Memberships:

• National Academy of Medical Sciences (NAMS)
• Indian Association for Cancer Research (IACR)
• Vice-President (2016-2018)
• ― Treasurer (2014-2016)
• Indian Society for NeuroOncology (ISNO)
• Association of Clinical Biochemists of India (ACBI)
• Society for NeuroChemistry India (SNCI)

1.Dr. Khushboo Irshad, PhD - DST-SERB Young Scientist

Dr. Khushboo Irshad completed her PhD at the Department of Biochemistry, AIIMS, New Delhi, in 2013 under the supervision of Prof. Kunzang Chosdol, Prof. Subrata Sinha and Prof. P. Chattopadhyay. Her thesis involved the study of correlation between hypoxia and Notch signaling pathway in glioblastoma and identification of a combined gene signature to predict the survival of glioblastoma patients. Her work derived a key prognostic molecular cluster characteristic of the Notch pathway response in hypoxic glioblastoma tumors and gliomasphere cultures (PLoS One (2015); 10(3):e0118201; felicitated with AIIMS Excellence Research Award-2015 that was awarded to Prof. Chosdol). Presently, her research focuses on deciphering the role of FAT1, a novel gene implicated in glioma, in regulating the hallmark features of glioma like stemness and invasiveness, as well as in maintenance of the balance between pro-inflammatory and anti-inflammatory signaling in glioma. She was awarded the DST-SERB Start-Up Research Grant in March 2016, for the project aimed at elucidation of FAT1 function in modulating pro-inflammatory signaling and anti-inflammatory / immunosuppressive signaling pathways in glioma.

2.Dr. SRINIVAS H, MD,DNB (PhD)

Dr. Srinivas H done MBBS from Bangalore Medical college, Rajiv gandhi university of health sciences Karnataka and MD from MAULANA AZAD Medical College, Delhi university, New Delhi. His MD thesis was on procalcitonin, IL 6, TNFalpha and urinary isoprostane in sepsis patients under the guidance of ex HOD and director professor Dr TK Mishra. He has completed one year of senior residency in PGIMER, Chandigarh and two year of senior residency in AIIMS, New Delhi. He has published his work in national and international papers in the various field of sciences and medical education. He is working now on pathway analysis of interaction between FAT1 with p53, HIF 1alpha and beta catenin in glioma as a PhD research scholar under the guidance of Dr KUNZANG CHOSDOL and Dr SUBRATA SINHA. He has done DNB from Diplomate of National Board in biochemistry and certification course in industry program, clinical trials and administration from bioinformatics institute of India. He is a Life member of Association of Medical Biochemistry of India since 2008

Life member of Society for Tissue Engineering and Regenerative Medicine (India), Thiruvananthapuram since 2010 and Indian Association of Cancer Research.

3.Ms. Chitrangda Srivastava - PhD scholar

Ms. Chitrangda Srivastava is currently in her final year of PhD. She is working on the characterization of FAT1 gene promoter. In addition, she is analyzing the functional role of FAT1 with EMT and stemness in hypoxic glioma. She completed her M.Sc. from the department of Biochemistry, AIIMS, in 2012. Her M.Sc. thesis involved the study of the role of Notch signalling pathway with EMT and stemness in pathogenesis of glioma under hypoxia. She has won several awards during her PhD tenure, including Best Oral Presentation Award in ACOS-2016, European Young Scientist Travel Award-2015, G.P. Talwar Foundation Travel Award-2015, etc. She is an Associate Member of the American Association of Cancer Research since 2011 and an Associate Member of the European Society of Neuro-Oncology since 2016.

4.Nargis Malik, PhD. Scholar

Nargis Malik completed her M.Sc. in toxicology from Meerut University, Currently she is a second year PhD. student working on the “Role of FAT1 gene on the regulation of microRNAs in glioma”

5.Ms. AKANKSHA KANOJIA, M.Sc. student

Akanksha Kanojia has completed her B.Sc.(H) in Biomedical Sciences from Acharya Narendra Dev College, University of Delhi in 2016. She is currently pursuing M.Sc. in Biochemistry from All India Institute of Medical Science, Delhi under the guidance of Dr. Kunzang Chosdol.

Mukesh Kumar (Laboratory Attendant Gr. II)

Mukesh Kumar is working as a Laboratory Attendant Gr.-II in the Department of Biochemistry since August 2011. He help in the research related work for M.Sc., Ph.D. and M.D. Students in Research Laboratory of Dr. Parthaprasad Chattopadhyay & Dr. Kunzang Chosdol. His nature of duties includes, culture work, DEPC treatment and assistance of UG/PG examination.

Address : Room No. 4007, Convergence Block, AIIMS, New Delhi.

EDUCATION

MBBS, (1981-1987) R G Kar Medical College, Calcutta University, Kolkata

MD, Biochemistry, (1989-1991) All India Institute of Medical Sciences, New Delhi.

PhD, Biochemistry (1992-1996) All India Institute of Medical Sciences, New Delhi.

PROFESSIONAL EXPERIENCE

Senior Demonstrator (1992-1995) Department of Biochemistry, AIIMS, New Delhi

Assistant Professor (1997-2003) Department of Biochemistry, AIIMS, New Delhi

Associate Professor (2003-2007) Department of Biochemistry, AIIMS, New Delhi

Additional Professor (2007-2011) Department of Biochemistry, AIIMS, New Delhi

Professor (2011- till date) Department of Biochemistry, AIIMS, New Delhi

Present Team

• PhD Students
  • Neha Singh: Ritika Singh:
• MD student: Dr. Abhishek Mishra