Selected Publications/Patents (Last 5 years):

• Koley T, Goswami A, Kumar M, Upadhyay N, Hariprasad G*. Comparative structural analysis of human ACE2 receptor with spike protein of SARS-CoV-2 variants: Implications to understand infectivity of the virus. Advances and Applications in Bioinformatics and Chemistry (2022) 15: 21-27.
• Kaushik A , Bandyopadhyay S, Porwal C, Srinivasan A, Rukmangadachar LA, Hariprasad G, Kola S, Kataria J, Singh UB. 2D-DIGE based urinary proteomics and functional enrichment studies to reveal novel Mycobacterium tuberculosis and human protein biomarker candidates for pulmonary tuberculosis Biochemistry Biophysics Research Communications (2022) 619:15-21.
• Pathania S, Khan MI, Bandyopadhyay S, Singh SS, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Vanamail P, Hariprasad G*. iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer. Scientific Reports (2022) 12(1):8625.
• Koley T, Kumar M, Goswami A, Ethayathulla AS, Hariprasad G*. Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virus. Biochemical and Biophysics Research Communications. (2022) 592:51-53.
• Naqvi AAT, Fatima K, Mohammad T, Fatima U, Singh IK, Singh A, Atif SM, Hariprasad G, Hasan GM, Hassan MI. Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach. BBA Molecular Basis of Disease (2020) 1866: 165878.
• Khan MI, Hariprasad G*. Structural Modeling of Wild and Mutant Forms of Human Plasma Platelet Activating Factor-Acetyl Hydrolase Enzyme. Journal of Inflammation Research. (2020) 13:1125-1139.
• Khan MI, Hariprasad G*. Human Secretary Phospholipase A2 Mutations and Their Clinical Implications. Journal of Inflammation Research. (2020) 13: 551-561.
• Patania S, Khan MI, Kumar A, Gupta AK, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Hariprasad G*. Proteomics of sentinel lymph nodes in early breast cancer for identification of thymidylate synthase as a potential biomarker to flag metastasis: A preliminary study. Cancer Management and Research (2020) 12: 4841–4854.
• Gupta AK, Pokhriyal R, Das U, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in CSF to monitor pharmaco-therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2073-2085.
• Gupta AK, Pokhriyal R, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Cerebrospinal fluid proteomics for identification of α2-macroglobulin as a potential biomarker to monitor pharmacological therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2853-2867.
• Gupta AK, Kumar GK, Rani K, Pokhriyal R, Khan MI, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Mohanty AK, Hariprasad. G*. 2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine dictated states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15: 1031-1044.
• Gupta AK, Rani K, Swarnkar S, Kumar GK, Khan MI, Pokhriyal R, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Hariprasad G*. Evaluation of Serum Apolipoprotein E as a Potential Biomarker for Pharmacological Therapeutic Efficacy Monitoring in Dopamine Dictated Disease Spectrum of Schizophrenia and Parkinson's disease: A Preliminary Study. J Cent Nerv Syst Dis. (2018) 10:1179573518803585. eCollection.

Selected Publications/Patents (Last 5 years):

• Ahmad N, Singh A, Gupta A, Pant P, Singh TP, Sharma S, Sharma P. Discovery of the Lead Molecules Targeting the First Step of the Histidine Biosynthesis Pathway of Acinetobacter baumannii. J Chem Inf Model. (2022) 62:1744-1759.
• Smith ML, Sharma S, Singh TP. Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection. Scand J Immunol. (2022) 95:e13111.
• Sikarwar J, Singh J, Singh TP, Sharma P, Sharma S. The mechanism of action of Lactoferrin - Nucleoside Diphosphate Kinase complex in combating biofilm formation. Protein Pept Lett. (2022) Aug 16. doi: 10.2174/0929866529666220816160517.
• Singh PK, Ahmad N, Yamini S, Singh RP, Singh AK, Sharma P, Smith ML, Sharma S, Singh TP. Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase. Protein Sci. (2022) 31:384-395.
• Singh J, Maurya A, Singh PK, Viswanathan V, Ahmad MI, Sharma P, Sharma S, Singh TP. A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 Å Resolution. Protein J. (2021) 40:857-866.
• Smith, M. L., Sharma, S., & Singh, T. P. Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections. Eur. J. Clin. Nutr. (2022). 1–2. 76(4):629-630.
• Gupta A, Vijayan V, Pant P, Kaur P, Singh TP, Sharma P, Sharma S. Structure prediction and discovery of inhibitors against phosphopantothenoyl cysteine synthetase of Acinetobacter baumannii. J Biomol Struct Dyn. (2021) Aug 4:1-13
• Singh A, Ahmad N, Varadarajan A, Vikram N, Singh TP, Sharma S, Sharma P. Lactoferrin, a potential iron-chelator as an adjunct treatment for mucormycosis - A comprehensive review. Int J Biol Macromol. (2021) Sep 30;187:988-998.
• Singh J, Vijayan V, Ahmedi S, Pant P, Manzoor N, Singh TP, Sharma P, Sharma S. Lactosmart: A Novel Therapeutic Molecule for Antimicrobial Defense. Front Microbiol. (2021) 12:672589.
• Gupta A, Sharma P, Singh TP & Sharma S. Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochim Biophys Acta Proteins Proteom (2021) 1869:140566.
• Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S & Singh TP Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Protein J. (2021) 40:8-18.
• Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S & Singh TP. Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution. J Biol Inorg Chem (2021) 26: 149-159
• Sharma P, Singla A, Gupta A, Khan NI, Rani C, Singh TP & Sharma S. Biophysical characterization of Type III Pantothenate kinase (PanK) from Acinetobacter baumannii. Protein Pept Lett (2021) 28(4), 450-458.
• Sharma P, Vijayan V, Pant P, Sharma M, Vikram N, Kaur P, Singh TP, Sharma S. Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2. J Biomol Struct Dyn. 2020; 3:1-11
• Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP. Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. (2019) 1867:537-547.
• Pandey SN, Iqbal N, Singh PK, Rastogi N, Kaur P, Sharma S & Singh TP. Binding and structural studies of the complexes of type 1 ribosome inactivating protein from Momordica balsamina with uracil and uridine. Proteins. (2019) 87:99-109.
• Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S & Singh TP. A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. (2018) 644:72-80
• Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Kaur P, Sharma S & Singh TP. Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J. (2018) 475:547-560.
• Singh PK, Iqbal N, Sirohi HV, Bairagya HR, Kaur P, Sharma S & Singh TP. Structural basis of activation of mammalian heme peroxidases. Prog Biophys Mol Biol. (2018)133:49-55.
• Singh PK, Sirohi HV, Iqbal N, Tiwari P, Kaur P, Sharma S, Singh TP. Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution. Biochim Biophys Acta. (2017) 1865:329-335.
• Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP. Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol. (2017) 94:459-465.
• Khan SH, Islam A, Hassan MI, Sharma S, Singh TP, Ahmad F.Effect of conservative mutations (L94V and L94I) on the structure and stability of horse cytochrome c. Arch Biochem Biophys. (2017) 633:40-49
• Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP. Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. (2017) 85:1882-1890.
• Singh RP, Singh A, Sirohi HV, Singh AK, Kaur P, Sharma S, Singh TP. Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases - structural determination of the lactoperoxidase-methimazole complex at 1.97 Å resolution. FEBS Open Bio. (2016) 6:640-50.
• Rastogi N, Singh A, Singh PK, Tyagi TK, Pandey S, Shin K, Kaur P, Sharma S, Singh TP. Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination. Proteins. (2016) 84:591-9.

List of Books:

• Warriors in White (11 January 2021). ISBN 978-1-637455-11-1.
• A Dragonfly's Purpose. (12 September 2019). ISBN 978-1-64650-765-8.
• The Secret of the Red Crystals. (16 October 2017). ISBN 978-1-947988-83-5
• Kovi’s Promise (21 November 2021) ISBN 979-8-885037-77-8
• Tumhara Bholu (23 November 2021) ISBN 979-8-885039-02-4

Publications:

• Gupta D, Tiwari P, Haque MA, Sachdeva E, Hassan MI, Ethayathulla AS, Kaur P. (2021) Structural insights into the transient closed conformation and pH dependent ATPase activity of S.Typhi Gyrase B N- terminal domain. Arch Biochem Biophys. Apr 15; 701:108786. doi: 10.1016/j.abb.2021.108786.
• Gupta D, Sharma P, Singh M, Kumar M, Ethayathulla AS, Kaur P. (2021) Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants. Cell Mol Life Sci. 78:7967-7989. doi: 10.1007/s00018-021-04008-0. (Review)
• Tripathi MK, Nath A, Singh TP, Ethayathulla AS, Kaur P (2021) Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery Mol Divers 25(3):1439-1460. doi: 10.1007/s11030-021-10256-w.
• Katiyar A, Kaur G, Rani L, Jena L, Singh H, Kumar L, Sharma A, Kaur P*, Gupta R*. (2021) Genome-wide identification of potential biomarkers in multiple myeloma using meta-analysis of mRNA and miRNA expression data. Sci Rep. 11(1):10957. doi: 10.1038/s41598-021-90424-y. (Co-Corresponding authors)
• Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S, Singh TP (2021) Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution. J Biol Inorg Chem. 26(1):149-159. doi: 10.1007/s00775-020-01844-6.
• Singh PK, Sharma P, Bhushan A, Kaur P, Sharma S, Singh TP. (2021) Structure of a ternary complex of lactoperoxidase with iodide and hydrogen peroxide at 1.77 Å resolution. J Inorg Biochem. 220:111461. doi: 10.1016/j.jinorgbio.2021.111461.
• Sharma P, Vijayan V, Pant P., Vikram N, Kaur P, Singh, TP, Sharma S (2021) Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2. J. Biomol Struct Dyn 39(17):6649-6659.
• Vijayan V, Pant P., Vikram N, Kaur P, Singh, TP, Sharma S, Sharma P (2021) Identification of promising drug candidates against NSP16 of SARS-CoV-2 through computational drug repurposing study. J. Biomol Struct Dyn 39(17):6713-6727.
• Gupta A, Vijayan V, Pant P., Kaur P, Singh, TP, Sharma P, Sharma S (2021) Structure prediction and discovery of inhibitors against phosphopanthothenoyl cysteine synthetase of Acinetobacter baumannii. J. Biomol Struct Dyn Aug 4:1-13.
• Singh M, Malhotra L, Haque MA, Kumar M, Tikhomirov A, Litvinova V, Korolev AM, Ethayathulla AS, Das U, Shchekotikhin AE, Kaur P. (2021) Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B. Biochimie. 182:152-165. doi: 10.1016/j.biochi.2020.12.024.
• Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP. (2021) Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Protein J. 40: 8-18. doi: 10.1007/s10930-020-09957-2. .PMID: 33389415
• Koley T, Madaan S, Chowdhury SR, Kumar M, Kaur P, Singh TP, Ethayathulla AS. (2021) Structural analysis of COVID-19 spike protein in recognizing the ACE2 receptor of different mammalian species and its susceptibility to viral infection. 3 Biotech.11(2):109. doi: 10.1007/s13205-020-02599-2. Epub 2021 Feb 1.PMID: 33552834
• Malhotra L, Goyal HKV, Jhuria S, Dev K, Kumar S, Kumar M, Kaur P, Ethayathulla AS. (2021) Curcumin rescue p53Y220C in BxPC-3 pancreatic adenocarcinomas cell line: Evidence-based on computational, biophysical, and in vivo studies. Biochim Biophys Acta Gen Subj. 1865:129807. doi: 10.1016/j.bbagen.2020.129807.
• Gupta A, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP. (2020) Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A. Int J Biol Macromol. 142:181-190. doi: 10.1016/j.ijbiomac.2019.09.090.
• Gupta A, Rani C, Pant P, Vijayan V, Vikram N, Kaur P, Singh TP, Sharma S, Sharma P. (2020) Structure-Based Virtual Screening and Biochemical Validation to Discover a Potential Inhibitor of the SARS-CoV-2 Main Protease.ACS Omega. 5:33151-33161. doi: 10.1021/acsomega.0c04808.
• Naz F, Mashkoor M, Sharma P, Haque MA, Kapil A, Kumar M, Kaur P, Abdul Samath E. (2020) Drug repurposing approach to target FtsZ cell division protein from Salmonella Typhi. Int J Biol Macromol. 159:1073-1083. doi: 10.1016/j.ijbiomac.2020.05.063.
• Sachdeva, E., Kaur, G., Tiwari, P., Gupta, D, Singh TP, Ethayathulla, AS, Kaur P. (2020). The pivot point arginines identified in the β-pinwheel structure of C-terminal domain from Salmonella Typhi DNA Gyrase A subunit. Sci Rep 10, 7817 https://doi.org/10.1038/s41598-020-64792-w
• Tripathi MK, Singh P, Sharma S, Singh TP, Ethayathulla AS, Kaur P (2020) Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor J. Biomol Struc. Dyn. doi.org/10.1080/07391102.2020.1790425
• Katiyar A, Sharma P, Dahiya S, Singh H, Kapil A, Kaur P (2020) Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India. Sci. Rep. 10:8299. doi: 10.1038/s41598-020-64934-0.
• Sharma P, Vijayan V , Pant P, Sharma M, Vikram N, Kaur P, Singh TP, Sharma S (2020) Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2 J. Biomol Struc. Dyn. doi.org/10.1080/07391102.2020.1798286
• Bansal R Haque MA, Hassan MI, Ethayathulla AS, Kaur P. (2020) Structural and conformational behavior of MurE ligase from Salmonella enterica serovar Typhi at different temperature and pH conditions Int J Biol Macromol. 150:389-399. doi: 10.1016/j.ijbiomac.2020.01.306
• Tiwari A, Kumar M, Kaur P, Kumar B, Sagi SSK (2020) Efficacy of Quercetin as a potent sensitizer of β2 AR in combating the impairment of fluid clearance in lungs of rats under hypoxia. Respiratory Physiology & Neurobiology 273: 103334
• Verma D, Gupta S, Saxena R, Kaur P, Srivastava S, Gupta V. (2020) Allosteric inhibition and kinetic characterization of Klebsiella pneumoniae CysE: An emerging drug target. Int J Biol Macromol. 151:1240‐1249. doi:10.1016/j.ijbiomac.2019.10.170
• Kumar A, Jain V, Chowdhury MR, Kumar M, Kaur P, Kabra M. (2020) Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature. J Pediatr Endocrinol Metab 33:79-88. doi: 10.1515/jpem-2019-0234.

Recent Chapter in Book:

• Tripathi, MK, Sharma, S, Singh, TP, Ethayathulla, AS, Kaur P (2021) Computational Intelligence in Drug Repurposing for COVID-19 in 'Computational Intelligence Methods in COVID-19: Surveillance, Prevention, Prediction and Diagnosis" in the series Studies in Computational Intelligence', Pg 273 - 294 Ed. Khalid Raza Springer Singapore

• Kumar A, Sehgal R, Roy TS. A morphometric analysis and study of variations of foramina in the floor of the middle cranial fossa. J Anat Soc India 2016; 65(2): 143-147.
• Deshmukh VR, Singh S, Sehgal R. Cysto-duodeno-colic ligament and its clinical relevance. Biomed J 2016; 39(6): 414-416.

• Gupta CL, Nag TC, Jha KA, Kathpalia P, Maurya M, Kumar P, Gupta S, Roy TS (2020) Changes in the inner retinal cells after intense and constant light exposure in Sprague-Dawley rats. Photochem Photobiol 96: 1061-1073.
• Nag TC, Kathpalia P, Wadhwa S (2020) Microtubule alterations may destabilize photoreceptor integrity: Age-related microtubule changes and pattern of expression of MAP-2, Tau and hyperphosphorylated Tau in aging human photoreceptor cells. Exp Eye Res 198:108153.
• Maurya M, Nag TC, Kumar P, Roy TS (2021) Expression patterns of iron regulatory proteins after intense light exposure in a cone-dominated retina. Mol Cell Biochem 476: 3483-3495.
• Nag TC (2021) Pathogenic mechanisms contributing to the vulnerability of aging human photoreceptor cells. Eye 35: 2917-2929.
• Nag TC, Gorla S, Kumari C, Roy TS (2021) Aging of the human choriocapillaris: Evidence that early pericyte damage can trigger endothelial changes. Exp Eye Res 212:108771.

• Arora P, Dhingra R, Bhatla N, Sharma A. VEGF and sFlt-1 polymorphisms in Preeclampsia. Placenta 2016; 45: 118–119
• Arora P, Kshetrapal P, Bhatla N, Rani N, Mochan S, Gupta SK, Saxena S, Dhingra R. Matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase- 2 mRNA levels in early onset preeclampsia. Placenta 2017; 51:131-132
• Gupta SK, Bhatla N, Rani N, Mochan S, Saxena S, Arora P, Dhingra R. Hydrogen sulphide producing enzymes are decreased in placentas from preeclampsia. Placenta. 2017; 51: 131.
• Mochan S, Bhatla N, Rani N, Gupta SK, Saxena S, Arora P, Dhingra R. SFLT-1 induces endoplasmic reticulum stress by activating perk pathway in bewo cells Placenta. 2017; 51: 131.

• Marik B, Bagga A , Sinha A  , Khandelwal P , Hari P , Sharma  A.  Genetic and clinical profile of patients with hypophosphatemic rickets. Eur J Med Gen 21 June 2022. https://doi.org/10.1016/j.ejmg.2022.104540.
• Vanathi M, Kishore A, Gupta Y, Setty PB, Sen S, Nag TC, Gupta R,  Sharma A, Tandon R. Recurrence in Reis Bücklers corneal dystrophy: Clinicopathological correlation. Indian J Ophthalmol Case Rep 2022; 2:371-5.
• Chakraborty S, Sharma A, Bagchi I, Pal S, Bhattacharyya C, Gupta V, Maitra A, Bhattacharjee S, Sharma A, Sihota R, Acharya M. A genomewide association study on individuals with occludable angles identifies potential risk loci for intraocular pressure. J Genet. 2021;100:69. PMID: 34608871
• Sarkar S, Singh R, Sharma A, Pandit MA, Gupta R, Singhal D, Jain R, Balhara YP. Association of Serotonergic Pathway Gene Polymorphisms With Behavioral Parameters in Patients With Opioid Dependence. Cureus. 2021 Nov 6;13(11):e19310. doi: 10.7759/cureus.19310. PMID: 34900485; PMCID: PMC8647861
• Gupta V, Somarajan BI, Kaur G, Gupta S, Singh R, Pradhan D, Singh H, Kaur P, Sharma A, Chawla B, Pahuja A, Ramachandran R, Sharma A. Exome sequencing identifies procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 mutations in primary congenital and juvenile glaucoma. Indian J Ophthalmol. 2021 Oct;69(10):2710-2716. doi: 10.4103/ijo.IJO_1750_21. PMID: 34571620; PMCID: PMC8597539.
• Gupta V, Somarajan BI, Gupta S, Walia GK, Singh A, Sofi R, Chaudhary RS, Sharma A. The mutational spectrum of Myocilin gene among familial versus sporadic cases of Juvenile onset open angle glaucoma. Eye (Lond). 2021;35(2):400-408.
• Grover T, Gupta R, Arora G, Bal CS, Ambekar A, Ray SB, Vaswani M, Sharma A. Dopamine transporter availability in alcohol and opioid dependent subjects – a 99mTc-TRODAT1SPECT imaging and genetic association study. Psychiatry Res Neuroimaging. 2020; 305:111187. doi: 10.1016/j.pscychresns.2020.111187. Online ahead of print.

Selected Publications/Patents(Last 5 years)

• Gupta A, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP. (2019). Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A. Int J Biol Macromol. S0141-8130(19) : 35145-1.
• Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S, Chauhan SS, Singh TP. (2018) A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. 644:72-80.
• Sharma, S., Kaushik, S., Sinha, M., Singh, A., Sikarwar, J., Chaudhary, A., Gupta, A., Kaur, P. & Singh, T.P. (2014). Structural and functional insights into Peptidyl-tRNA Hydrolase. Biochem. Biophys. Acta.1844: 1279-1288
• Structure and binding studies of proliferating cell nuclear antigen from Leishmania donovani. (2017) Yadav SP, Singh PK, Sharma P, Iqbal N, Kaur P, Sharma S, Singh TP. Biochim Biophys Acta Proteins Proteom. 1865:1395-1405.
• Singh PK, Sirohi HV, Iqbal N, Tiwari P, Kaur P, Sharma S, Singh TP. (2017) Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution. Biochim Biophys Acta Proteins Proteom. 1865:329-335.
• Rastogi, N., Singh. A., Pandey, S.N., Sinha, M., Bhushan, A., Kaur, P. & Singh, T.P. (2014). Structure if the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut. FEBS J. 281: 2871-2872.
• Kaushik, S., Singh, N., Yamini, S., Singh, A., Sinha, M., Arora, A., Kaur, P., Sharma, S. & Singh, T.P. (2013). The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii. PLoS One. 8, e67547.
• Kushwaha, G.S., Pandey, N., Sinha, M, Kaur, P., Sharma, S. & Singh, T.P. (2012) Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states.Biochim Biophys Acta. 1824 :679-691.
• Sharma, P., Dube, D., Sinha, M., Mishra, B., Dey, S., Mal, G., Pathak, K.M.L., Kar, P., Sharma, S. & Singh, T.P. (2011). Multi-ligand specificity of pathogen associated molecular-binding site in peptidoglycan recognition protein. J. Biol. Chem. 286 : 31723-31730
• Sharma, P., Dube, D., Singh, A., Mishra, B., Singh, N., Sinha, M., Dey, S., Kaur, P., Mitra, D.K., Sharma, S. & Singh, T.P. (2011). Structural basis of recognition of pathogen-associated molecular patterns and inhibition of pro-inflammatory cytokines by camel peptidoglycan recognition protein. J. Biol Chem. 286 : 16208-16217.
• Singh, A.K., Kumar, R.P., Pandey, N., Singh, N., Sinha, M., Bhushan, A.,Kaur, P., Sharma, S. & Singh, T.P. (2009). Mode of binding of the tuberculosis prodrug isoniazid to peroxidases: Crystal structure of bovine lactoperoxidase with isoniazid at 2.7A resolution. J. Biol. Chem. 285, 1569-1576
• Mir, R., Singh, N., Vikram, G., Kumar, R.P., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural basis of the prevention NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe)of bovine colostrums protein lactoferrin: Binding andstructural studies of the C-lobe complexes with indomethacin, diclofenac, aspirin and ibuprofen. Biophys. J. 97, 3178-3186
• Singh, A.K., Singh, N., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications : Crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid and benzylhydroxamic acid.J. Biol. Chem. 284, 20311-20318.
• Sheikh, I.A., Singh, A.K., Singh, N., Sinha, M., Singh, S.B., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural evidence of substrate specificity in mammalian peroxidases: Structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4A resolution. J. Biol. Chem. 284, 14849-14856.
• Singh, A.K., Singh, N., Sharma, S., Shin, K., Takase, M., Kaur, P., Srinivasan, A. & Singh, T.P. (2009). Inhibition of lactoperoxidase by its own catalytic product: Crystal structure of the hypothiocyanate-inhibited bovine lactoperoxidase at 2.3A resolution. Biophys. J. 96, 646-654.

• Bisht S, Faiq M, Tolahunase M, Dada R. Oxidative stress and male infertility. Nat Rev Urol. 2017 Aug;14(8):470-485. doi: 10.1038/nrurol.2017.69. Epub 2017 May 16. PMID: 28508879.
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