Faculty

Dr.
Sujata Mohanty

Affiliation

Professor

Department of

Stem Cell Facility

Contact

Email :

drmohantysujata@gmail.com

scfaiims@gmail.com

Phone :

011-26593085

9868398194

Professional Experience and Training relevant to the Project

Membership of the Technical Expert Groups and Consultancy

1	Member of Institute Committee for Stem Cell Research	National Institute of Immunology, New Delhi Institute of Liver & Billiary Sciences, New Delhi DBT Representative at Apollo Hospital Sri Ganga Ram Hospital, New Delhi V. P. Chest Institute, New Delhi National Brain Research Centre, Manesar THSTI, Faridabad IIT, Indore
2	Member: International Bodies	International Society for Cellular Therapy (ISCT) International Society for Stem Cell Research (ISSCR) Society of Biological Chemists (SBC) Indian Immunology Society Indian Society of Nanomedicine Indian Science Congress Association Stem Cell Research Foundation of India Cytometry Society of India
3	Member of Advisory Bodies	Core Committee for Stem Cell Donor Registry for Bone Marrow Transplant in India Stem Cell Donor Registry, Ministry of Science & Family Welfare, Govt. of India High Powered Committee by Ministry of Health and Family Welfare, Govt. of India Brainstorming meeting on Biofabrication & 3D Bioprinting Expert Group Committee - Limbal Stem Cell Transplantation - ICMR Centre for Induced Pluripotent Stem Cell Research and Application (CiRA) – For collaboration Investigating team of CDSCO - Dendritic Cell Vaccine Scandal Department of Biotechnology Task Force on Bioengineering DBT Expert Committee for Indo-Australian Career Boosting Gold Fellowships (IACBG-Fellowships)
4	Member- Research Grant Review Committee	Project Monitoring Committee (BIRAC), DBT Biotechnology Career Advancement and Reorientation Program for Women Scientists (BioCare), DBT Biotechnology Industry Research Assistance Council (BIRAC) Indian Council of Medical Research, New Delhi Department of Science and Technology, New Delhi Council of Scientific and Industrial Research, New Delhi Peer Review Committee - DRDO-Apollo Hospital, Hyderabad
5	Member- Journal Review Committee	Stem Cell Research Open Library (SCROL) Life Science Journal of Biosciences Biomedical Research Journal Insights in Stem Cells World Journal of Stem Cells CEINCIA Publishing Group Translational Surgery Molecular and Cellular Biochemistry
6	Member- Editorial Committee	Journal- Current Trends in Stem Cells and Regenerative Medicine (CTSR) Jacobs Journal of Bone Marrow and Stem Cell Research Scientific Reports, Nature Publishing House Stroke Research & Treatment

Publications

Published
- Research Papers: 99
- Abstracts: 88
Submitted: 15

Patents (filed): 02

Book Chapters:03

Mohanty S (2016), Cellular Therapy for Ocular Diseases (pp467-478). ThirumurthyVelpandian, Pharmacology of Ocular Therapeutics- Springer Nature, New York. DOI 10.1007/978-3-319-25498-2
Mohanty S (2016), Regenerative Medicine. D. Prabhakaran, Tandon’s Textbook of Cardiology.(Under review)
Mohanty S (2016), Clinical trials of cardiac regeneration using adult stem cells: Current and future prospects, Regenerative Medicine: Laboratory to Clinic- Springer Nature (Under review)

Honors/Awards

University Grant Commission (UGC) fellowship during Ph.D (1991).
Junior Investigator Prize for best paper (1997).
Post-Doctoral fellowship from Mount Sinai hospital, New York, USA (1998).
Award from International Society for Stem Cell Research, USA (three times).
AIIMS Excellence Award in recognition of notable published research work. (2012, 2014 & 2015).
Bharat Jyoti Award from India International Friendship Society (2013).
Third prize for poster presentation in 15th INDO-US Flow Cytometry Workshop on “STEM CELLS’’ , 2014.
ICMR International Fellowship (2014-2015) for training at Kyoto Prefectural University of Medicine, Kyoto, Japan, in Stem Cells and Scaffolds.
Best paper award for poster presentation in 43rd Annual Conference of the Indian Immunology Society (2017).

2017

Evaluating the osteogenic potential of CHT/HAP/PCL biocomposites in bone tissue engineering: An in vivo study. Krishan Gopal Jain, Manisha Singh, Anupama Kakkar, Rajesh Malhotra, Vineeta Batra, Alok Ray, Balram Airan, Mohanty S. International Journal Of Scientific Research (Accepted) https://www.worldwidejournals.com/international-journal-of-scientific-research(IJSR)//articles.php?val=MTA3NTE=&b1=673&k=169
Bone Marrow stem cell therapy partially ameliorates pathological consequences of liver in mice expressing mutant α1-antitrypsin. Prakash Baligar, Veena Kochat, Shailendra K. Arindkar, Zaffar Equbal, Snehashish Mukherjee, Swati Patel, Perumal Nagarajan, Mohanty S, Jeffrey H. Teckman, Asok Mukhopadhyay (2017 Hepatology. Volume 65, Issue 4, pages 1319–1335, April 2017)https://www.ncbi.nlm.nih.gov/pubmed/28056498
Hypoxia-mediated epigenetic regulation of stemness in brain tumor cells. Pankaj Prasad, Shivani Mittal, Mohanty S, Tapasya Srivastava. Stem Cells, 2017 STEM2621 (Accepted). https://www.ncbi.nlm.nih.gov/pubmed/28376560
Differential Reduction of Reactive Oxygen Species by Human Tissue-Specific Mesenchymal Stem Cells from Different Donors Under Oxidative Stress. Paliwal Swati, Kakkar Anupama, Rinkey Sharma, Airan Balram, Mohanty S (2017) Journal of BioSciences -D-16-00538R1 (Accepted)

2016

Fabrication of transparent quaternized PVA/silver nanocomposite hydrogel and its evaluation as an antimicrobial patch for wound care systems. Bhowmick, S., Mohanty, S. & Koul, V. (2016). J Mater Sci: Mater Med (2016) 27: 160. doi:10.1007/s10856-016-5772-8.https://www.ncbi.nlm.nih.gov/pubmed/27638099
Effect of Hypoxia on Stemness and Differentiation of Dental Pulp Derived Stem Cells.Anupama Kakkar, Puneet Sharma, Manimuthu Mani Sankar, OP Kharbanda, Mohanty S* IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) olume 15, Issue 8 Ver. VII (August. 2016), PP 102-111, http://www.iosrjournals.org/iosr-jdms/papers/Vol15-Issue%208/Version-7/T150807102111.pdf
Can Mesenchymal Stem Cell be used as an Additive Therapeutic Procedure for Fracture Healing in Facial Injuries??Ruchi Pathak Kaul, Sushma Sagar, Mohanty S, Subodh Kumar (2016). Journal of Dental and Oral Health Volume 2 • Issue 4 • e106
Feeder and bFGF free culture of human embryonic stem cells: Role of conditioned media from immortalized human feedersPooja Teotia, Mohanty S*, Shilpa Sharma, Balram Airan;c Manuscript ID: IJMR_152015-0472(424-15) (Accepted). https://www.ncbi.nlm.nih.gov/pubmed/28474621
Evaluation of sterilization of contaminated donor corneas by Gamma irradiation. Himi Tripathi, Pratik Kumar, Deepika Gupta, Rebika Dhiman, SeemaSen, SeemaKashyap, Tapas Nag, GeetaSatpathi, Mohanty S*, RadhikaTandon. IOVS Manuscript ID: IOVS-15-18223 (Accepted)
Hair and Skin derived Progenitor Cells: In Search of a Candidate Cell for Regenerative Medicine Anil Kumar, Mohanty S*, Sushmita Bose Nandy, Somesh Gupta, Binod K Khaitan, Shilpa Sharma, BalramBhargava, BalramAiran .Indian J Med Res 2016 Feb;143(2):175-83.https://www.ncbi.nlm.nih.gov/pubmed/27121515
Report: Stem cell applications in neurological practice, an expert group consensusappraisal. Devi M G, Sharma A, Mohanty S, Jain N, Verma K, Padma M V, Pal P, Chabbra H S, Khadilkar S, Prabhakar S, Singh G. Ann Indian Acad Neurol 016;19:367-73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980961/
Evaluation of circulating haematopoietic progenitor cells in patients with Trauma Haemorrhagic shock and its correlation with outcomes. umar M, Bhoi S, Subramanian A, Kamal VK, Mohanty S, Rao D, Galwankar S. Int J Crit Illn In jSci 2016;6:56-60. https://www.ncbi.nlm.nih.gov/pubmed/27308251
Long Term Preservation of Donor Corneas in Glycerol for Keratoplasty: Exploring New Protocols.HimiTripathi^,,ManzoorUl Mehdi, Deepika Gupta, SeemaSen, SeemaKashyap,Tapas Chandra Nag, ManishaPurwar, ManjeetJassal, Ashwini K Agrawal, MohantyS*^,Radhika Tandon. Br J Ophthalmol 2016 Feb;100(2):284-90. http://bjo.bmj.com/content/early/2015/10/26/bjophthalmol-2015-306944

2015

Stem Cells of the Hair Follicular Tissue: Application in Cell Based Therapy for Vitiligo. Kumar A, Mohanty S, Gupta S, Paulkhurana SM (2015) Hair Ther Transplant :132. doi:10.4172/2167-0951.1000132. https://www.omicsgroup.org/journals/stem-cells-of-the-hair-follicular-tissue-application-in-cell-based-therapyfor-vitiligo-2167-0951-1000132.php?aid=47699
Culture & differentiation of Mesenchymal Stem Cell into osteoblast on degradable biomedical composite scaffold: In vitro study. ain KG, Mohanty S, Ray AR, Malhotra R, Airan B. Indian J Med Res 2015 Dec;142(6):747-58. https://www.ncbi.nlm.nih.gov/pubmed/26831424
“An invention of thermo-responsive polymer surface, yielding cell sheet based regenerative therapies in cardiology and ophthalmology” Sawa Y , Cherian KM , Mohanty S , Ganesh JS , Abraham S Journal of Stem cells and Regenerative medicine 2015 JSRM Code: 011020700010. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728217/
Long Term Outcomes of Cultivated Limbal Epithelial Transplantation: Evaluation and Comparison of Results in Children and Adults Anita Ganger, M. Vanathi, Mohanty S , Radhika Tandon;; BioMed Research International vol. 2015, Article ID 480983, 6 pages, 2015. doi:10.1155/2015/480983. https://www.hindawi.com/journals/bmri/2015/480983/
Efficacy of stem cell in improvement of left ventricular function in acute myocardial infarction - mi3 trial; elu Nair, Hemant Madan, Sunil Sofat, ProsenjitGanguli, M.J. Jacob, Rajat Datta, Prashant Bharadwaj, R.S. Sarkar, A.J. Pandit, Soniya Nityanand, Pravin K. Goel, Naveen Garg, Sanjay Gambhir, Paul V. George ,Sunil Chandy, Vikram Mathews, Oomen K. George, K.K. Talwar, Ajay Bahl, Neelam Marwah, Anish Bhatacharya, Balram Bhargava, Balram Airan, Mohanty S, Chetan D. Patel, Alka Sharma,Shinjini Bhatnagar, A. Mondal, Jacob Jose, A. Srivastava; IJMR 2015 ;142(2):165-74. https://www.ncbi.nlm.nih.gov/pubmed/26354213
Enhanced reprogramming efficiency and kinetics of induced pluripotent stem cells derived from human duchenne muscular dystrophy; PoojaTeotia, Mohanty S*, Madhulika Kabr, Sheffali Gulati, Balram Airan; PLOS Currents: Muscular Dystrophy; ersion 1. PLoSCurr. 2015 September 3; 7. https://www.ncbi.nlm.nih.gov/pubmed/26579330
Role of Human Cardiac biopsy derived Conditioned Media in modulating Bone Marrow derived Mesenchymal Stem Cells towards Cardiomyocyte like Cells; Anupama Kakkar, Mohanty S*, BalramBhargava, BalramAiran^;July,2015; Journal of Practice of Cardiovascular Sciences; 015; 1(2):150-155. http://www.j-pcs.org/article.asp?issn=2395-5414;year=2015;volume=1;issue=2;spage=150;epage=155;aulast=Kakkar
Evaluation of serum granulocyte colony stimulating factors in patients admitted with Trauma Haemorrhagic shock and their correlation with immediate outcome.Manoj Kumar, Sanjeev Bhoi, S. Arul Selvi, Vineet Sharma, Mohanty S, D. N. Rao Int. J. Adv. Res. Biol.Sci 2(7): (2015): 107–114. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901827/
Interleukin (IL)-8 is an early predictor of mortality following trauma hemorrhagic shock ; Manoj Kumar, D.N Rao, Mohanty S, Arul Selvi S, SanjeevBhoi; Int. J. Adv. Res. Biol.Sci 2(7): (2015): 12–20. https://www.omicsonline.org/proceedings/interleukin-il8-early-predictor-of-mortality-following-trauma-hemorrhagic-shock-29282.html
Strategies for faster detachment of corneal cell sheet using micropatterned thermo-responsive matrices.Sharda Nara, Shibu Chameettachal, Swati Midha, Himi Singh, Radhika Tandon, Mohanty S, Sourabh Ghosh J. Mater. Chem. B 015,3, 4155-4169. http://pubs.rsc.org/en/Content/ArticleLanding/2015/TB/c5tb00350d#!divAbstract

2014

Detection of homing-in of stem cells labeled with technetium-99m hexamethylpropyleneamineoxime in infarcted myocardium after intracoronary injection. Patel CD, Agarwal S, Seth S, Mohanty S*, Aggarwal H, Gupta N. Indian J Nucl Med 2014 Oct;29(4):276-7. doi: 10.4103/0972-3919.14264. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228599/
Fibroblast Growth Factor-2 alone as an efficient inducer for differentiation of human bone marrow mesenchymal stem cells into dopaminergic neurons.Sushmita Bose, Mohanty S*, Manisha Singh, MadhuriBehari, BalramAiran Journal of Biomedical Science nbsp;2014, 21:83 doi:10.1186/s12929-014-0083-1 https://www.ncbi.nlm.nih.gov/pubmed/25248378
Intravenous autologous bone marrow mononuclear cell therapy for ischemic stroke: A multi-centric, randomized trial. Kameshwar Prasad, Alka Sharma, Ajay Garg, Mohanty S, Shinjini Bhatnagar, Sharat Johri, KK Singh, Velu Nair, Ravi Sarkar, Sankar Gorthi, Kaukab Hassan, Sudesh Prabhakar, Neelam Marwaha, Niranjan Khandelwal, Usha Misra, Jayantee Kalita, and Soniya Nityanand. Stroke 2014/007028D-AR1. https://www.ncbi.nlm.nih.gov/pubmed/25378424
Autologous stem cell transplantation in refractory Asherman's syndrome: A novel cell based therapy. Neeta Singh, MohantyS*, Tulika Seth, Meenakshi Shankar, Sruthi Bhaskaran, Sona Dharmendra. J Hum Reprod Sci 2014 Apr-Jun; 7(2): 93–98. https://www.ncbi.nlm.nih.gov/pubmed/25191021
Stem cells in Neurological Diseases: Indian perspective. Ashu Bhasin, Padma Srivastava MV, Rohit Bhatia, Senthil Kumaran, Mohanty S.J Stem Cell Res Ther 2014, 4:3 (http://dx.doi.org/10.4172/2157-7633.1000175). https://www.omicsonline.org/open-access/review-stem-cells-in-neurological-diseases-indian-perspective-2157-7633.1000175.php?aid=23627
Effect of stem cells on renal recovery in rat model of partial unilateral upper ureteric obstruction. N. Sugandhi, M. Srinivas, S. Agarwala, D. K. Gupta, S. Sharma, A. Sinha, A. Dinda, S. Mohanty Pediatric surgery International, 2014. 30:233–238. https://www.ncbi.nlm.nih.gov/pubmed/24370792
Surface-Modified Electrospun Poly (e-Caprolactone) Scaffold With Improved Optical Transparency and Bioactivity for Damaged Ocular Surface Reconstruction.Shweta Sharma, Deepika Gupta ,Mohanty S, ManjeetJassal, Ashwini K. Agrawal , RadhikaTandon. Invest Ophthalmol Vis Sci. 2014; 55:899–907. DOI:10.1167/ iovs.13-12727. https://www.ncbi.nlm.nih.gov/pubmed/24425860
5-Florouracil-loaded poly(lactic acid)-poly(caprolactone) hybrid scaffold: potential chemotherapeutic implant. Gupta KK, Pal N, Mishra PK, Srivastava P, Mohanty S, Maiti P. .J Biomed Mater Res A. 014 Aug;102(8):2600-12. https://www.ncbi.nlm.nih.gov/pubmed/24038786

2013

Propitious role of Bone marrow-derived mononuclear cells in an Experimental Bile Duct Ligation model - Potential clinical implications in obstructive cholangiopathy. Shilpa Sharma, Mohanty S*, Prasenjit Das, Sidhartha Dutta Gupta, Lalit Kumar, evendra Gupta.. Pediatric surgery International, 013 Jun;29(6):623-32. https://www.ncbi.nlm.nih.gov/pubmed/23604400
Depletion of CD200⁺bulge stem cells in premature human gray hair follicles. Mohanty S*, Anil Kumar, Somesh Gupta. J Cutan Aesthet Surg 2013 Apr-Jun; 6(2): 90–92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764768/
Stem Cell Niche is Partially Lost during Follicular Plucking: A Preliminary Pilot Study.Kumar A, Gupta S, Mohanty S, Bhargava B, Airan B. Int J Trichology 2013 Apr;5(2):97-100. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877484/
Extracted hair follicle outer root sheath cell suspension for pigment cell restoration in vitiligo.Kumar A, Mohanty S, Sahni K, Kumar R, Gupta SJ Cutan Aesthet Surg 2013 Apr;6 (2):121-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764761/
Limbal Epithelial stem cells in Corneal Regeneration Shweta Sharma, M Vanathi, Mohanty S, RadhikaTondon.Delhi Journal of Opthalomology;2013; 24(1:43-50).http://www.djo.org.in/articles/24/1/Limbal-Epithelial-Stem-Cells-in-Corneal-Regeneration.html
TGF-beta1 contribues to cardiomyogenic like differentiation of human bone marrow Mesenchymal Stem Cells. Mohanty S, Sushmita Bose, KrishanGopal Jain, Balram Bhargava, Balram Airan.International Journal of Cardiology 2013 Feb 10;163(1):93-9. https://www.ncbi.nlm.nih.gov/pubmed/21903280

Dr.
Karthikeyan P

MD, PhD

Affiliation

Department of

Biochemistry

Contact

Email :

karthikeyan_p@aiims.edu

karthi.dr@gmail.com

Public profiles:

Orcid | Google Scholar | Research Gate | YouTube | Goodreads

Academic Qualifications:

Sr. No.	Degree	Year	Subject	University/Institution
1.	MBBS	2010	All Subjects	Kanyakumari Government Medical College
2.	MD	2015	Biochemistry	Maulana Azad Medical College
3.	DNB	2016	Biochemistry	National Board of Examinations
4.	PhD	2022	Biochemistry	AIIMS, New Delhi

Work Experience:

Sr. No.	Positions held	Name of the Institute	Period
1	Junior Resident	Maulana Azad Medical College	2012 - 2015
2	Senior Resident	AIIMS, New Delhi	2015 - 2018
3	Research Associate II	AIIMS, New Delhi	2019 - 2022
4	Assistant Professor	Maulana Azad Medical College	May 2022 – Jan 2023

Book and Book Chapters:

Biochemistry For Undergraduates, First Edition, CBS Publishers (ISBN – 9789388725972)
Eleven chapters in Springer - Nature publication, Encyclopaedia of Animal Cognition and Behaviour

Memberships:

Member of National Academy of Medical Sciences, India (MNAMS)
Life member of Association of Medical Biochemists of India (AMBI)
Life Member of Clinical Biochemists of India (ACBI)
Life Member of Indian Immunology Society

Positions Available in the Lab:

If you are interested in working on similar projects as ours or have a unique idea in any field that you wish to pursue, please send an email to karthikeyan_p[at]aiims[dot]edu.People with independent fellowships are welcomed. Let's explore opportunities for collaboration and growth together.

Professional Recognition/Award/ Prize/Certificate:

Sr. No	Name of Award	Awarding Agency	Year
1	FIRST PRIZE in Biochemistry Quiz Competition	Association of Medical Biochemists of India	2014
2	Certificate for BEST JOURNAL CLUB PRESENTATION	Dept. of Biochemistry, AIIMS, Delhi	2017
3	Acknowledgement in Harper illustrated Biochemistry, 31st edition for suggestions and corrections	Victor W. Rodwell (chief editor)	2018
4	Research Associate Fellowship	Indian Council of Medical Research	2019
5	Certificate for Quiz Master	Indian Immunology Society	2020, 2021, 2022

Research focus

Leukemia Biology, Bioinformatics, Medical Education

Publications (PubMed indexed only):

Sr. No	Author(s)	Title	Name of Journal	Volume	Page	Year
1	Pethusamy K, Seethy A, Dhar R, Karmakar A, Chaudhary S, Bakhshi S, P JK, Chopra A et al.	Loss of TET2 with reduced genomic 5-hmC is associated with adverse-risk AML	Leukemia & lymphoma	63(14)	3426-3432	2022
2	Sahoo OS, Pethusamy K, Srivastava TP, Talukdar J et al.	The metabolic addiction of cancer stem cells.	Frontiers in oncology	12:955892.	eCollection	2022
3	Chattopadhyay I, Dhar R, Pethusamy K, Seethy A et al.	Exploring the Role of Gut Microbiome in Colon Cancer	Applied Biochemistry and Biotechnology	193(6)	1780-1799	2021
4	Seethy A, Pethusamy K, Chattopadhyay I, Sah R et al.	TETology: Epigenetic Mastermind in Action	Applied Biochemistry and Biotechnology	193(6)	1701-1726	2021
5	Dhar R, Seethy A, Singh S, Pethusamy K, Srivastava T et al.	Cancer immunotherapy: Recent advances and challenges.	Journal of Cancer Research and Therapeutics	17(4)	834-844	2021
6	Dhar R, Singh S, Mukherjee I, Pethusamy K, Purkayastha K et al.	EMTiness in pseudo-malignant behavior of trophoblasts during embryo implantation.	Frontiers in Bioscience-Landmark	26(4)	717-743	2021
7	Seethy AA, Singh S, Mukherjee I, Pethusamy K et al.	Potential SARS-CoV-2 interactions with proteins involved in trophoblast functions - An in-silico study.	Placenta	103	141-151	2021
8	Chakraborty M, Singh P, Dsouza JMP, Pethusamy K et al.	Fasting and postprandial lipid parameters: A comparative evaluation of cardiovascular risk assessment in prediabetes and diabetes.	J Family Med Prim Care	28;9(1)	287-292	2020
9	Dhar R, Pethusamy K, Singh S, Mukherjee I et al.	Draft genome of Ompok bimaculatus (Pabda fish).	BMC Research Notes	26;12(1)	825	2019
10	Dhar R, Seethy A, Pethusamy K, Singh S et al.	De novo assembly of the Indian blue peacock (Pavo cristatus) genome using Oxford Nanopore technology and Illumina sequencing.	Gigascience	1;8(5)	giz038	2019

Dr.
Siddhartha Kundu

MD, PhD

Affiliation

Associate Professor

Department of

Biochemistry

Contact

Email :

siddhartha_kundu@aiims.edu

siddhartha_kundu@yahoo.co.in

Phone :

+91-11-26546514

Areas of Interest

Mathematical analyses of biochemical reactions & metabolic networks Mathematical modelling and simulations of complex biochemical systems Algorithms for molecular biology

Servers/Software developed

Hyperlink	Description
http://doi.org//10.1142/S0219720022500184 https://cran.r-project.org/package=TemporalGSSA	[Siddhartha_kundu_img1.png]
http://doi.org//10.3389/fmolb.2023.1206502 https://cran.r-project.org/package=ReDirection	[Siddhartha_kundu_img2.png]
http://doi.org//10.1177/11779322211045878 http://178.63.18.214/ProTG4.html	[Siddhartha_kundu_img2.png]
http://doi.org/10.1186/s13104-021-05477-z http://178.63.18.214/Fe2OG.html	[Siddhartha_kundu_img2.png]

Educational qualifications

Degree	Subject	University/Institution	Year
PhD	Computational Biology & Bioinformatics	School of Computational and Integrative Sciences (SCIS), Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067	2014-2018
MD	Biochemistry	All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi 110029	1999-2001
MBBS	Pre-&Para-/Medical/ Surgical subjects	University College of Medical Sciences (UCMS), Dilshad Garden, New Delhi 110095	1992-1996

Memberships

1.	Society for Mathematical Biology (SMB): Life member (ID:36503496)
2.	European Society for Mathematical and Theoretical Biology (ESMTB) : Life member ID: 50143836
3.	Elected member Sigma Xi society ( Scientific Research Honors Society)

Positions held

Position	Subject/Work	University/Institution	Year
Associate Professor Assistant Professor	Biochemistry	All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi 110029	2023-2019-2023
Associate Professor	Biochemistry	Army College of Medical Sciences (ACMS), Brar Square, Delhi Cantt., New Delhi – 110010 Dr. Baba SahebAmbedkar Medical College and Hospital (BSAMCH), Govt. of NCT of Delhi, Rohini, Delhi 110085	2015-2018 2018-2019
Assistant Professor	Biochemistry	Army College of Medical Sciences (ACMS), Brar Square, Delhi Cantt.,New Delhi – 110010	2009-2014
Scientist ‘D’ (Medical)	Program Officer	Indian Council of Medical Research (ICMR), V. RamalingaswamiBhawan, Ansari Nagar, New Delhi 110029	07-10/2019
Senior Level Consultant	Program Director	Information Technology Research Academy (ITRA), Digital India Corporation (formerly Media Lab Asia), Ministry of Electronics and Information Technology, C-DOT campus, New Delhi 110030	2016-2017
Research Consultant	Computational Biology	India Research Labs (IRL) IBM	2002-2003
Research Associate/Fellow/Scientist	PostDoctoral work	International Center for Genetic Engineering and Biotechnology (ICGEB) National Institute of Immunology (NII) ICMR-National Institute of Pathology (NIOP) Indian Institute of Technology Delhi (IITD)	05-10/2014 2005-2008 2003-2004 01-05/2002

Award/recognition:

AIIMS excellence research award (Certificate of commendation)

1.	2022	Kundu S^#. TemporalGSSA: a numerically robust R-wrapper to facilitate computation of a metabolite-specific and simulation time-dependent trajectory from stochastic simulation algorithm (SSA)-generated datasets. Jour Bioinf. Comp. Biol.* 2022, 20(4):2250018. PMID: 35941839 JBCB2022 (Additional Material).
2.	2021	Kundu S^#. Mathematical modeling and stochastic simulations suggest that low-affinity peptides can bisect MHC1-mediated export of high-affinity peptides into “early”- and “late”-phases. Heliyon*. 2021, 7(7):e07466. PMID: 34286133 [HYON2021] (Additional Material).

Research publications (complete citations)

2024	*(Preprint) Kundu S#. Construction, analysis and assessment of relevance of an algebraic model for a class of biochemical networks. (https://doi.org/10.1101/2024.03.07.583960) Kundu S#.* A mathematically rigorous algorithm to define, compute and assess relevance of the probable dissociation constants in characterizing a biochemical network. Scientific Reports2024, 14. PMID: 38347039 [SCIR2024] (Additional Material).
2023	Kundu S#. ReDirection: an R-package to compute the probability dissociation constant for every reaction of a user-defined biochemical network. Front Mol Biosci.* 2023, 10. PMID: 37942290 [FMBI2023]. (Additional Material)
2022	Kundu S^#. Modeling ligand-macromolecular interactions as eigenvalue-based transition-state dissociation constants may offer insights into biochemical function of the resulting complexes. Math Biosci Eng.* 2022, 19(12): 13252-275. [MBE2022] (Additional Material). Kundu S^#. TemporalGSSA: a numerically robust R-wrapper to facilitate computation of a metabolite-specific and simulation time-dependent trajectory from stochastic simulation algorithm (SSA)-generated datasets. Jour Bioinf. Comp. Biol.* 2022, 20(4):2250018. PMID: 35941839JBCB2022 (Additional Material).

2021	*Kundu S#.** ProTG4: A Web Server to Approximate the Sequence of a Generic Protein From an in Silico Library of Translatable G-Quadruplex (TG4)-Mapped Peptides. Bioinform Biol Insights. 2021, Sep 28;15:11779322211045878. PMID: 34602814. [BBI2021](Additional Material). *Kundu S#.** Mathematical modeling and stochastic simulations suggest that low-affinity peptides can bisect MHC1-mediated export of high-affinity peptides into “early”- and “late”-phases. Heliyon. 2021, 7(7):e07466. PMID: 34286133 [HYON2021](Additional Material). *Kundu S#.** Fe(2)OG: An integrated HMM profile-based web server to predict and analyze putative non-haemiron(II)- and 2-oxoglutarate- dependent dioxygenase function in protein sequences. BMC Res Notes. 2021, 14(1):80. PMID: 33648553. [BMRN2021] (Additional Material).
2020	*Kundu S#.** Mathematical model of a short translatable G-quadruplex and an assessment of its relevance to misfolding-induced proteostasis. Math Biosci Eng. 2020, 17(3): 2470-2493. PMID: 32233549. [MBE2020] (Additional Material).
2019	*Kundu S#.** Insights into the mechanism(s) of digestion of crystalline cellulose by plant class C GH9 endoglucanases. J Mol Model. 2019 Jul 23;25(8):240. PMID: 31338614 [JMM-2019] (Additional Material).
2018	*Kundu S#.** Mathematical basis of predicting dominant function in protein sequences by a generic HMM-ANN algorithm. Acta Biotheor. 2018 Jun;66(2):135-148. PMID: 29700659,32385619 [ACBI2018] (Additional Material). *Kundu S, Sharma R.* Origin, evolution, and divergence of plant class C GH9 endoglucanases. BMC Evol. Biol. 2018 May 30;18(1):79. PMID: 29848310 [BMEB2018] (Additional Material).
2017	*Kundu S#.** Mathematical basis of improved protein subfamily classification by a HMM-based sequence filter. Math Biosci. 2017 Nov;293:75-80. doi:10.1016/j.mbs.2017.09.001. Epub 2017 Sep 13. PubMed PMID: 28916136. (Additional Material).
2016	*Kundu S, Sharma R.* In silico Identification and Taxonomic Distribution of Plant Class C GH9 Endoglucanases. Front Plant Sci. 2016 Aug 12;7:1185. PMID: 27570528 [FPS2016] (Additional Material). *Kundu S#.** Stochastic modelling suggests that an elevated superoxide anion-hydrogen peroxide ratio can drive extravascular phagocyte transmigration by lamellipodium formation. J Theor Biol. 2016 Oct 21;407:143-54. PMID: 27380944. (Additional Material).
2015	*Kundu S#.** Co-operative intermolecular kinetics of 2-oxoglutarate dependent dioxygenases may be essential for system-level regulation of plant cell physiology. Front Plant Sci. 2015 Jul 15;6:489. PMID: 26236316 [FPS2015a] (Additional Material). *Kundu S#.** Unity in diversity, a systems approach to regulating plant cell physiology by 2-oxoglutarate-dependent dioxygenases. Front Plant Sci. 2015 Mar 11;6:98. PMID: 25814993 [FPS2015b] (Additional Material).
2012	*Kundu S#.** Distribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases. BMC Res Notes. 2012 Aug 4;5:410. PMID: 22862831 [BMRN2012] (Additional Material).
2011	*Kundu S, Subodh S.** Gradient sensing in vectorial chemotaxis – a novel role for Reactive Oxygen Species. International Journal of Trends in Medicine. 2011 1; 54-59. [IJTM2011]
2002	Singh N, Khanna N, Sharma H, Kundu S, Azmi S. Insights into the molecular mechanism of apoptosis induced by TNF-alpha in mouse epidermal JB6-derived RT-101cells. Biochem Biophys Res Commun. 2002 Jul 5;295(1):24-30. PMID:12083761. [BBRC2002]
	*(#) Single author; ()Corresponding author**

Public profiles:

Orcid || Loop-Frontiers || Exaly || ResearchGate || GoogleScholar ||

Dr.
Rakhee Yadav

Affiliation

Additional Professor

Department of

Biochemistry

Contact

Email :

rakheeyadav79@gmail.com

rakheeyadav@aiims.edu

Academic Details

Degree	University/ Institution	Year of Passing
MBBS	Pt BD Sharma PGIMS, MD University, Rohtak (Haryana)	2002
MD (Biochemistry)	Pt BD Sharma PGIMS, Pt BD Sharma UHS, Rohtak (Haryana)	2011

Positions held (starting from the most recent):

Position	Department	University/ Institution	Period
Associate Professor	Biochemistry	AIIMS Delhi	2020 onwards
Assistant Professor	Biochemistry	AIIMS Delhi	2016-2020
Assistant Professor	Biochemistry	SGT Medical College & Hospital, Gurgaon (Haryana)	2014-2016
Senior Resident	Biochemistry	VMMC & Safdarjung Hospital Delhi	2011-2014

Research Focus of the Lab/ Key Areas: Adipocyte Biology, Insulin Resistance, Obesity & metabolic syndrome

Projects & Funding: ICMR Extramural and AIIMS Intramural Grants

List of Lab members:

1. Mr Blessed Raj (PhD Scholar):

Mr Blessed Raj has done MSc in Medical Biochemistry from JIPMER Puducherry and got registered as PhD scholar at AIIMS in Nov 2020. His proposed work is to elucidate the role of ECM-Adipocyte communication in obesity induced adipose tissue dysfunctions

2. Dr Astha Sachan (Senior Resident):

Has done MD Thesis under my supervision titled, “Study of ECM Remodeling in adipose tissue dysfunctions in obesity” and presently working in ongoing lab projects.

She has won Mrs. Dwarka Prasad Trust Travel Grant in 2019 to present her work at 15th Asia Pacific Federation for Clinical Biochemistry and Laboratory Medicine (APFCB) Congress; Jaipur in Nov 2019

Also won best oral paper award in AMBION 2020: National Postgraduate Update cum CME, Chandigarh, November, 2020 (Online Presentation)

3. Dr Kuntal Chakraborty (Final year MD Student):

Thesis title “A prospective study of changes in human Gut Microbiota (GM) and its association with insulin sensitivity in obese individuals undergoing Bariatric Surgery”

He has been awarded ICMR financial support for his MD thesis (Dec 2020)

4. Dr Prachi Priyadarshini (Final year MD student):

Thesis title “Study of the expression of vascular endothelial growth factor (VEGF-A) and its isoforms, in Obesity and their association with insulin sensitivity”

5.Dr Khushboo Sharma (Second year MD student):

Thesis titled “Assessment of Amphiregulin and CRISPLD1 as visceral adipose tissue derived modulators of cardiovascular health in obesity”

Research Focus of the Lab/ Key Areas: Adipocyte Biology, Insulin Resistance, Obesity & metabolic syndrome

Projects & Funding: ICMR Extramural and AIIMS Intramural Grants

List of Lab members:

1. Mr Blessed Raj (PhD Scholar):

2. Dr Astha Sachan (Senior Resident):

Has done MD Thesis under my supervision titled, “Study of ECM Remodeling in adipose tissue dysfunctions in obesity” and presently working in ongoing lab projects.

Also won best oral paper award in AMBION 2020: National Postgraduate Update cum CME, Chandigarh, November, 2020 (Online Presentation)

3. Dr Kuntal Chakraborty (Final year MD Student):

Thesis title “A prospective study of changes in human Gut Microbiota (GM) and its association with insulin sensitivity in obese individuals undergoing Bariatric Surgery”

He has been awarded ICMR financial support for his MD thesis (Dec 2020)

4. Dr Prachi Priyadarshini (Final year MD student):

Thesis title “Study of the expression of vascular endothelial growth factor (VEGF-A) and its isoforms, in Obesity and their association with insulin sensitivity”

5.Dr Khushboo Sharma (Second year MD student):

Thesis titled “Assessment of Amphiregulin and CRISPLD1 as visceral adipose tissue derived modulators of cardiovascular health in obesity”

Dr.
Pramod Kumar Gautam

Affiliation

Additional Professor

Department of

Biochemistry

Contact

Email :

gautam@aiims.edu

pramodgautam_13@yahoo.com

Phone :

(O) 011-26594682; (Ext) 4682

Academic carrier

I am currently working as an additional professor in the Department of Biochemistry. My PhD and post-doctoral fellowship from Banaras Hindu University, Varanasi, India

Academic Activity

UG, PG teaching, and research

Administrative Positions/Activities

Member of the transport committee, AIIMS, New Delhi
Worked as a nodal officer for COVID control
Ph.D. course work in charge

Membership in the Society

Life member of the Indian Immunology Society, India
Life Member of Cancer Immunotherapy (CIMT), Germany
Indian Academy of Biomedical Sciences (IABS)
The Indian Association of Cancer Research (IACR)
Association of Clinical Biochemistry (ACBI)

Reviewer and Editorial Board Membership

The International Journal of Gastrointestinal Cancer
Journal of Nano particle research (2016 onward)
Journal of Leukemia Research (2016 onward)
BMC Cancer

Research Work: - Laboratory of Immunology and Cancer Immunotherapy

The immune system can be likened to a sophisticated army, equipped with various tools and mechanisms to protect the body from infections and cancers. However, during tumor development, cancer cells release substances that suppress the immune system, allowing the tumor to grow and spread. To combat this, researchers are focusing on developing immunotherapies that enhance the body's natural defenses against cancer. These immunotherapies target specific pathways involved in tumor growth, angiogenesis, and immune suppression. By discovering and studying the effects of natural compounds and plant extracts, scientists hope to develop safe and effective treatments for cancer that can be used in combination with existing therapies. The goal is to improve cancer management, early detection, and targeted drug delivery to prevent the progression of the disease. Our research lab utilizes advanced molecular & immunological techniques.

Extramural and Intramural Project:-

Elucidating the targeted, therapeutic role of docetaxel-loaded-HSP70 peptide complex in PDX Mouse Models. (PI, Ongoing, ICMR)
Role of M1 macrophage on DNA methylation and PI3K-AKT Signaling Pathway analysis in tumor-associated mesenchymal stem cells in Breast cancer.(PI, Ongoing, AIIMS)
Development of anti-proliferative agent form boerhaabia diffusa and citrullus colocynthis plant extract in human bladder cancer. (PI, Ongoing, AIIMS)
Role of Macrophage in the regulation of Bone and Blood forming stem cell and progenitor cells migration and development. (PI, Completed, DBT)
Evaluation of tumor-derived exosomes in blood during pre and post treatment of pancreatic cancer patients(PI, Completed, AIIMS)
Development of targeted drug delivery using liposomes/nanoparticles on cancer stem cell using herbal plant extract and hsp70- tumor antigen and to evaluate its anti-tumor function. (PI,SERB, Completed)
To emphasis the role of macrophage phenotype on mesenchymal stem cell in breast cancer. (Completed, AIIMS)
To study the role of β-defensin on stem cells, cancer stem cells remodelling and its associated microenvironments(AIIMS, Completed)

Group members:-

PhD thesis: completed-2; ongoing-1
MD Thesis: Completed-1; ongoing-1
Post Doc Fellow-1,
Research Scientist: 1 (an ICMRfunded project)
TARE, SERB, New Delhi—Dr. Qulsum Akhtar.
Project Staff: 2

Current lab members: Miss Anita (CSIR-JRF); Rupinder Kaur (CSIR-SRF, NET), Dr. Sreekar; Dr. Neha Singh; Dr. Soni Kumari (Research Scientist-II); Ankit Kumar; and Bharta Sinha (DEO, AIIMS, New Delhi).

Miss Anita

Anita submitted her thesis in the year 2024. Her title of thesis is to elucidate the immunomodulatory and anti-tumor role of m1 macrophage on bone marrow derived mesenchymal stem cells: implications in breast cancer. Anita has been qualified CSIR-JRF and currently working as a research scientist in the Dept. of Pharmacology at AIIMS, New Delhi.

Rupinder Kaur

ORCID: 0000-0002-0158-8307

Rupinder Kaur, a 4th year Ph.D. student (2020-present) and CSIR-SRF (Direct) fellow, delves into the fascinating world of cancer-immunology. Her research focuses on unraveling the immunomodulatory effects of tumor-derived exosomes on Gamma-Delta T cells. By exploring this intricate interaction, she aims to uncover potential therapeutic strategies for cancer treatment. Rupinder's work primarily consists of the analysis of differential micro-RNA cargo in extracellular vesicles in peripheral blood of cancer patients. She is also working on elucidating the mysteries of the change in polarity of gamma delta T cells under the effect of tumor derived extracellular vesicles. She completed her Master in Biochemistry in 2019 from Punjab Agricultural University, Ludhiana.

Thesis Title: “To study the immunomodulatory effect of tumor derived exosomes in Gamma-Delta T cells.”

Ankit Kumar

Myself, Ankit Kumar and I have done my B.Sc. in Zoology (Hons) from St. Xavier College Ranchi in 2018–21. and currently I have joined as M.Sc student and am working on a thesis titled "Differentially expressed exosomal miRNA derived from Pancreatic Ductal AdenoCarcionoma (PDAC)".

Neha Singh

Qualification- PhD in Microbiology

ORCID-https://orcid.org/0000-0001-9802-0445

Current affiliation- Project Student, Department of Biochemistry, All India Institute of Medical Sciences

Project Title-Elucidating the targeted therapeutic role of docetaxel- loaded- HSP70 peptide complex in PDX mouse models.

Expertise- Expert in microbiology, medicinal plants, and cancer biology. Skilled in analyzing microbial interactions, identifying medicinal compounds in plants, and studying cancer cell signaling pathways. Proficient in microbiological techniques, plant extraction methods, and cancer cell culture assays. Experience in research, drug discovery, and contributing to advancements in medical science.

Soni Kumari (Research Scientist II)

PhD in Biochemistry

ORCID ID: 0000-0002-9743-3202

I am currently working as a Research Scientist II on an ICMR-funded project titled “Elucidating the Therapeutic Role of Docetaxel-Loaded HSP Peptide Complex in PDX Mouse Model.”

Dr. K. V. Sreekar ( MD student)

He has a strong interest in cancer and cancer immunology and is about to embark on research in breast cancer immunology. His focus will be on developing new methods to detect novel biomarkers that can aid in the early diagnosis of breast cancer. He has finished his M.B.B.S. from Dr. NTR university of health sciences, Andhra Pradesh.

Previous Student:-

Dr. Sonam Agarwal (ICMR- RA);Dr.. Khuswant Singh (CSIR-JRF); Dr. Kunal Kumar; Dr. Vijay Mohan (Post Doc Fellow); Pavit Singh (MBBS-STS student).

Sonam Agarwal:- complete her work on “Detection of prostate cancer biomarker using sensitive and rapid lateral flow device with diagnostic and prognostic significance” (ICMR-RA)
Khushwant Singh:- Submitted his thesis on Determining the immunomodulatory and antitumor function of hsp70 chemotherapeutic drug conjugates on cancer stem cells
Marilyn Masih:-Completed her thesis on “Comparative analysis between different stage Cancer patients to discover Novel Blood – based biomarkers for detection of early stage breast cancer- A pilot study”
Pavit Singh (MBBS-STS student) “To study the differential exosomal abundance in pancreatic cancer patients”

Publication Details

https://orcid.org/0000-0001-7580-8846

https://scholar.google.co.in/citations?user=PBcBKhwAAAAJ&hl=en

Dr.
Riyaz Ahmad Mir

Affiliation

Additional Professor

Department of

Biochemistry

Contact

Email :

riyaz978@gmail.com

riyazmir@aiims.edu

Phone :

(O) 011-26593706 (Ext) 3706

Employment record:

Additional Professor	Biochemistry, AIIMS, New Delhi	2023- present
Associate Professor	Biochemistry, AIIMS, New Delhi	2020-2022
Assistant Professor	Biochemistry, AIIMS, New Delhi	2016-2020

Research Experience:

Postdoc Fellow	University of Nebraska Medical Center, USA	2011-2016
PhD	Biochemistry, AIIMS, New Delhi	2005-2011

Reviewer and Editorial Board Member:

Frontiers in Oncology
GENE
Editorial board member Translational pathology and Laboratory medicine
Editorial board member Clinical pathology and research Journal

Research focus of the lab:

We are a dedicated team of researchers focused on understanding the role of the R2TP complex in malignancy. The R2TP complex is a co-chaperone of Hsp90, involved in the assembly and stabilization of various macromolecular complexes in the cell. The interactions and collaborative functions of the R2TP complex with its clients remain poorly understood and unexplored. Our research delves into the molecular associations of the complex whilst cancer progression and how it can potentially be targeted for therapeutic interventions.

Additionally, we explore the functions of tumour suppressors, crucial proteins that play a pivotal role in preventing the uncontrolled growth of cancer cells. Understanding how these proteins operate and how they can be manipulated is a key aspect of our work.

Furthermore, our lab is also interested in the effects of genetic manipulation in mammalian inner ear cells. This area of research is important for understanding hearing loss and other inner ear disorders, and it has implications for the development of potential treatments.

We are committed to advancing knowledge in these areas and contributing to the development of novel strategies for treatment. To learn more about our ongoing projects and recent discoveries, please email

Dr Riyaz Mir

L to R: Ayesha, Pankaj, Hema, Dr Riyaz, Dhiraj and Mahaiwon

Present Lab members:

Ms Mahaiwon Shadang, PhD student, SRF-CSIR

Mahaiwon is investigating the molecular associations and clinical significance of the R2TP complex in cervical cancer. She joined the lab in August 2017 and completed her M.Sc. Medical Biochemistry in AIIMS, New Delhi in 2019 with a thesis that analyses the expression of the R2TP complex in Diffuse Large B Cell Lymphoma. She qualified for the CSIR NET JRF in 2017.

Mr Dhiraj Kumar Singh, PhD Student, SRF-CSIR

Dhiraj started work at AIIMS as JRF in 2018 and enrolled as a PhD student in 2019. He studies the role of PIH1D1 (a subunit of the R2TP complex) in various phases of the cell cycle. He has completed his M.Sc. Bioinformatics from Jamia Millia Islamia University. He also qualified for the CSIR JRF in 2017 with AIR-63.

Mr Pankaj Keshari, SRF

Pankaj’s work studies the trans-differentiation of inner ear supporting cells. This will provide insight into the development and function of supporting cells, leading to a better understanding of the biological roles these cells play.

Hema Yadav, PhD student, JRF-DBT

Hema studies the role of the R2TP complex in the etiology of thyroid cancer. She completed her M.Sc. Medical Biochemistry in AIIMS, New Delhi in 2021. Her Master's thesis explored the role of B cells in a spectrum of Tuberculosis. She has qualified CSIR JRF and DBT JRF.

Ayesha Rahman, PhD student, JRF-ICMR

Ayesha joined in October 2022 and works on “Effect of genetic manipulation in mammalian inner ear cells”. She completed her M.Sc. Biosciences from Jamia Millia Islamia University. She qualified ICMR JRF(AIR-51).

Sipriha Saxena (MD Biochemistry) She joined in February 2024

Key publications:

Hossain, M.M., Khalid, A., Akhter, Z. et al. Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter. J Transl Med 22, 370 (2024). https://doi.org/10.1186/s12967-024-05144-4.
yadav VS, Bhatia A, Yadav R, Makker K, Singh DK, Mir RA. Effect of initial periodontal therapy on metallothionein levels in smokers and non-smokers with periodontitis. Odontology. 2024 Apr 8. doi: 10.1007/s10266-024-00937-x
Boruah Monikongkona, Gaddam Pranitha, Agarwal Shipra, Mir Riyaz Ahmad, Gupta Ranjan, Sharma Mehar C, Deo Suryanarayana V.S, Nilima Nilima. PD-L1 expression in rare and aggressive thyroid cancers: A preliminary investigation for a role of immunotherapy. Journal of Cancer Research and Therapeutics 2023 19(2):312-320,
Morankar Rahul, Nitesh Tewari, Vijay Mathur, Atif Mohammad, Kalpana Bansal, Sandeep Agrawal, Riyaz Mir. In-vitro Evaluation for Effects of Intracanal Medicaments on Viability, Proliferation, and Differentiation of Stem Cells From Apical Papilla–A Systematic Review. European Endodontic Journal 2022 (7) 3:167-168
Mishra N, Kumar S, Singh S, Bansal T, Jain N, Saluja S, Kumar R, Bhattacharyya S, Palanichamy JK, Mir RA, Sinha S, Luthra K. Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma. PLoS Pathog. 2021 Sep 24;17(9):e1009958. doi: 10.1371/journal.ppat.1009958. PMID: 34559854; PMCID: PMC8494312.
Lone M, Shadang M, Akhter Q, Kumar M, Mallick S, Gogia A, Nilima N, Chauhan SS, Mir RA. The Expression of the RUVBL1 Component of the R2TP Complex Correlates with Poor Prognosis in DLBCL. Pathobiology. 2022;89(3):146-156. doi: 10.1159/000520723. Epub 2022 Jan 25. PMID: 35078195.
Yadav VS, Mir RA, Bhatia A, Yadav R, Shadang M, Chauhan SS, Dhingra K, Kharbanda OP, Yadav R, Garg R. Metallothionein levels in gingival crevicular fluid, saliva, and serum of smokers and non-smokers with chronic periodontitis. J Periodontol. 2021 Sep;92(9):1329-1338. doi: 10.1002/JPER.20-0314. Epub 2020 Nov 9. PMID: 33107036.
Sharma R, Kumar V, Logani A, Chawla A, Mir RA, Sharma S, Kalaivani M. Association between the concentration of active MMP-9 in pulpal blood and pulpotomy outcome in permanent mature teeth with irreversible pulpitis - a preliminary study. Int Endod J. 2021 Apr;54(4):479-489. doi: 10.1111/iej.13437. Epub 2020 Dec 13. PMID: 33128238.
Olou AA, Sarkar A, Bele A, Gurumurthy CB, Mir RA, Ammons SA, Mirza S, Saleem I, Urano F, Band H, Band V. Mammalian ECD protein is a novel negative regulator of the PERK arm of unfolded protein response. Mol Cell Biol. 2017 28;37(18). pii e00030-17
Dar MS, Singh P, Mir RA, Dar MJ. Βeta-catenin N-terminal domain: An enigmatic region prone to cancer-causing mutations. Mutat Res Rev Mutat Res. 2017 Jul;773:122-133. doi: 10.1016/j.mrrev.2017.06.001. Epub 2017 Jun 12. PMID: 28927523.
Mir RA, Lovelace J, Schafer NP, Simone PD, Kellezi A, Kolar C, Spagnol G, Sorgen PL, Band H, Band V, Borgstahl GEO. Biophysical characterization and modeling of human Ecdysoneless (ECD) protein supports a scaffolding function. AIMS Biophys. 2016;3(1):195-208. doi: 10.3934/biophy.2016.1.195. Epub 2016 Mar 9. PMID: 28492064; PMCID: PMC5421643.
Mir RA, Bele A, Mirza S, Srivastava S, Olou AA, Ammons SA, Kim JH, Gurumurthy CB, Qiu F, Band H, Band V. A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mol Cell Biol. 2015 Dec 28;36(6):886-99. doi: 10.1128/MCB.00594-15. PMID: 26711270; PMCID: PMC4810467.
Bele A, Mirza S, Zhang Y, Mir RA, Lin S, Kim JH, Gurumurthy CB, West W, Qiu F, Band H, Band V. The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells. Cell Cycle. 2015;14(7):990-1000. doi: 10.1080/15384101.2015.1006982. PMID: 25616580; PMCID: PMC4614725.
Chaturvedi NK, Mir RA, Band V, Joshi SS, Guda C. Experimental validation of predicted subcellular localizations of human proteins. BMC Res Notes. 2014 Dec 15;7:912. doi: 10.1186/1756-0500-7-912. PMID: 25510246; PMCID: PMC4301851.
Kumar R, Tripathi V, Ahmad M, Nath N, Mir RA, Chauhan SS, Luthra K. CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells. Cell Immunol. 2012;272(2):230-41. doi: 10.1016/j.cellimm.2011.09.015. Epub 2011 Oct 20. Erratum in: Cell Immunol. 2014 Aug;290(2):251. PMID: 22070874.
Mir RA, Chauhan SS. Down-regulation of a matrix degrading cysteine protease cathepsin L, by acetaldehyde: role of C/EBPα. PLoS One. 2011;6(6):e20768. doi: 10.1371/journal.pone.0020768. Epub 2011 Jun 8. PMID: 21687683; PMCID: PMC3110794.
Mittal S, Mir RA, Chauhan SS. Post-transcriptional regulation of human cathepsin L expression. Biol Chem. 2011 May;392(5):405-13. doi: 10.1515/BC.2011.039. Epub 2011 Mar 14. PMID: 21395501.
Katara R*, Mir RA*, Shukla AA, Tiwari A, Singh N, Chauhan SS. Wild-type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells. Biol Chem. 2010 Sep;391(9):1031-40. doi: 10.1515/BC.2010.103. PMID: 20536385. *Equal authorship

Dr.
Pragyan Acharya

Affiliation

Assistant Professor

Department of

Biochemistry

Contact

Phone :

91-011-26546431

Laboratory of Liver Disease Signaling and Immunology (LLDSI)

About the Principal Investigator:

Name of Faculty MemberPragyanAcharya, Ph.D.
Designation Assistant Professor
Address Room No. 3002, 3rd floor Teaching Block, Department of Biochemistry, AIIMS, New Delhi-29.
Official Phone +91-011-26546431
Email id pragyan.acharyaATaiims.edu
Social media links

https://in.linkedin.com/in/pragyan-acharya-40599b16

@Acharya3Dr

https://www.researchgate.net/profile/Pragyan-Acharya

Notable Awards and Society Memberships

GRANTS AND FELLOWSHIPS:

SERB POWER Grant 2022 towards in-depth characterization of neutrophil phenotypes in Acute-on-chronic liver failure (ACLF).
AYUSH Extramural Grant 2021 towards identification and characterization of phytomedicine preparations from Indian traditional medicines.
2016- DBT BioCARE Award
2016-DST Early Career Award
Grant for 2017 EMBO Global Exchange Lecture Course entitled Malaria Genomics and Public Health.

AWARDS AND HONORS:

Editorial Board Member, PeerJ
- Indian National Association for the Study of the Liver (INASL) 2022 Plenary Session Award for our work on biomarkers of acute kidney injury (AKI) in acute-on-chronic liver failure (ACLF)
- Indian National Association for the Study of the Liver (INASL) 2021 Plenary Session Award for our work on neutrophil phenotypes in acute-on-chronic Liver Failure (ACLF).
- Fellows Award for Research Excellence 2015- sponsored by the NIH Scientific Directors, the Office of Intramural Training & Education and FelCom/NIH.
- Fellowship in the Khorana Nirenberg Scholars Program (US-India Career Transition Award- sponsored by DBT, India and NIH, USA) 2011
- Ranbaxy Science Scholar 2010

SOCIETY MEMBERSHIPS:

Indian Society of Translational Research
Proteomics Society of India
Human Proteome Organization
Indian Immunology Society
Indian National Association for the Study of the Liver

LAB MEMBERS:

Lab members

Front : Dr. Pragyan Acharya

Back row (L to R): Nidhi Gauniyal, Shalini Sharma, Swati Srijaya Samantaray, Ditam Chakraborty, Rohini Saha, Aditya Roshan, Souvik Roy

WHAT THEY DO:

Rohini Saha- Studies neutrophil heterogeneity and its role in the Pathogenesis of Acute-on-Chronic Liver failure (ACLF). Rohini has also led some of the biomarker discovery projects in the lab.

Shalini Sharma- Studies the relationship between reactive oxygen species generation and organ dysfunctions

Ditam Chakaraborty- Studies the effect of ayurvedic formulation on the SARS-COV2 main protease in various cellular systems

Swati Srijaya Samantaray- Is involved in omics- driven biomarker discovery in organ dysfunctions and validation by various methods.

Nidhi Gauniyal- Is involved in establishing novel diagnostic methodologies for inherited liver disorders.

Aditya Roshan and Souvik Roy- are the newest additions to the lab and will be involved in studying neutrophil transmigration and NETosis respectively.

^# As Corresponding author; * As First Author

Saha R, Pradhan SS, Shalimar, Das P, Mishra P, Singh R, Sivaramakrishnan V, Acharya P^#. Inflammatory signature in acute-on-chronic liver failure includes increased expression of granulocyte genes ELANE, MPO and CD177. Sci Rep. 2021. Sep 22;11(1):18849. doi: 10.1038/s41598-021-98086-6.
Acharya P*^#, Chouhan K, Weiskirchen S and Weiskirchen R^# Cellular Mechanisms of Liver Fibrosis.Front. Pharmacol. 202112:671640. doi: 10.3389/fphar.2021.671640
Mandage R, Pramanik A, Kaur C, Sinha V, Kodan P, Singh A, Saha A, Pandey S, Wig N, Pandey RM, Soneja S, Acharya P^#. Association of Dengue and Leptospira Co-infections with Malaria Severity. Emerging Infectious Diseases 2020. 26; 8; https://doi.org/10.3201/eid2608.191214
Kaur, C, Pramanik, A, Kumari, K, Mandage R, Dinda A.K, Sankar, J, Bagga A, Agarwal, S.K., Sinha A., Singh G, Acharya P^#. Renal detection of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in malaria associated acute kidney injury: a retrospective case–control study.BMC Research Notes 2020 13, 37; doi:10.1186/s13104-020-4900-1
Singh A, Pramanik A, Acharya P, Makharia GK. Non-Invasive Biomarkers for Celiac Disease. Journal of Clinical Medicine 2019Jun 21;8(6). pii: E885; doi:10.3390/jcm8060885
Acharya P*, Kutum R, Pandey R, Mishra A, Saha R, Munjal A, Ahuja V, Mukerji M, Makharia GK. First Degree Relatives of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect them from Enterocyte Damage. Clinical and Translational Gastroenterology 2018 Oct 8;9(10):195. doi: 10.1038/s41424-018-0059-7
Alampalli S, Grover M, Chandran S, Tatu U, Acharya P^#. Proteome and Structural Organization of the Knob Complex on the Surface of the Plasmodium Infected Red Blood Cell. Proteomics- Clinical Applications 2017 Oct 5. doi: 10.1002/prca.201600177
Acharya P^#, Garg M, Kumar P, Munjal A, Raja KD. Host-Parasite Interactions in Human Malaria: Clinical Implications of Basic Research. Frontiers in Microbiology 2017 May 18;8:889. doi: 10.3389/fmicb.2017.00889. eCollection. Review.
Acharya P*, Chaubey S, Grover M, Tatu U. An exported heat shock protein 40 associates with pathogenesis-related knobs in Plasmodium falciparum infectederythrocytes. PLoS One 2012;7(9):e44605.
Acharya P*, Pallavi R*, Chandran S, Dandavate V, Sayeed S K, Rochani A, Acharya J, Middha S, Kochar S, Kochar D, Ghosh S K, Tatu U. PLoS One2011; 6(10):e26623. *These authors have contributed equally.
Pallavi R, Acharya P*, Chandran S, Daily JP, Tatu U. Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients. Malaria Journal 2010 Aug 19;9: 236.
Pesce E R, Acharya P, Tatu U, Nicoll W S, Shonhai A, Hoppe H C, Blatch G L. International Journal of Biochemistry and Cell Biology2008; 40(12): 2914-26.
Acharya P*, Kumar R, Tatu U. Chaperoning a cellular upheaval in malaria: heat shock proteins in Plasmodium falciparum. Molecular and Biochemical Parasitology 2007 Jun; 153(2):85-94. Epub 2007 Jan 17. Review.

Book Chapters

Duffy P E, Acharya P and Oleinikov A. Cytoadherence of the Malaria Parasite. Encyclopedia of Malaria. Springer Publications. 2015.
Acharya P*,Grover M and Tatu U. Systems Biology of Malaria. Encyclopedia of Systems Biology. Springer Publications. 2013.

Dr.
Ashok Sharma

Affiliation

Additional Professor

Department of

Biochemistry

Contact

Email :

ashok.sharma@aiims.edu

Phone :

91-(11)-2659-3545(off.)

09818665092 (M)

http://scholar.google.com/citations?user=3ac275cAAAAJ&hl=en

https://www.researchgate.net/profile/Ashok_Sharma12/

Dr. Sharma is an Additional Professor in the Department of Biochemistry and Posted in NCI-India/AIIMS Jhajjar Campus, AIIMS, New Delhi.He received Ph.D. in Cancer Biology at the Department of Biochemistry at All India Institute of Medical Sciences (AIIMS), New Delhi, in 2009. He is the recipient of multiple awards, including the prestigious “DBT-Ramalingaswami fellowship” and “DST-Ramanujan fellowship” awards from Govt. of India and “Outstanding Immunologist Award”, Immunocon, Indian Immunologist Society, BHU.

In 2009, he joined the Vanderbilt Medical Center, Vanderbilt University, Nashville, TN USA as a postdoctoral fellow. He worked on tight junction proteins (claudins) and their role in regulating cell migration and epithelial-mesenchymal transition (EMT). In 2012, he joined the group of Adam R Karpf at Eppley Institute, UNMC, as a senior postdoc. He is working on the epigenetics & regulation of Cancer-Testis/germline antigen POTE and its biomarkers/therapeutic potential. He has published multiple research articles and abstracts in national and international journals. He is actively involved in ePG-Pathshala, an MHRD, National Mission on Education through ICT (NME-ICT) venture to develop e-content at the postgraduate level that will help to improve the education system in India. Dr. Sharma has been the principal investigator and co-investigator in multiple projects for gynecological cancer. Dr. Sharma has been actively involved in establishing the “DBT-AIIMS/NCI-India Translational & Clinical Research Partnership Center” as PI with the help of DBT, GOI, and Early Detection Research Network (EDRN) at NCI-India with collaboration with EDRN-NCI-USA.

All India Institute of Medical Sciences (AIIMS), New Delhi, India

Jun.2005–Jan. 2009	Senior Research Fellow: Project:Effect of Bleomycin on the Expression of High Mobility Group Proteins in Benzo(a)pyrene Induced Skin Tumour "awarded & funded by Indian Council of Medical Research (ICMR- PHA/BMS/2006).
Aug. 2003-May, 2005	Junior Research Fellow: Project: Studies on Expression of HMGA Chromosomal Proteins In Cancer and Their Interaction with DNA ". Project funded by Department of Science & Technology (DST) (SP/SO/AS-55/2002), India
Aug. 2002-July 2003	Research Assistant: Project: Preferential Binding of Quinolones to DNA with Alternating G, C/A, T Sequences: A Spectroscopic Study" funded by Indian Council of Medical Research (ICMR- 58/4/97-BMS-II).

Education:

The University of Melbourne, Australia, Jun 2014

Advanced Certificate courses in “Epigenetic Control of Gene Expression."

This course addresses the basic principles of epigenetics, the role of epigenetics in biological phenomena such as imprinting, X-inactivation, cellular identity, cellular reprogramming in several organisms, and a focus on mammals. It also deciphers the interplay between epigenetic control and the environment, the role of aberrant epigenetic mechanisms in human diseases, and finally, the development of epigenetically effective drugs. The program's objective is to provide a solid foundation of information, enabling participants to design experiments when returning to their own research lab.

All India Institute of Medical Sciences (AIIMS), New Delhi, India

Ph.D. Department of Biochemistry, September 2008.

Thesis: Effect of Anticancer Agents on the Expression of High Mobility Group (HMG) Proteins in Skin Cancer”

Examined the mechanism of various anticancer agents like cisplatin, doxorubicin, Bleomycin through the expression of DNA binding high mobility group (HMGs) proteins in benzo(a)pyrene-induced squamous cell carcinoma of the skin.

I used various molecular and biochemical techniques, both In-vitro and In-vivo models, and basic microbiological and biochemical techniques and data corroborate with Magnetic Resonance Imaging in an animal model.

Results help in elucidation of the molecular mechanisms that mediate cisplatin. Doxorubicin resistance holds promise for the design of pharmacological strategies for preventing, overcoming, or reversing this form of drug resistance.

Maharshi Dayanand University, Rohtak, HR, India

Master of Science (M.Sc.) Specialization: Biochemistry, September 2001.

Dissertation: Effect of NaCl Salinity on Oxalate Metabolism in Shoot of Barley during Early Phase of Growth “. Results published in 'India Journal.'

Pt. B.D.S Post Graduate Institute of Medical Sciences, Rohtak, HR, India

D. Pharmacy, September 1999. Concentration in ’Pharmacology & Toxicology’;Pharmaceutics; Pharmaceutical chemistry; Pharmaceutical Jurisprudence; ‘Drugs store & Business Management’ and ’Hospital & Clinical Pharmacy; along with three months training as an Apprentice Pharmacist in different departments at Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana. Participated in summer’s research program resulting in dissertation and presentation.
Dissertation: Anti-dermatitis Potency of Stem Extract of Capparis deciduas

Positions Available:

Highly motivated and interested fellows and students are encouraged to inquire regarding the availability of research positions. We are seeking applications from motivated, goal-oriented individuals with excellent academic backgrounds and having their ownCSIR/DBT/ICMR/BINC/DST fellowships.Candidates with experience in Molecular Biology/Bioinformatics or other multidisciplinary are encouraged to contact and send their CV along with a cover letter at ashok[dot]sharma[at]aiims[dot]edu

Research Focus of the Lab:

Assertive discoveries have been carried out during the past decade to explore the role of epigenetic mechanisms in regulating cellular phenotype. This regulation provides the software that packages DNA, and modifications in gene expression without changing the DNA sequence of a gene. These are called epigenetic alterations. These alterations include methylation, acetylation, phosphorylation, and ubiquitylation of DNA and histone proteins (nucleosomes) as well as chromatin remodeling. "Epigenetics" refers to heritable changes in gene expression patterns without changing the primary DNA sequence. Technological advancements in genome-wide DNA sequencing, RNA sequencing for coding and non-coding expression patterns, DNA methylation and chromatin assay and assessment of all of the above with advanced bioinformatics tools are facilitating to delineate the cancer epigenome and permit key insights for developing personalized therapeutics. Our lab focuses on cancer epigenetics and is trying to decipher the epigenome regulation that may lead to the development of new epigenetic therapeutic drugs. The recent discovery of Cancer Testis/Germline (CT/CG) antigen expression in cancer suggests a strong link between gametogenesis and carcinogenesis.CG antigens can serve as biomarkers for cancer stem cells and potential targets in cancer metastatic processes as well as in the recurrence of cancer after chemotherapy. We are indulging in opening new avenues for novel Cancer Testis/Germline (CT/CG) POTE antigens to be used for cancer immunotherapy for treating gynecological cancer patients for better reproductive health. POTE (Prostate, Placenta, Ovary, and Testis-expressed) is a recently discovered gene family consisting of 14 autosomal and pericentromeric localized cancer-testis/germline antigen genes. The POTE paralogs gene family encodes proteins with cysteine-rich (CRR) domains, ankyrin repeat motifs, and α-helical regions. It is established that epigenetic mechanisms control the expression of CT/CG antigens. Epigenetic modulatory agents robustly promote the expression of CG antigens and the class-1 histocompatibility complex (MHCI).Thus, we emphasize the possible clinical use of epigenetic modulators to augment the immunotherapeutic potential of POTE family antigens and how this will ultimately improve cancer detection and treatment strategies.

Towards the mechanistic part, we are working on chromatin dynamics to be applied for answering key questions of alteration in pericentromeric localized gene expression during cancer. POTEs gene families are localized in pericentromeric regions, where duplicated genes are often abundant. Still, it is unclear how POTE paralogs escape pericentromeric repression and become expressed in cancer. Chromatin has a defined 3-D organization inside the nucleus, which guides gene expression. Although this 3D Genome organization is just recently being defined to the molecular levels, there is much to be answered in this area. Our lab is working to correlate the established molecular mechanisms for gene regulation e.g DNA methylation to be linked to the 3D genome organization inside the nucleus. It is known that there are several repressive compartments inside the nucleus where genes are dynamically located as a whole. Therefore what is the relation of epigenetic gene regulation to the gene localization and arrangement inside the nucleus? This is an inevitable question here. One such repressive compartment is nuclear lamina, where the associated sequences, called "Lamina-associated domains (LADs)" and "pericentromeric-associated domains (PADs)" are dynamically placed. We are trying to find factors responsible for these LADs /PADs formation and regulation to be applied for cancer biology. Altogether this is an entirely new area in the field of cancer biology, and studies are coming up with new fascinating facts; we are trying to be part of these strategies, with an ultimate goal to combat cancer. For further details, please visit "Laboratory of Chromatin and Cancer Epigenetics", the URL of which is at my researchgate profile.

Job/Research Experience:

July 2021- Present Aug. 2020-June, 2021	: Additional Professor- Department of Biochemistry, National Cancer Institute, Jhajjar Campus, Haryana : Associate Professor- Posted at National Cancer Institute, Jhajjar Campus, Haryana
July 2018- June, 2021	: Associate Professor- Department of Biochemistry
Dec. 2015- Aug 2020	: Faculty In-Charge, Biochemistry Diagnostic lab
Jun 2015 - Jun 2018	: Assistant Professor- Department of Biochemistry
April 2015- Jun 2015	: DBT-Ramalingaswami Fellow- Dept. of Obstetrics & Gynaecology

Postdoctoral Experience

Oct.2012-March 2015

: Postdoctoral Research Associate - Eppley Institute for Research in Cancer, UNMC, Omaha, Nebraska, USA Project focus: Mechanisms of DNA hypomethylation in ovarian cancer and evaluating its contribution to tumour progression and potential as a biomarker for the disease. ⮚ Understand the role of DNA methylation changes in cancer, with a current emphasis on epithelial ovarian cancer (EOC) ⮚ Understand the role of Lamina Associated Domain (LADs) in genomic instability ⮚ Define the mechanisms leading to activation of Cancer-Germline POTE genes in cancer ⮚ Mechanisms under the current study include DNA methylation, histone modifications, nucleosome positioning, and the interaction of epigenetic factors with transcription factor-driven oncogenic signalling mechanisms.

Jan. 2009-Oct. 2012

: VUMC Research Fellow - Department of Surgical Oncology, Vanderbilt University, Nashville, TN, USA Research focuses on "Elaborate the mechanism underlying the role of claudin 1 as a tumour promoter and metastasis in Colon cancer". ⮚ Epigenetic regulation of claudin 1 expression and role of ELAV family proteins in modulation of mRNA stability. ⮚ Explore the signalling and molecular mechanisms using anoikis as the study model, potentially applying to the in-vivo model of colon cancer metastasis and invasion. ⮚ Determine the role of APC and NOTCH signalling pathway in DSS/AOM induced IBD and cancer in claudin-1 overexpressed transgenic mice ⮚ Elaborating the mechanisms underlying using the different PKC and PKA inhibitors on the novel nuclear localization of claudin-1 in colon metastasis.

Key Publications (Selected):

http://scholar.google.com/citations?hl=en&user=3ac275cAAAAJ

Sahar Qazi, Bimal Prasad Jit, Abhishek Das, Muthukumarasamy Karthikeyan, Amit Saxena, M.D. Ray, Angel Ranjan Singh, Khalid Raza, B. Jayaram, Ashok Sharma. BESFA: bioinformatics based evolutionary, structural & functional analysis of prostrate, Placenta, Ovary, Testis, and Embryo (POTE) paralogs. Heliyon, Cell Press. 2022 Sep 5:e10476 (PMID: 36132183)
Rashmi Gupta, Bimal Prasad Jit, Santosh Kumar, Sandeep Mittan, Pranay Tanwer, M D Ray, Sandeep Mathur, Vanamail Perumal, Lalit Kumar, G K Rath, Ashok Sharma. Leveraging epigenetics to enhance the efficacy of cancer-testis antigen: a potential candidate for immunotherapy. Epigenomics, 2022 Jul;14(14):865-886. (PMID: 35872653)
Asgar Ansari, Shilpa Sachan, Bimal Prasad Jit, Ashok Sharma, Poonam Coshic, Alessandro Sette, Daniela Weiskopf, Nimesh Gupta. A highly efficient T-cell immunoassay provides assessment of B cell help function of SARS-CoV-2 specific memory CD4+ T cells. Cell Rep Methods. 2022 Jun 20;2(6):100224. doi: 10.1016/j.crmeth.2022.100224. (PMID: 35571764)
Sibi Raj, Kavindra Kumar Keshari, Arun Kumar, Brijesh Rathi, Ashok Sharma, Piyush Kumar Gupta, Saurab Kumar Jha, Niraj Kumar Jha, Petr Slama, Shubhadeep Roychoudhury, Dhruv Kumar, Molecular mechanism of regulation of c-MET/HGF signaling in head and neck cancer. Molecular Cancer, Jan 26, 2022, 10.1186/s12943-022-01503-1. (Review Article).
Dublin Lal Gupta, Ashok Sharma, Kapil Dev Soni, Syed Naqui Kazim, Sanjeev Bhoi, Dr. D.N Rao. Changes in the behaviour of monocyte subsets in acute post-traumatic sepsis patients. Mol. Immunol., 2021 Jun 1;136:65-72. (PMID: 34087625)
Asgar Ansari, Rakesh Arya, Shilpa Sachan, Someshwar Nath Jha, Anurag Kalia, Anupam Lall, Alessandro Sette, Alba Grifoni, Daniela Weiskopf, Poonam Coshic, Ashok Sharma, Nimesh Gupta. Immune memory in mild COVID-19 patients and unexposed donors reveals persistent T cell responses after SARS-CoV-2 infection. Front. Immunol. 2021 Mar 11; 12:636768. (PMID: 33777028)
Bimal Prasad Jit, Sahar Qazi, Rakesh Arya, Ankit Srivastava, Nimesh Gupta & Ashok Sharma*. An immune epigenetic insight to COVID-19 infection. Epigenomics (2021) Mar;13(6):465-480. (PMID: 33685230)
Subhadip Kundu, M.D Ray and Ashok Sharma*. The interplay between Genome organization and Epigenomic alterations of Pericentromeric DNA in Cancer. J. Genet. Genomics, (2021), Mar 6;S1673-8527 (PMID: 33840602)
Mann M, Kumar S, Chauhan SS, Gupta R, Ashok Sharma, Kumar L*. PARP-1 inhibitor modulates β-catenin signaling to enhance cisplatin sensitivity in the cancer cervix. Oncotarget. 2019 Jul 30;10(46):4802. (PMID: 31413820) (*Co-Corresponding Author)
Yogindra S Abhyankar, Rajesh Harsh, Rajendra Badwe, GK Rath, Siddhartha Laskar, Bruce Faddegon, Joseph Perl, Harald Paganetti, Jan Schuemann, Ashok Sharma, Jeffrey Buchsbaum. Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery. Physica Medica.2019, July 64:166-173 (PMID:31515016)
Ashok Sharma, Mustafa Albahrni et al. Epigenetics activation of POTE genes in ovarian cancer. Epigenetics. 2019 Feb 14. (PMID: 30764732)
Carter Barger, Wa Zhang, Ashok Sharma, Linda Chee, Smitha James, Christina Kufel, Austin Miller, Ronny Drapkin, Kunle Odunsi, David Klinkebiel, and Adam Karpf. Expression of the POTE gene family in human ovarian cancer. Sci Rep. 2018 Nov 20;8(1):17136. (PMID: 30459449)
Smitha R. James, Carlos Cedeno, Ashok Sharma, Wa Zhang, James L. Mohler, Kunle Odunsi. Elizabeth M. Wilson and Adam R. Karpf. DNA methylation and nucleosome occupancy regulate MAGEA11 expression in human cancer. Epigenetics, 2013. July, 8(8).(PMID: 23839233)
Ashok Sharma, Moorthy Krishnan Amar B. Singh, Punita Dhawan*. Trichostatin-A Modulates Claudin-1 mRNA Stability Through the Modulation of HuR and Tristetraprolin in Colon Cancer Cells. Carcinogenesis 2013 Jul 23. (PMID: 23880304)
Jillian L. Pope, Ajaz. A. Bhat, Ashok Sharma, Rizwan Ahmad, Mary K. Washington, Robert D. Beauchamp, Amar B. Singhand Punita Dhawan. Claudin-1 Regulates Intestinal Epithelial Homeostasis through the Modulation of Notch Signaling. GUT, 2013 (PMID: 23766441)
Ashok Sharma, Singh AB, Dhawan P. Claudin-1 Expression Confers Resistance to Anoikis in Colon Cancer Cells in an Src-dependent Manner. Carcinogenesis. 2012. Dec; 33(12): 2538-47. (PMID: 22941059)
Ashok Sharma, Singh AB, Krishnan M, Smith JJ, Beauchamp RD, Dhawan P. Claudin-1 regulates E-cadherin expression through ZEB-1/TCF-8/dEF-1 in Colon Cancer Cells. Gastroenterology, 2011. Dec; 141(6): 2140-53. (PMID: 21878201)
Krishnan M, Singh AB, Smith JJ, Ashok Sharma, Chen X, Eschrich S, Yeatman TJ, Beauchamp RD, Dhawan P. HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Oncogene. 2010 Jan 14; 29(2): 305-12. (PMID: 19881542)
Ashok Sharma, Ramanjaneyulu A, Ray R, Rajeswari MR. Involvement of High Mobility Group B Proteins in Cisplatin-induced Cytotoxicity in Squamous Cell Carcinoma of Skin. DNA Cell Biol. 2009 Jul; 28(7): 311-318. (PMID: 19435426)
Rajesh Vikkurthi, Asgar Ansari, Anupama R. Pai, Someshwar Nath Jha, Shilpa Sachan, Suvechchha Pandit, Bhushan Nikam, Anurag Kalia, Bimal Prasad Jit, Hilal Ahmad Parray, Savita Singh, Pallavi Kshetrapal, Nitya Wadhwa, Tripti Shrivastava, Poonam Coshic, Suresh Kumar, Pragya Sharma, Nandini Sharma, Juhi Taneja, Anil K. Pandey, Ashok Sharma, Ramachandran Thiruvengadam, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Shinjini Bhatnagar and Nimesh Gupta. Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern. Nat Microbiol. 2022 Jun 9. doi: 10.1038/s41564-022-01161-5 (PMID: 35681012)

Dr.
Archana Singh

Affiliation

Additional Professor

Department of

Biochemistry

Contact

Email :

archanasinghaiims@gmail.com

archanasinghmamc@gmail.com

Left to right: Dr.Shaikh Abdul Mubeen, Deepak Vats, Diravyaseelan M, Hema Yadav,Dr. Archana Singh, Dr. Sudhasini Panda, Alisha Arora, Faisal Shah

Academic Details:

Degree	Subject	University/ Institution	Year
M.B.B.S.	Bachelor of Medicine and Surgery	Maulana Azad Medical College, Delhi University	1998-2003
M.D.	Biochemistry	Lady Hardinge Medical College, Delhi University	2005-2008

Positions held:

Position	Department	University/ Institution	Dates
Senior Resident	Biochemistry	Lady Hardinge Medical College	27 May 2008 - 30 Dec 2009
Assistant Professor	Biochemistry	University College of Medical Sciences	31 Dec 2009 - 13 June 2014
Assistant Professor	Biochemistry	All India Institute of Medical Sciences	14 June 2014 – 30 June 2017
Associate Professor	Biochemistry	All India Institute of Medical Sciences	1 July 2017 – 30 June 2020
Additional Professor	Biochemistry	All India Institute of Medical Sciences	1 July 2020- till date

Notable Awards and Society Memberships

Life member of the Association of the Medical Biochemist of India (AMBI), Association of the Clinical Biochemists of India (ACBI), Indian Society for Atherosclerosis Research (ISAR), Indian Immunology Society

Executive Member of Indian Immunology society National body (2016-2022)
Joint Secretary of Indian Immunology Society National body(2022- 2024)
Trained on medical laboratories quality management system and Internal audit as per IS/ISO 15189 from National Institute of training for standardization, Bureau of Indian Standards, Noida, Delhi.
Worked on various aspects of complicated pregnancy (Pre-eclampsia and IUGR) and has won three awards namely Dr. C Sita Devi Award for best paper twice at Association of Clinical biochemists of India in 2010 and 2013 and International Federation of Clinical Chemistry Roche Travel Scholarship to attend and present poster at Asian Pacific Federation of Clinical Biochemistry 2013, Bali, Indonesia.
At present working in tuberculosis has got few awards won by Sudhasini Panda (PhD student) and Dr Ambrish Tiwari (MD student) which are as follows: Travel award to present paper at APFCB 2016, best paper at ACBI Delhi chapter 2016 and Dr P Usha Sharma best paper at ACBICON 2017. Won third price for AIIMS excellence Research Award 2019

Others

Involved as co-Investigator and Co-guide in other interdepartmental Extramural and Intramural projects and DM/Mch/PhD/MD/MS/MSc/MBBS thesis and research work.

Lab members (Current)

Ms. Alisha Arora (PhD student)
Mr. Deepak Vats (PhD student)
Ms. Vidushi Sharma (MSc student)
Dr. Shaikh Abdul Mubeen (Junior Resident)
Mrs. Purnima Gola (Senior Laboratory Technologist)
Karan (Lab Assistant)

Lab members (Alumni)

Ambrish Tiwari (MD)
Dr. Sudhasini Panda (PhD and MSc)

Ambrish Tiwari

Current Affiliation: Postdoctoral fellow, La Jolla Institute for Immunology, San Diego, California

3, Dr. Diravyaseelan M (M.D)

Dr. Diravyaseelan M

Current Affiliation: Senior Resident, Department of Biochemistry, AIIMS, Delhi

4 Mr. Faisal Shah (MSc)

Mr. Faisal Shah

Current Affiliation: PhD Scholar, Friedrich-Loeffler-Institute, University of Griefswald, Griefswald, Germany

5 Ms. Hema Yadav (MSc)

Ms. Hema Yadav

Current Affiliation: PhD Scholar, Department of Biochemistry, AIIMS, Delhi

Interested in taking JRF/research trainees/ MBBS summer fellows as and when funds are available

Patient Care: Presently In - charge of clinical chemistry laboratory, Department of Biochemistry, All India Institute of Medical Sciences, Delhi. Is also in charge for porphyria testing in the department.

Students presently working in Laboratory

Ms. Alisha Arora (PhD student)

Ms. Alisha Arora

Alisha completed her B.Sc.(H) in Zoology from Daulat Ram College, University of Delhi in 2017. She has completed her M.Sc. in Zoology from Hansraj College, University of Delhi in 2019. She qualified CSIR-UGC-JRF in 2017. Currently she is a third year PhD student under the guidance of Dr. Archana Singh. She is working on “Influence of different grades of hyperglycemia on innate immune responses in pathophysiology of active tuberculosis

2. Mr. Deepak Vats (PhD student)

Mr. Deepak Vats

Deepak completed his B.Sc. (H) in Zoology from Panjab University in 2017. He did his M.Sc. in Zoology from CCS Haryana Agricultural University in 2019. He qualified CSIR-NET-JRF in December 2020. Currently he is a second year PhD student under the guidance of Dr. Archana Singh. His PhD thesis is on “Study of immune response in TST (Tuberculin Skin Test) and IGRA (Interferon Gamma Release Assay) negative household contacts compared to latent TB infected household contacts of adult pulmonary tuberculosis patients

3. Ms. Vidushi Sharma (MSc student)

Ms. Vidushi Sharma

Vidushi completed her B.Sc.(H) in Biochemistry from Sri Venkateswara College, University of Delhi in 2021. She is the Delhi University Gold Medalist in the year 2021 for securing the highest marks in the B.Sc. (H) Biochemistry examinations. She had secured an All India Rank 1 in both AIIMS Biochemistry and Biotechnology entrance exams. She qualified GATE 2022 in both Biotechnology and Life Science. She is a first year M.Sc student and under the supervision of Dr. Archana Singh, she is working on her thesis titled “Study of Bdellovibrio bacteriovorus as a live antibiotic against Mycobacterium tuberculosis.”

4. Dr. Shaikh Abdul Mubeen (Junior Resident)

Dr. Shaikh Abdul Mubeen

Dr. Mubeen did his MBBS from Government Medical College and Hospital, Aurangabad. Currently he is the first year M.D. student under the guidance of Dr. Archana Singh. His thesis is focused on the “Study of Immunophenotypes of monocyte subsets in TST and IGRA negative household contacts of adult pulmonary Tuberculosis Patients.”

Research Focus of the Lab

We have worked on the genetics and immunology of pre-eclampsia and intra uterine growth restriction. We are developing new treatment modalities with respect to nitric oxide. We have published about seven original studies so far on this aspect. Her work on various aspect of complicated pregnancy has won three awards as mentioned above.

We are elucidating the biochemical, genetic and immunological host factors of tuberculosis in understanding disease pathophysiology and development of diagnostic biomarkers for identification of latent TB among household contacts. For the last seven years, we have been actively working on understanding the host factors like vitamin D, nitric oxide and iron regulatory proteins that could influence the pathophysiology of pulmonary tuberculosis (TB) with respect to the latency of infection by studying closed household contacts of TB patients. We have completed one SERB funded project “Study of vitamin D receptor (VDR) and cathelicidin expression and their correlation with Fok1 VDR polymorphism in Tuberculosis” and established a cohort of 200 pulmonary TB patients and their household contacts studying these host factors which was published as three independent research articles (Scientific Reports 2019, J Steroid Biochem Mol Biol 2019 and Ind J Clin Biochem 2021).

We are also working on the adaptive immune responses and the genetic correlates in the household contacts of active pulmonary TB patients. It would be interesting to understand why some of the household contacts do not develop tuberculosis and what are the immunological basis for the same. Thus, the findings will add bulk to the global scientific library of tuberculosis regarding the same.

We are also interested in understanding why diabetic individuals are more prone to develop tuberculosis and are studying the role of macrophage effector function in hyperglycemia to understand the same. The article regarding this work has got recently accepted for publication in the European Journal of Immunology.

We are exploring various adjunct therapies for tuberculosis treatment.

Research Projects:

Tuberculosis

Study of immune response in TST (Tuberculin Skin Test) and IGRA (Interferon Gamma Release Assay) negative household contacts compared to latent TB infected household contacts of adult pulmonary tuberculosis patients (Science and Engineering Research Board- 2022-2025, ongoing) (PI, PhD thesis)
Study of Immunophenotypes of monocyte subsets in TST and IGRA negative household contacts of adult pulmonary Tuberculosis (ICMR Financial support for MD thesis-2021, ongoing) (M.D. thesis Supervisor)
Study of effect of hyperglycemia on phenotypic and functional alteration in differentiated macrophages from THP1 cell line and monocytes from pulmonary tuberculosis patients (ICMR-2019 to 2022, ongoing) (PI, PhD thesis)
Study of Mycobacterium indicus pranii and human beta defensin 2 as adjunct and chemoimmunotherapy against Mycobacterium tuberculosis in vitro (IMRG-2019-2021, completed) (PI, M.Sc. thesis)
Study of hyperglycemia on macrophage effector function in pathophysiology of pulmonary tuberculosis (Science and Engineering Research Board-2018-2021, completed) (PI, PhD thesis)
To study the expression of nitric oxide and inducible nitric oxide synthase (iNOS) and their correlation with iNOS gene polymorphic variants in tuberculosis patients and controls (ICMR PG thesis grant, completed) (M.D. thesis Supervisor)
Study of vitamin D receptor (VDR) and Cathelicidin expression and their correlation with Fok I polymorphism in tuberculosis (PI, Science and engineering Research board, DST YSS extramural grant-2015-2018, completed) (PI, M.Sc thesis)
Serum hepcidin levels: Correlation with ferroportin expression and localization and thus iron export in pathophysiology of pulmonary tuberculosis (IMRG-2017-2018, completed) (PI, M.Sc. thesis)
Expression of Vitamin D Binding Protein (VDBP) and plasma concentration of Vitamin D in pulmonary tuberculosis (STS ICMR-2016, completed) (Supervisor STS)
TB association of India (short grant, received twice)

Publications

* Communicating Author

Archana Singh*, Deepika Sharma, Chitra Raghunandan, Jayashree Bhattacharjee. “Role of inflammatory cytokines and eNOS gene Polymorphism in pathophysiology of pre-eclampsia” . American Journal of Reproductive Immunology 2010 ; 63 (3):244-25
Deepika Sharma, Archana Singh, Shubha S. Trivedi, Jayashree Bhattacharjee “Role of Endothelin and Inflammatory Cytokines in Pre-eclampsia – A Pilot North Indian Study ” .American Journal of Reproductive Immunology 2010 ; 65(4):428-32.
Tanuj Chawla, Deepika Sharma, Archana Singh* “Role of the renin angiotensin system in diabetic nephropathy”. World J Diabetes. 2010 ; 1(5): 141-145.
Deepika Sharma, Parul Goyal, Archana Singh, Shubha S. Trivedi, Jayashree Bhattacharjee. “Intergenotypic variation of oxidative stress marker of eNOS (Glu298Asp) gene polymorphism in preeclampsia”.Anatolian Journal of Obstetrics & Gynecology 2010 ; 3:2 : ISSN 1308-8254
Deepika Sharma, Archana Singh, Shubha S. Trivedi, Jayashree Bhattacharjee. Intergenotypic Variation of Nitric Oxide and Inflammatory Markers in Preeclampsia in North Indian Population. Human Immunology 2011 ;72 (5): 436-439
Deepika Sharma, S. A. Hussain, N Akhter, Archana Singh, Shubha S. Trivedi, Jayashree Bhattacharjee. Endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism and expression in North Indian preeclamptic women. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 2013; 4(1): 65-69
Siddhamsetty AK, Verma SK, Kohli A, Verma A, Puri D, Singh A. Exploring time of death from potassium, sodium, chloride, glucose & calcium analysis of postmortem synovial fluid in semi-arid climate. Journal of forensic legal medicine. Nov 2014; 28: 11-4.
Archana Singh*, Chitra Raghunandan and Jayashree Bhattacharjee. Endothelin: link between the primary placental causes and the secondary systemic endothelial dysfunction in pathophysiology of pre-eclampsia.Obstetrics and Gynecology International Journal. June 2015; 2(3): online
Shalini Singh, Archana Singh*, Deepika Sharma, Abha Singh, M. K. Narula and Jayashree Bhattacharjee. Effect of L-Arginine on Nitric Oxide Levels in Intrauterine Growth Restriction and its Correlation with Fetal Outcome. Indian Journal of Clinical Biochemistry. July 2015; 30(3): 298-304.
Ashok Kumar Ahirwar, Anju Jain, Archana Singh, Binita Goswami, M K Bhatnagar and Jayashree Bhattacharjee. The study of markers of endothelial dysfunction in metabolic syndrome. Horm mol Biol Clin Invest Dec 2015; 24(3):131-6.
Ahirwar AK, Singh A, Jain A, Patra SK, Goswami B, Bhatnagar MK, Bhatacharjee J. Raised TSH is associated with endothelial dysfunction in Metabolic Syndrome: A case control study. Romanian Journal of Internal Medicine. June 2017, 55(4):212-221
AK Ahirwar, A Singh, A Jain, SK Patra, B Goswami, MK Bhatnagar and J Bhattacharjee. Role of Sub Clinical Hypothyroidism in Association with Adiponectin Levels Causing Insulin Resistance in Metabolic Syndrome: A Case Control Study. The Tokai journal of experimental and clinical medicine. July 2017; 42 (2): 96-103.
Ahirwar AK, Singh A, Jain A, Kaim K, Bhardwaj S, Patra SK, Goswami B, Bhatnagar MK, Bhattacharjee J. Association of prothrombotic adipokine (plasminogen activator inhibitor-1) with TSH in metabolic syndrome: a case control study. Horm Mol Biol Clin Investig. 2017 Dec 20;34(1).
Sudhasini Panda, Ambrish Tiwari, Kalpana Luthra, S. K. Sharma & Archana Singh* Association of Fok1 VDR polymorphism with Vitamin D and its associated molecules in pulmonary tuberculosis patients and their household contacts. Sci Rep 9, 15251 (2019)
Sudhasini Panda, Ambrish Tiwari, Kalpana Luthra, S. K. Sharma & Archana Singh* Status of vitamin D and the associated host factors in pulmonary tuberculosis patients and their household contacts: A cross sectional study. The Journal of Steroid Biochemistry and Molecular Biology [27 Jun 2019, 193:105419]
Abhishek Gupta, Veereshwar Bhatnagar, Anjan Kumar Dhua, Manisha Jana, Archana Singh, Rohan Malik. Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction. J Indian Assoc Pediatr Surg. 2020 Jan-Feb; 25(1): 38–42. PMC6910058
Shashi Kant, Ravneet Kaur, Farhad Ahamed, Archana Singh, Sumit Malhotra, Rakesh Kumar. Effectiveness of intravenous ferric carboxymaltose in improving hemoglobin level among postpartum women with moderate-to-severe anemia at a secondary care hospital in Faridabad, Haryana – An interventional study.
Archana Singh*, Sudhasini Panda, Diravyaseelan M, et al. Role of hyperglycemia on macrophage effector function in pathophysiology of pulmonary tuberculosis. BMC Infectious Diseases, May 20, 2020, 20(suppl 1):324
Archana Singh*, Sudhasini Panda, Ambrish Tiwari, Kalpana Luthra, S K Sharma. Vitamin D modulates innate immunity in pulmonary tuberculosis. The Journal of Immunology, May 1,2020,204 (1 supplement) 227.3
Sudhasini Panda, Shah Faisal, Krishna Kumar, Diravya M. Seelan, Alpana Sharma, Neeraj Kumar Gupta, Sudip Datta & Archana Singh*. Role of Regulatory Proteins Involved in Iron Homeostasis in Pulmonary Tuberculosis Patients and Their Household Contacts. Ind J Clin Biochem, 6 Jan 2021. https://doi.org/10.1007/s12291-020-00947-w
Yadav H, Irugu D, Ramakrishanan L, Singh A, Abraham R, Sikka K, Thakar A, Verma H. An evaluation of serum Otolin-1 & Vitamin-D in benign paroxysmal positional vertigo. Journal of Vestibular Research: Equilibrium & Orientation, 06 Mar 2021,DOI: 10.3233/ves-201601 PMID: 33720865
Ravneet Kaur, Shashi Kant, Partha Haldar, Farhad Ahamed, Archana Singh, Vignesh Dwarakanathan, Sumit Malhotra, Kapil Yadav .Single dose of IV Ferric Carboxy Maltose (FCM) prevents anemia for six months among moderately or severely anemic postpartum women: a case study from India" has been accepted for publication in Current Developments in Nutrition(CDN). Accepted M
Sudhasini Panda, Diravya M Seelan, Shah Faisal, Alisha Arora, Kalpana Luthra, Jayanth Kumar Palanichamy, Anant Mohan, Naval K Vikram, Neeraj Kumar Gupta, Lakshmy Ramakrishnan, Archana Singh*. Chronic hyperglycemia drives alterations in macrophage effector function in pulmonary tuberculosis. European Journal of Immunology (under publication-Accepted)

Dr.
Subhradip Karmakar

Affiliation

Additional Professor

Department of

Biochemistry

Contact

Email :

subhradipaiims@gmail.com

subhradip.k@aiims.edu

Phone :

91-11-2659 4027

ACADEMIC PROFILES:

ResearchGate

Google scholar

ORCID

PROFESSIONAL CAREER:

Position held	Department	University/Institution	Duration
Additional Professor	Biochemistry	AIIMS, New Delhi	2020 onwards
Associate Professor	Biochemistry	AIIMS, New Delhi	2017 to 2020
Assistant Professor	Biochemistry	AIIMS, New Delhi	2014 to 2017
Staff Scientist	Hem & Oncology	University of Chicago, USA	2011 to 2014
Research Associate	Geno & Sys Biology	University of Chicago, USA	2009 to 2011
Sr Post Doc	Genetics	Yale University	2005 to 2009

ACADEMIC PROFILE:

Degree	Department	University/Institution	Year	Remarks
PhD	Biochemistry	AIIMS, New Delhi	2004	Best Postgraduate in Clinical research
MSc	Medical Biochemistry	JIPMER, Pondicherry	1998	Honour of Merit for University 1st Rank in Masters
BSc (Hons.)	Chemistry	Calcutta University	1995

NOTABLE AWARDS:

Best Poster Award, WCC 2018, Jaipur, India
Best Poster presentation award, Drug Discovery and Development India 2015
Second best poster award, Globin Switching meeting Asilomar CA 2008
- Indian National Science Academy (INSA) young scientist award (2005) (Highest level national award for young scientist)
- Best Postgraduate in Clinical research award in PhD, 2004
- Best Oral presentation award, Indian Immunology Society meeting (2001)
- Honour of Merit for University 1st Rank in Masters (MSc)
- Endowment Award in MSc for best overall performance
- Best Postgraduate Alumni Award (1995-1998) in Dept of Biochemistry, JIPMER, India
- Qualified (1998,1999) {CSIR National Level Merit Exam for PhD fellowship}
- Qualified for the state level lectureship examination for universities
- Journal of Biomedical Sciences
- Journal of Single Cell Biology (Omics publication group)
- Annals of Clinical and Laboratory Research
- BMC Bioinformatics
- Journal of Clinical Pathology
- Journal of Molecular Cell Biology
- Chinese J of Cancer Research
- Journal of Cancer Research and Therapeutics
- Willey Science Advisor
- Asian K Medical Science
- Oncology Letters
- J Med Archives
- 1JMMD
- PLoS One
- World J of Surgical Oncology
- Asian J of Reproductive Medicine
- F1000

EDITORIAL ASSIGNMENTS:

LABORATORY PERSONNEL:

PhD scholars

Sl. No.	Personnel	Date of registration	Research area
Sl. No.	Personnel	Date of registration	Research area
1	Tryambak P. Srivastava	31-03-2018	Breast Cancer
2	Sunil Singh	13-11-2018	Placental Biology
3	Dr. Sajib Kumar Sarkar	14-11-2018	Gall Bladder Cancer
4	Neha Kashyap	24-06-2021	Placental Biology

MSc Student

Sl. No.	Personnel	Date of registration	Research area
5	Lavanya Gupta	08-09-2021	Placental Biology

Post Doc Fellows

Sl. No.	Personnel	Date of registration
6	Dr. Arnab Nayek	Bioinformatics
7	Dr. Joyeeta Talukdar	Cancer Biology
8	Dr. Rashmi	Patient derived tumor organoid cultures
9	Dr. Isha Goel	Bioinformatics

Project Fellows

Sl. No.	Personnel	Research area
10	Indrani Mukherjee	Placental Biology
11	Abhibroto Karmakar	Autoimmune disorders
12	Swati Ajmeriya	Bioinformatics
13	Aman Saifi	Renal cell carcinoma

Lab technicians

Sl. No.	Personnel	Research area
14	Vivak Kumar	Documentation and laboratory assistance
15	Deepak Kumar	Laboratory assistance

Tryambak Pratap Srivastava

Tryambak is a final-year PhD scholar in Dr. Karmakar’s laboratory. He is working on elucidating the role of the Androgen Receptor in the pathogenesis of Breast Cancer. This prospective study is carried out simultaneously in cell lines and the subjects with breast cancer undergoing surgical interventions at AIIMS, New Delhi. His doctoral research is assisted by a group of basic scientists, pathologists, surgeons; medical, surgical, and laboratory oncologists. He remains grateful to the generous funding support from the ICMR, DHR, and SERB for laboratory funding and CSIR-UGC in terms of senior research fellowship.

Tryambak obtained his B.Sc. B.Ed. dual degrees from the Regional Institute of Education, Bhubaneswar, a constituent unit of NCERT, New Delhi. Following his graduation, he joined South Asian University (SAU), New Delhi for an M.Sc. in Biotechnology. In his masters’ dissertation, he checked the efficacy of a Pfizer drug against the HIV-1 subtype C.

Tryambak advocates open access to knowledge and information. An amateur linguist, he communicates his science, blogs, and thoughts on his website and Twitter. His profile, contact information, and other relevant details can be fetched from his website.

Sunil Kumar

Mr. Sunil Singh has completed his Bachelor’s in 2015 from Deshbandhu College, University of Delhi, New Delhi. After B.Sc. he joined All India Institute of Medical Sciences (AIIMS), New Delhi as master’s Student and completed it in 2017. During M.Sc. he did his thesis under the mentorship of Dr. Subhradip Karmakar on the “Role of Peroxisome Proliferator Activated Receptor alpha (PPAR-α) in Human Trophoblast Invasion”. In 2018 he joined Dr. Subhradip Karmakar, Asst. Professor, Dept. of Biochemistry, AIIMS, New Delhi as PhD student and has started his work on understanding the role of toxic pollutants such as Sulphur dioxide and Particulate matter on the trophoblast cells and thus pregnancy and placentation. A part of his research work also warrants to identify the

transgenerational effect of these pollutants on the fetal health and growth which would be achieved by performing RNA-Seq and ChIP-Seq followed by depth in-silico analysis and animal experiments.

Dr Sajib Kumar Sarkar

Dr Sajib Kumar Sarkar (MBBS, MD, DNB) is a 4th year PhD scholar with Dr Karmakar. He did his MD in Biochemistry from MAMC, New Delhi. As a part of MD thesis he worked on in vitro and animal models of insulin resistance and observed the ameliorating effect of extract of Jamun (Syzigium cumini) seed. He completed 3 years of Senior Residency from department of Biochemistry, AIIMS, New Delhi. Presently he is exploring the molecular pathogenesis of gallbladder cancer with special focus on nuclear receptors.

Neha Kashyap

Ms. Neha Kashyap, first year Ph.D. Scholar has completed her Bachelors in Zoology Honours from “Ravenshaw University” Cuttack, Odisha. She has done her Masters in Life Sciences (Specialization in Biochemistry) from Central University of Punjab, Bhatinda. Her M.Sc. dissertation work was on the topic "miRNA mediated pathway modulation by phytochemicals: An In-silico approach" under the guidance of Dr. Shashank Kumar, Assistant Professor in the Department of Biochemistry. She got selected for the Indian Academy of Sciences “Summer Research Fellowship” project sponsored by the Indian Academy of Sciences, Bengaluru, during her graduation where she worked on the project "Analysis of Phytochemical constituents and amino acids present in green

seaweeds from South East Coast of India” under Dr.George Seghal Kiran,Assistant Professor in Pondicherry University. Later, she worked as a Junior Research Fellow (JRF) in Structural Parasitology lab, International Centre for Genetic Engineering and Biotechnology (I.C.G.E.B), New Delhi under eminent Principal Scientist Dr. Amit Sharma, Director of ICMR-NIMR in the Project "Development and validation of Hyponozite biomarkers for detecting Plasmodium vivax infection" .She also worked there on “Malarial culture and parasite proteins crystallography” .She qualified for ICMR-JRF 2020. Currently, she is working as a Ph.D. Scholar, under Dr. Subhradip Karmakar, Additional Professor in the Department of Biochemistry in All India Institute of Medical Sciences (AIIMS), New Delhi. She is working with the placenta group. Her tentative thesis is " Molecular insights into the chromatin dynamics and epigenetic changes during trophoblast fusion.”.

Lavanya Gupta

Ms Lavanya Gupta has completed her Bachelors from Sri Venkateswara College, University of Delhi in the year 2018-2021. She has done a summer internship project on “Applications of Bioinformatics in Cardiovascular Disorders for Novel Therapeutics Design under ”SRI VENKATESWARA INTERNSHIP PROGRAM FOR RESEARCH IN

ACADEMICS(SRI-VIPRA 2020) “ which included: Identification of target receptors implicated in cardiovascular diseases , compilation of ligand libraries ,Study of ADMET properties for drug-likeness and Virtual screening by docking followed by evaluation of docking energy to find best hit. She has done ADD ON COURSE -

1) “The Science of Stem cells “

2) "Fundamentals of Immunology: Innate Immunity and B-Cell Function"

3) "Understanding the Brain: The Neurobiology of Everyday Life An online course authorized by American Museum.

She was also involved in drug and development project (VISTAAR) , a science Popularisation Event organised by SVC .

Also, she was a part of mindspar ideathon event organised in Sri Venkateswara college, where she was awarded with the best presentation.

Currently, she is working as a Msc student, under Dr. Subhradip Karmakar, Additional Professor in the Department of Biochemistry in All India Institute of Medical Sciences (AIIMS), New Delhi. She is working with the placenta group. Her tentative thesis is "To study the role of estrogen regulated miRNA involved in the process of Human

Dr. Arnab Nayek

Dr. Arnab is working as a Research Associate (Bioinformatician), in the department of Biochemistry, All India Institute of Medical Sciences, New Delhi, under the guidance of Dr. Subhradip Karmakar, Additional Professor, Department of Biochemistry. He is associated with the transcriptomics (RNA-seq) data analysis from RNA sequencing data generated from the lab as well as publicly available data from the The Cancer Genome Atlas (TCGA) database, development of integrated pipelines for NGS data analysis etc. His research credentials supported with 13 publications in referred journals and his research interest includes Next generation sequencing (NGS) data analysis from human samples to improve the disease diagnosis for clinicians, development of integrated pipelines for

NGS data analysis, protein structure modelling, protein engineering, Molecular dynamics simulations.

Dr. Joyeeta Talukdar

Dr. Rashmi

Dr. Rashmi

Works on Cancer Research Related to Understand the Altruistic Mechanism and Metastasis. My focus is to understand the mechanism of cancer recurrence, and the complex biological systems that underlie its development. Further, if possible to identify new ways of treating the disease by taking a close-up look at the fundamental mechanisms at work within cells.

Dr. Rashmi Minocha has completed her Ph.D. in Biochemistry from the Ludwig Maximilian University of Munich (LMU), Germany. During the course of her Ph.D., she carried out her research work at the Gene Center, LMU Munich and at the Institute of Biochemistry, University of Gießen (Germany). The overall aim of her doctoral work was to understand how gene expression is regulated by the cross communication between its single steps using yeast as a model organism. Specifically, she worked on the biochemical and functional characterization of splicing proteins Mud2 and Prp19 complex (Prp19C).

After her Ph.D., she moved back to India and joined All India Institute

of Medical Sciences (AIIMS) in the Department of Biochemistry to pursue her interests in medical and health-based research. She is presently working as a Young Scientist Awardee (a fellowship and research grant funded by Department of Health Research). Her major research interests are:

Establishment of three-dimensional spheroid and organoid culture systems as in vitro disease models.
Using these pivotal model systems for understanding cancer pathogenesis, screening for potential drugs and investigating new strategies in the field of personalized medicine.
Applying an interdisciplinary approach by using a combination of techniques from cancer biology, molecular biology, biochemistry and bioinformatics.

Her on-going focus is to apply these 3D culture systems to investigate into the molecular mechanisms which drive gallbladder carcinogenesis.

Indrani Mukherjee

Ms. Indrani Mukherjee completed her Bachelor’s degree from Bethune College, Kolkata, the oldest women’s college in Asia with first division in Zoology. She pursued her Master’s degree in Zoology with first class from Asutosh College, University of Calcutta. Ms. Indrani completed her research training during M.Sc on the “Role of nanocapsulated flavonoidal antioxidants in combating age related cerebral ischemia-reperfusion (CIR) induced oxidative injury in rat brain” under the guidance of Dr. Nirmalendu Das, Emeritus Scientist, CSIR-Indian Institute of Chemical Biology, Kolkata. She formulated nano-encapsulated antioxidants and applied them orally to Sprague Dawley rats as a pre-treatment prior to CIR insult. She studied the rat brains for histological examinations and

expression of cellular apoptotic factors. Later, she worked under the guidance of Dr. Parasuraman Jaisankar, Senior Principal Scientist, CSIR-Indian Institute of Chemical Biology, Kolkata, in two projects. One project was entitled “A molecular docking approach to study the possible interactions between Yeast 1,4-α glucosidase and some synthetic inhibitors” where she used molecular docking to analyse the interactions between various proteins and their ligands. The second project was entitled “Isolation of enzymes from natural resources” where she used column chromatography, thin layer chromatography and HPLC for the extraction and chemical purification of phosphatases from natural resources. Ms. Indrani then worked as a Project Fellow under the guidance of Dr. Shantanu Chowdhury, Senior Principal Scientist, Functional Genomics, CSIR-Institute of Genomics and Integrative Biology, New Delhi. She focussed on learning the basic molecular biology techniques. She was involved in the amplification of pGL3 basic vector in Stbl2 strain of E.coli and its transient transfection and analysis of protein expression profile in HT 1080 cells. Currently, she is working as a PhD student under the guidance of Dr. Subhradip Karmakar, Additional Professor, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi. She is a registered Ph.D scholar of Amity University, Noida, Uttar Pradesh. Her tentative thesis is entitled as “To Investigate the Role of Reactive Oxygen Species in Development of Pre-eclampsia”. Pre- eclampsia is a leading cause of maternal and neonatal mortality and morbidity and is usually diagnosed during the last trimester of pregnancy (after 20 weeks of gestation). During Pre-eclampsia, trophoblast cell migration and invasion into the maternal decidua, and vessels are typically incomplete, and thus angiogenesis and trophoblast cell proliferation are impaired. The shallow trophoblastic invasion induces placental ischemic reperfusion injury due to irregular uterine blood flow which results in the generation of reactive oxygen species (ROS). Therefore, her hypothesis is that excessive ROS generation along with an alteration of cytokine and hormonal levels in the uterine microenvironment, might contribute to the pathogenesis of Pre-eclampsia. Ms. Indrani was also awarded with CSIR-Senior Research Fellowship in the year 2019 and served as the Cultural Secretary of Society of Young Scientists (SYS), AIIMS, New Delhi, for the year 2020-2021.

Abhibroto Karmakar

Systemic Lupus Erythematosus is a chronic, autoimmune disease with wide clinical presentation. Lupus widely affects many organs and system with no cure. The main area of our study is understanding the genomic stratification and drug responds between the patients with lupus. We keen to explore the molecular aspect of patients during lupus flare and remission. We are also looking at single nucleotide polymorphism in SLE patients focusing on Indian population. Apart from my PhD we are looking at the role of nuclear receptor in pathogenesis of gall bladder cancer.

Apart from science I love teaching dance, recitation and writing poems. I love to do solo travelling and cooking give me zeal to life. I believe education is important for all in this regard I made an YouTube channel

creating medical awareness and do career counselling in field of life sciences.

Swati Ajmeriya

Aman Saifi

Swati Ajmeriya is working as Senior Research fellow at Department of Biochemistry, AIIMS under Dr. Subhradip Karmakar. She did her masters in Biotechnology. She does research in the area of genomics using bioinformatic tools and techniques. She has worked on high-throughput exome, transcriptome and metagenomics data. She has good command over linux scripting, R and python programming. She also develops pipelines for rapid processing of genomics data. Swati's research work is primarily involved in transcriptomics and statistical genomics with applications to the identification of differentially expressed genes and genetic variants conferring susceptibility to diseases by discovering variants, genes and pathways from high-throughput data.

Mr Aman Saifi is working as a Junior Research Fellow on a project called "Molecular Analysis to explore resistance against receptor tyrosine kinase inhibitors (RTKI) in Renal Cell Carcinoma (RCC) and the prognostic role of circulating tumour cells in patients with metastatic RCC (mRCC). He has completed his Bachelor's and Master's Integrated Degree in Biotechnology from Amity University, Uttar Pradesh. He qualified GATE exam in 2021 as well as in 2022. His university awarded him a merit scholarship during his coursework. He was selected for the summer internship program at Jawaharlal Nehru University. He worked on the project "standardizing the IR64 rice seeds tissue culture protocol for the plant transformation with Agrobacterium tumefaciens harbouring pCAMBIA1304 vector". Later, for his master's thesis, he worked on the project "standardization of differentiation of bone cell precursors (macrophages and mesenchymal stem cells) into mature bone cells (osteoclast and osteoblast cells)" in the department of Biotechnology, AIIMS

ALUMNI:

Sl. No.	Personnel	Duration	Work
MD-PhD graduates
1	Dr. Karthikeyan Pethusamy	2016-2022	AML
2	Dr. Ashikh Seethy	2017-2022	MDS
MD graduate
3	Dr. Ankita Raj	2015-2018	Placental Biology
Senior Resident
4	Dr. Ashok Kumar Ahirwar	2014-2017	Placental Biology

RESEARCH DOMAINS OF THE LABORATORY:

Molecular Oncology:

The laboratory employs classic molecular biology tools assisted with in silico tools to elucidate pathogenesis of various cancer including Breast Cancer, Gall Bladder Cancer, AML etc. The breast cancer project studies the cellular and molecular events pertaining to the Androgen Receptor-mediated events in Breast Cancer cell lines and validating the same in tumor obtained post-surgery. In GBC, we are exploring the role of Nuclear Receptors in the pathophysiology of gallbladder cancer and its implication in the severity of the disease. We are also investigating tumor infiltrating lymphocytes in the same. In vitro study on gallbladder cancer cell lines alteration of different phenotypic properties like migration, invasion, proliferation, apoptosis etc following treatment with different drugs targeting nuclear receptors.

PUBLICATIONS:

Dhar, Ruby; Talukdar, Joyeeta; Nayek, Arnab; Ajmeriya, Swati; Kumar, Arun; Karmakar, Subhradip; 2022 Unveiling the omicron B. 1.1. 529: the variant of concern that is rattling the globe Asian Journal of Medical Sciences 13(1), pp.166-168
Pethusamy, Karthikeyan; Dhar, Ruby; Kumar, Arun; Karmakar, Subhradip; 2022 Cell to cell hijacking: Role of membrane nanotubes Asian Journal of Medical Sciences 13(1), pp.44593
Dhar, Ruby; Kumar, Arun; Karmakar, Subhradip; 2022 How COVID pandemic may end: Co-existence is the key Asian Journal of Medical Sciences 13(2), pp.44593
Ajmeriya, Swati; Kumar, Amit; Karmakar, Subhradip; Rana, Shweta; Singh, Harpreet; 2022 Neutralizing Antibodies and Antibody-Dependent Enhancement in COVID-19: A Perspective Journal of the Indian Institute of Science, pp.42736
Dhar, Ruby; Talukdar, Joyeeta; Kumar, Arun; Karmakar, Subhradip; 2022 The problem with APC and open access: Hurdles in publishing practice Asian Journal of Medical Sciences 13(3), pp.44593
Dhar, Ruby; Kumar, Arun; Karmakar, Subhradip; 2022 The innocence of Omicron: Taking the right decision Asian Journal of Medical Sciences 13(3), pp.170-171
Guha, Samudra; Talukdar, Joyeeta; Karmakar, Abhibrato; Goswami, Sandeep; Kumar, Arun; Dhar, Ruby; Karmakar, Subhradip; 2022 Synthetic biology: The new era Asian Journal of Medical Sciences 13(4), pp.200-203
Bharat, SS; Makkar, N; Karmakar, S; Singh, AK; 2022 A novel technique to widen the 1st web space by using 'spare parts' of thumb polydactyly Sri Lanka Journal of Surgery 40(1), pp.
Talukdar, Joyeeta; Srivastava, Tryambak Pratap; Gogoi, Gayatri; Rai, Avdhesh; Dhar, Ruby; Karmakar, Subhradip; 2022 Oncometabolite profiling identifying estrogen-responsive genes in breast cancer, pp.
Singh, Sunil; Dhar, Ruby; Karmakar, Subhradip; 2022 Fenofibrate mediated activation of PPARα negatively regulates trophoblast invasion Placenta 126, pp.140-149
Srivastava, Tryambak Pratap; Dhar, Ruby; Srivastava, Anurag; Deo, SVS; Parshad, Rajinder; Karmakar, Subhradip; 2022 Functional characterization of Androgen Receptor splice variants in breast cancer invasion and metastasis Cancer Research 82(12_Supplement), pp.6398-6398
Dhar, Ruby; Rana, Shweta; Srivastava, Tryambak Pratap; Nayek, Arnab; Sharma, Jai Bhagwan; Kaur, Digjeet; Kalari, Krishna R; Singh, Harpreet; Karmakar, Subhradip; 2022 India’s Opportunities and Challenges in Establishing a Twin Registry: An Unexplored Human Resource for the World’s Second-Most Populous Nation Twin Research and Human Genetics, pp.44805
Talukdar, D; Haldar, AK; Dastidar, R; Kumar, S; Lodha, M; Banerjee, A; Karmakar, S; Sikder, K; 2022 Inflammation-related Biomarkers Are Associated With Severity Of Idiopathic Dilated Cardiomyopathy (IDCM): A Brief Report On Patients Of West Bengal, India Journal of Cardiovascular Disease Research, pp.1693-1701
Sahoo, Om Saswat; Pethusamy, Karthikeyan; Pratap Srivastava, Tryambak; Talukdar, Dr; Alqahtan, Mohammed S; Abbas, Mohamed; Dhar, Ruby; Karmakar, Subhradip; 2022 The metabolic addiction of cancer stem cells Frontiers in Oncology, pp.3655
Mukherjee, Indrani; Singh, Sunil; Biswas, Subhrajit; Talukdar, Joyeeta; Alqahtani, Mohammed S; Abbas, Mohamed; Nag, Tapas Chandra; Mridha, Asit; Gupta, Surabhi; Sharma, Jai Bhagwan; 2022 Monosodium glutamate (MSG) perturbs trophoblast differentiation and invasion program through a ROS mediated pathway, pp.
Jalandra, Rekha; Dhar, Ruby; Pethusamy, Karthikeyan; Sharma, Minakshi; Karmakar, Subhradip; 2022 Dysbiosis: Gut feeling F1000Research 11, pp.911
Talukdar, Joyeeta; Srivastava, Tryambak; Karmakar, Abhibrato; Purkaystha, Kakali; Goswami, Sandeep; Kumar, Arun; Dhar, Ruby; Karmakar, Subhradip; 2022 Malaria vaccine: The tale of terror, triumph, tyranny, and trust Asian Journal of Medical Sciences 13(9), pp.252-257
Pethusamy, Karthikeyan; Seethy, Ashikh; Dhar, Ruby; Karmakar, Abhibroto; Chaudhary, Shilpi; Bakhshi, Sameer; Chopra, Anita; Chauhan, Shyam S; Karmakar, Subhradip; 2022 Loss of TET2 with reduced genomic 5-hmC is associated with adverse-risk AML Leukemia & Lymphoma, pp.44743
Seethy, Ashikh A; Singh, Sunil; Mukherjee, Indrani; Pethusamy, Karthikeyan; Purkayastha, Kakali; Sharma, Jai Bhagwan; Sharma, Radhey S; Dhar, Ruby; Karmakar, Subhradip; 2021 Potential SARS-CoV-2 interactions with proteins involved in trophoblast functions – an in-silico study Placenta 103, pp.141-151
Nayak, Brusabhanu; Panaiyadiyan, Sridhar; Singh, Prabhjot; Karmakar, Subhradip; Kaushal, Seema; Seth, Amlesh; 2021 Role of circulating tumor cells in patients with metastatic clear-cell renal cell carcinoma Urologic Oncology: Seminars and Original Investigations 39(2), pp.135.e9-135.e15
Pethusamy, Karthikeyan; Seethy, Ashikh A; Kulandhasamy, Maheshwari; Garg, Pinki; Chowdhury, Debashish; Agarwal, Sarita; Kumar, Arun; Dhar, Ruby; Karmakar, Subhradip; 2021 Effects of 469E/K
polymorphism of ICAM1 gene in ischemic stroke and its association with stroke severity and outcome Asian Journal of Medical Sciences 12(1), pp.44744
Chattopadhyay, Indranil; Dhar, Ruby; Pethusamy, Karthikeyan; Seethy, Ashikh; Srivastava, Tryambak; Sah, Ramkishor; Sharma, Jyoti; Karmakar, Subhradip; 2021 Exploring the role of gut microbiome in colon cancer Applied biochemistry and biotechnology 193(6), pp.1780-1799
Dhar, Ruby; Jee, Babban; Karmakar, Subhradip; 2021 Balancing Healthcare and Economy Amidst the COVID-19 Pandemic: An Indian Experience Risk Management and Healthcare Policy 14(), pp.827
Seethy, Ashikh; Pethusamy, Karthikeyan; Chattopadhyay, Indranil; Sah, Ramkishor; Chopra, Anita; Dhar, Ruby; Karmakar, Subhradip; 2021 TETology: epigenetic mastermind in action Applied Biochemistry and Biotechnology 193(6), pp.1701-1726
Jee, Babban; Dhar, Ruby; Singh, Sunil; Karmakar, Subhradip; 2021 Heat shock proteins and their role in pregnancy: Redefining the function of “Old Rum in a New Bottle” Frontiers in Cell and Developmental Biology 9(), pp.648463
Panaiyadiyan, Sridhar; Nayak, Brusabhanu; Singh, Prabhjot; Kaushal, Seema; Karmakar, Subhradip; Seth, Amlesh; 2021 Prognostic and predictive role of intra-tumoral CXCR1 expression in patients receiving tyrosine kinase inhibitors for metastatic clear-cell renal cell carcinoma Journal of Clinical Urology (), pp.20514158211012200
Talukdar, Joyeeta; Karmakar, Abhibroto; Dhar, Ruby; Kumar, Arun; Karmakar, Subhradip; 2021 Non-Government Organizations (NGO)-The gap fillers during COVID-19 lockdown in Assam, India Asian Journal of Medical Sciences 12(6), pp.115-121
Dhar, Ruby; Pethusamy, Karthikeyan; Talukdar, Joyeeta; Karmakar, Abhibrato; Kumar, Arun; Karmakar, Subhradip; 2021 The curious case of COVID-19: Its murky origin, negligence and a botched international attempt for a cover-up Asian Journal of Medical Sciences 12(7), pp.146-148
Dhar, Ruby; Seethy, Ashikh; Singh, Sunil; Pethusamy, Karthikeyan; Srivastava, Tryambak; Talukdar, Joyeeta; Rath, Goura Kishor; Karmakar, Subhradip; 2021 Cancer immunotherapy: Recent advances and challenges Journal of Cancer Research and Therapeutics 17(4), pp.834
Dhar, Ruby; Kumar, Arun; Karmakar, Subhradip; 2021 Menopause and COVID19 severity: The missing link Asian Journal of Medical Sciences 12(9), pp.44621
Mukherjee, Indrani; Dhar, Ruby; Singh, Sunil; Sharma, Jai Bhagwan; Nag, Tapas Chandra; Mridha, Asit Ranjan; Jaiswal, Parul; Biswas, Subhrajit; Karmakar, Subhradip; 2021 Oxidative stress-induced impairment of trophoblast function causes preeclampsia through the unfolded protein response pathway Scientific reports 11(1), pp.43831
Dhar, Ruby; Pethusamy, Karthikeyan; Jee, Babban; Karmakar, Subhradip; 2021 Fault Lines in India’s COVID-19 Management: Lessons Learned and Future Recommendations Risk Management and Healthcare Policy 14(), pp.4379
Dhar, Ruby; Kumar, Arun; Karmakar, Subhradip; 2021 Spatial transcriptomics: Gene expression in space, time and numbers Asian Journal of Medical Sciences 12(11), pp.44593
Saluja, Sumedha; Singh, Jay; Jain, Ayushi; Chaudhary, Shilpi; Pethusamy, Karthikeyan; Chattopadhyay, Parthaprasad; Bakhshi, Sameer; Chopra, Anita; Singh, Archna; Karmakar, Subhradip; 2021 Delineating the Role of Interplay between m6A Machinery Genes and IGF2BP Group of RNA-Binding Proteins in B-Cell Acute Lymphoblastic Leukemia (B-ALL) Blood 138(), pp.4472
Dhar, Ruby; Kumar, Arun; Karmakar, Subhradip; 2021 The science of “smell” and the noble for “hugs:” making “sense?” Asian Journal of Medical Sciences 12(12), pp.44593
Bagri, Narendra Kumar; Karmakar, Subhradip; Haldar, Partha; Lodha, Rakesh; Kabra, SK; 2021 Role of serum MRP8/14 in predicting response to methotrexate in children with juvenile idiopathic arthritis JCR: Journal of Clinical Rheumatology 27(8), pp.e336-e341
Deka, Kamalika Bhandari; Sarma, Pallavi; Sarma, Anupam; Das, Gaurav; Karmakar, Subhradip; Rath, Goura Kishore; Rai, Avdhesh Kumar; 2021 Prevalence of Epstein–Barr virus in North-East Indian breast cancer patients' blood Annals of Oncology Research and Therapy 1(2), pp.111
Sil, Suparba; Dhar, Ruby; Karmakar, Subhradip; 2021 The Perils of the Pandemic and India's Child Victims of Covid-19 International Journal of Child Health and Nutrition 10(4), pp.148-153
Seethy, Ashikh A; Singh, Sunil; Mukherjee, Indrani; Pethusamy, Karthikeyan; Purkayastha, Kakali; Sharma, Jai Bhagwan; Dhar, Ruby; Karmakar, Subhradip; 2020 An In Silico Analysis of Potential SARS-CoV-2 Interactions with Proteins Involved in Placental Functions (), pp.
Dhar, Ruby; Sinha, Akhauri Yash; Seethy, Ashikh; Matta, Sri Anusha; Pethusamy, Karthikeyan; Srivastava, Trymbak; Singh, Sunil; Mukherjee, Indrani; Sarkar, Sajib; Minocha, Rashmi; 2020 Genotypic and antigenic study of SARS-CoV-2 from an Indian isolate bioRxiv (), pp.
Karmakar, Subhradip; Dhar, Ruby; Jee, Babban; 2020 Covid-19: research methods must be flexible in a crisis bmj 370(), pp.
Karmakar, Subhradip; Dhar, R; Purkayastha, K; Seth, R; Karmakar, S; 2020 To investigate the role of BRAF V600eco-occurring mutations in Langerhans cell histiocytosis (LCH) Cancer Research 80(16_Supplement), pp.3127-3127
Dhar, Ruby; Singh, Sunil; Mukherjee, Indrani; Pethusamy, Karthikeyan; Purkayastha, Kakali; Das, Prasenjit; Sharma, Jai Bhagwan; Sharma, Radhey Shyam; Karmakar, Subhradip; 2020 MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation Frontiers in Bioscience-Landmark 26(4), pp.717-743
Dhar, Ruby; Jee, Babban; Pethusamy, Karthikeyan; Seethy, Ashikh; Kumar, Arun; Karmakar, Subhradip; 2020 The scars of COVID19: Preparing for the collateral damages Asian Journal of Medical Sciences 11(6), pp.142-147
Sathe, Gajanan; George, Irene A; Deb, Barnali; Jain, Ankit P; Patel, Krishna; Nayak, Brusabhanu; Karmakar, Subhradip; Seth, Amlesh; Pandey, Akhilesh; Kumar, Prashant; 2020 Urinary glycoproteomic profiling of non-muscle invasive and muscle invasive bladder carcinoma patients reveals distinct N-glycosylation pattern of CD44, MGAM, and GINM1 Oncotarget 11(34), pp.3244
Dhar, Ruby; Jee, Babban; Talwar, Gursaran Pran; Karmakar, Subhradip; 2020 Repurposing anti-tuberculosis and anti-leprosy vaccine against COVID-19 disease: an Indian experience Current Science 119(7), pp.1078
Dhar, Ruby; Mukherjee, Indrani; Singh, Sunil; Goswami, Sandeep; Karmakar, S; 2019 Role of Carbon Monoxide Signaling During trophoblast Invasion in Humans Open Access Journal of Reproductive Systems and Sexual Disorders 2(2), pp.186-191
Dhar, Ruby; Rath, Goura Kishor; Karmakar, Subhradip; 2019 FBXO4 as a novel ubiquitin ligase that targets Cyclin D in the pathogenesis of breast cancer.(), pp.
Dhar, Ruby; Pethusamy, Karthikeyan; Singh, Sunil; Mukherjee, Indrani; Seethy, Ashikh; Sengupta, Bharoti; Srivastava, Tryambak; Sarkar, Sajib; Mandal, Vikramjit; Karmakar, Madhumita; 2019 Draft genome of Ompok bimaculatus (Pabda fish) BMC Research Notes 12(1), pp.44621
Zhou, Ying; Unno, Kenji; Hyjek, Elizabeth; Liu, Hui; Zimmerman, Todd; Karmakar, Subhradip; Putt, Karson S; Shen, Jiayin; Low, Philip S; Wickrema, Amittha; 2018 Expression of functional folate receptors in multiple myeloma Leukemia & lymphoma 59(12), pp.2982-2989
Kathuria, S; Karmakar, S; Singh, A; Singh, SP; 2017 Squamous cell carcinoma arising from hypertrophic lichen planus Indian Dermatology Online Journal 8(4), pp.288
Dhar, R; Karmakar, S; 2016 Role of a novel ubiquitin ligase FBXO4 in pathogenesis of breast cancer EUROPEAN JOURNAL OF CANCER 54(), pp.S14-S14
Karmakar, S; 2016 Reduced DOCK4 expression leads to erythroid dysplasia in -7/del(7q) myelodysplastic syndromes EUROPEAN JOURNAL OF CANCER 54(), pp.S46-S47
Sundaravel, Sriram; Duggan, Ryan; Bhagat, Tushar; Ebenezer, David L; Liu, Hui; Yu, Yiting; Bartenstein, Matthias; Unnikrishnan, Madhu; Karmakar, Subhradip; Liu, Ting-Chun; 2015 Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes Proceedings of the National Academy of Sciences 112(46), pp.E6359-E6368
Li, Guoqiang; Ci, Weimin; Karmakar, Subhradip; Chen, Ke; Dhar, Ruby; Fan, Zhixiang; Guo, Zhongqiang; Zhang, Jing; Ke, Yuwen; Wang, Lu; 2014 SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer Cancer cell 25(4), pp.455-468
Karmakar, S; 2014 Cell Based Immunotherapy: As a Promising Futuristic Solution for Effective Cancer Therapy Omics International 3(1), pp.105
McNerney, Megan E; Brown, Christopher D; Wang, Xiaoyue; Bartom, Elizabeth T; Karmakar, Subhradip; Bandlamudi, Chaitanya; Yu, Shan; Ko, Jinkyung; Sandall, Barry P; Stricker, Thomas; 2013 CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia Blood, The Journal of the American Society of Hematology 121(6), pp.975-983
Liu, Li; Karmakar, Subhradip; Dhar, Ruby; Mahajan, Milind; Choudhury, Alina; Weissman, Sherman; Pace, Betty S; 2013 Regulation of Gγ-globin gene by ATF2 and its associated proteins through the cAMP-response element PloS one 8(11), pp.e78253
Prasad, Sandip; Karmakar, Subhradip; Cai, Yi; Vander Griend, Donald; White, Kevin; Eggener, Scott; 2012 SPECKLE-TYPE POZ PROTEIN CYTOPLASMIC MISLOCALIZATION AND OVEREXPRESSION PROMOTE TUMOR GROWTH IN AN ORTHOTOPIC MURINE RENAL CELL CANCER MODEL The Journal of Urology 187(4S), pp.e60-e60
Landt, Stephen G; Marinov, Georgi K; Kundaje, Anshul; Kheradpour, Pouya; Pauli, Florencia; Batzoglou, Serafim; Bernstein, Bradley E; Bickel, Peter; Brown, James B; Cayting, Philip; 2012 ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia Genome research 22(9), pp.1813-1831
McNerney, Megan E; Brown, Christopher D; Wang, Xiaoyue; Karmakar, Subhradip; Bandlamudi, Chaitanya; Yu, Shan; Anastasi, John; Le Beau, Michelle M; White, Kevin; 2012 Abstract LB-411: RNA sequencing reveals CUX1 to be a conserved tumor suppressor in acute myeloid leukemia associated with loss or deletion of chromosome 7 Cancer Research 72(8_Supplement), pp.LB-411-LB-411
McNerney, Megan E; Brown, Christopher D; Wang, Xiaoyue; Karmakar, Subhradip; Bandlamudi, Chaitanya; Yu, Shan; Anastasi, John; Le Beau, Michelle M; White, Kevin; 2012 RNA sequencing reveals CUX1 to be a conserved tumor suppressor in acute myeloid leukemia associated with loss or deletion of chromosome 7 CANCER RESEARCH 72(), pp.
ENCODE Project Consortium; 2012 An integrated encyclopedia of DNA elements in the human genome Nature 489(7414), pp.57
Stricker, TP; Brown, CD; Montoya, V; McNerney, M; Kittler, R; Karmakar, S; Grossman, RL; White, KP; 2011 A Complex Genetic Basis for Breast Cancer Subtypes LABORATORY INVESTIGATION 91(), pp.65A-65A
ENCODE Project Consortium; 2011 A user's guide to the encyclopedia of DNA elements (ENCODE) PLoS biology 9(4), pp.e1001046
Ramakrishnan, Valya; Liu, Li; Karmakar, Subhradip; Mahajan, Milind; Weissman, Sherman M; Pace, Betty; 2010 The Role of p38 MAPK/CREB1 Signaling In γ-Globin Gene Regulation Blood 116(21), pp.1012
Karmakar, Subhradip; Mahajan, Milind C; Schulz, Vincent; Boyapaty, Gokul; Weissman, Sherman M; 2010 A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus The EMBO journal 29(19), pp.3260-3271
Mahajan, Milind C; Karmakar, Subhradip; Newburger, Peter E; Krause, Diane S; Weissman, Sherman M; 2009 Dynamics of α-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34+ cells in culture Experimental hematology 37(10), pp.1143-1156. e3
Das, Chandana; Chaudhuri, Snehamay; Karmakar, Madan; Chakraborty, Sudipta; 2008 Uterine arteriovenous malformation as a rare cause of menorrhagia Online Journal Of Health And Allied Sciences 7(3), pp.
Mahajan, Milind C; Karmakar, Subhradip; Weissman, Sherman M; 2008 Chromatin Structure and Transcription of the Human Alpha Globin Locus during Erythroid Differentiation Blood 112(11), pp.3575
Karmakar, Subhradip; Mahajan, Milind C; Weissman, Sherman M; 2007 Recruitment of Rad50 and MCM Complexes on the Human Beta Globin Locus Control Region (LCR): A Novel Role for LCR Hypersensitive Site 4 (HS4).(), pp.
Karmakar, Subhradip; Mahajan, Milind C; Weisman, Sherman M; 2007 Recruitment of RAD50 and MCM complexes on the human beta globin locus control region (LCR): A novel role for LCR hypersensitive site (HS4) BLOOD 110(11), pp.87A-87A
Dhar, Ruby; Karmakar, Subhradip; Sriraman, Rajan; Talwar, Gursaran Prasad; Das, Chandana; 2004 Efficacy of a Recombinant Chimeric Anti-hCG Antibody to Prevent Human Cytotrophoblasts Fusion and Block Progesterone Synthesis American Journal of Reproductive Immunology 51(5), pp.358-363
Karmakar, Subhradip; Dhar, Ruby; Das, Chandana; 2004 Inhibition of cytotrophoblastic (JEG-3) cell invasion by interleukin 12 involves an interferon γ-mediated pathway Journal of Biological Chemistry 279(53), pp.55297-55307
Karmakar, Subhradip; Das, Chandana; 2004 Modulation of ezrin and E-cadherin expression by IL-1β and TGF-β1 in human trophoblasts Journal of reproductive immunology 64(44593), pp.47362
Karmakar, Subhradip; Das, Chandana; 2002 Regulation of trophoblast invasion by IL-1β and TGF-β1 American Journal of Reproductive Immunology 48(4), pp.210-219

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Dr. Sujata Mohanty

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Dr. Karthikeyan P

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3. Dr Kuntal Chakraborty (Final year MD Student):

4. Dr Prachi Priyadarshini (Final year MD student):

5.Dr Khushboo Sharma (Second year MD student):

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2. Dr Astha Sachan (Senior Resident):

3. Dr Kuntal Chakraborty (Final year MD Student):

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Dr. Pramod Kumar Gautam

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https://orcid.org/0000-0001-7580-8846

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Dr. Riyaz Ahmad Mir

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Dr. Pragyan Acharya

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Laboratory of Liver Disease Signaling and Immunology (LLDSI)

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Dr. Ashok Sharma

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Sujata Mohanty

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Karthikeyan P

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Siddhartha Kundu

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Rakhee Yadav

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Pramod Kumar Gautam

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Riyaz Ahmad Mir

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Pragyan Acharya

Dr.
Ashok Sharma

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Archana Singh

Dr.
Subhradip Karmakar