
Dr.
K. Ramachandran
Male
Affiliation
Professor
Department of
Biostatistics
Professor from Oct. 1973 to Jan. 1991

Prof.
Hariprasad G.
Male
Affiliation
Professor
Department of
Biophysics
Contact
Email :
g.hariprasad@rediffmail.com
dr.hariprasadg@gmail.com
Phone :
+91-11-26594029
Office Address
Room No. 11, 5th Floor, Porta Cabin, Teaching Block, AIIMS, New Delhi
Recent Employment Details (Past few years):
- Assistant Professor - Biophysics - 29/06/2012 to 30/06/2015 at Department of Biophysics, All India Institute of Medical Sciences, New Delhi
- Associate Professor – Biophysics - 01/07/2015 to 30/06/2018 at Department of Biophysics, All India Institute of Medical Sciences, New Delhi
- Additional Professor – Biophysics - 01/07/2018 to Till Date at Department of Biophysics, All India Institute of Medical Sciences, New Delhi
Brief Research Area:
- Current pharmacological interventions in Parkinson’s disease and schizophrenia aim to restore normal dopamine levels, overshooting of which results in adverse effects. We have identified potential biomarkers that can monitor pharmaco-efficacy in the two diseases. We are currently looking to take a step further by developing CHIP based monitoring kits to monitor therapy in the two disease states.
- We have previously structurally characterized group III PLA2s from Humans, scorpions, and Clorenchis sinensis. We are currently looking structurally characterize PAF-AH enzyme, a PLA2 family analog, that is implicated in certain protozoal infections. The detailed characterization will pave the way for design of specific and potent inhibitory molecules against these drug targets.
Selected Publications/Patents (Last 5 years):
Google Scholar Link
- Koley T, Goswami A, Kumar M, Upadhyay N, Hariprasad G*. Comparative structural analysis of human ACE2 receptor with spike protein of SARS-CoV-2 variants: Implications to understand infectivity of the virus. Advances and Applications in Bioinformatics and Chemistry (2022) 15: 21-27.
- Kaushik A , Bandyopadhyay S, Porwal C, Srinivasan A, Rukmangadachar LA, Hariprasad G, Kola S, Kataria J, Singh UB. 2D-DIGE based urinary proteomics and functional enrichment studies to reveal novel Mycobacterium tuberculosis and human protein biomarker candidates for pulmonary tuberculosis Biochemistry Biophysics Research Communications (2022) 619:15-21.
- Pathania S, Khan MI, Bandyopadhyay S, Singh SS, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Vanamail P, Hariprasad G*. iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer. Scientific Reports (2022) 12(1):8625.
- Koley T, Kumar M, Goswami A, Ethayathulla AS, Hariprasad G*. Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virus. Biochemical and Biophysics Research Communications. (2022) 592:51-53.
- Naqvi AAT, Fatima K, Mohammad T, Fatima U, Singh IK, Singh A, Atif SM, Hariprasad G, Hasan GM, Hassan MI. Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach. BBA Molecular Basis of Disease (2020) 1866: 165878.
- Khan MI, Hariprasad G*. Structural Modeling of Wild and Mutant Forms of Human Plasma Platelet Activating Factor-Acetyl Hydrolase Enzyme. Journal of Inflammation Research. (2020) 13:1125-1139.
- Khan MI, Hariprasad G*. Human Secretary Phospholipase A2 Mutations and Their Clinical Implications. Journal of Inflammation Research. (2020) 13: 551-561.
- Patania S, Khan MI, Kumar A, Gupta AK, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Hariprasad G*. Proteomics of sentinel lymph nodes in early breast cancer for identification of thymidylate synthase as a potential biomarker to flag metastasis: A preliminary study. Cancer Management and Research (2020) 12: 4841–4854.
- Gupta AK, Pokhriyal R, Das U, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in CSF to monitor pharmaco-therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2073-2085.
- Gupta AK, Pokhriyal R, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Cerebrospinal fluid proteomics for identification of α2-macroglobulin as a potential biomarker to monitor pharmacological therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2853-2867.
- Gupta AK, Kumar GK, Rani K, Pokhriyal R, Khan MI, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Mohanty AK, Hariprasad. G*. 2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine dictated states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15: 1031-1044.
- Gupta AK, Rani K, Swarnkar S, Kumar GK, Khan MI, Pokhriyal R, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Hariprasad G*. Evaluation of Serum Apolipoprotein E as a Potential Biomarker for Pharmacological Therapeutic Efficacy Monitoring in Dopamine Dictated Disease Spectrum of Schizophrenia and Parkinson's disease: A Preliminary Study. J Cent Nerv Syst Dis. (2018) 10:1179573518803585. eCollection.

Dr.
Sharmistha Dey
Female
Affiliation
Professor
Department of
Biophysics
Contact
Email :
sharmistha_d@hotmail.com
Phone :
+91-11-26546435
Office Address
Department of Biophysics, AIIMS, New Delhi
Brief Research Area:
Blood based biomarker of neurodegenerative diseases and cancers and their therapeutic intervention.
- ICMR award 2016 “Professor Surindar Mohan Marwah Award- 2016 for outstanding work carried out in the field of Biogerontology
- Five AIIMS Excellent Awards in 2012, 2014, 2015, 2017, 2018 for best paper research publications
- First prize in AIIMS Oncology award 2018.
Selected Publications/Patents (Last 5 years):
Google Scholar Link
- Abhinay Kumar Singh, Atul Batra, Ashish Datt Upadhaya, Subhash Gupta, Haresh K P and Sharmistha Dey, Circulatory Level of Inflammatory Cytoskeleton Signaling Regime Proteins in Cancer Invasion and Metastasis. Front. Oncol. 2022; 12:851807. doi: 10.3389/fonc.2022.851807
- Masroor Anwar, Rashmita Pradhan, Sharmistha Dey, Rahul Kumar. The Role of Sirtuins in Sarcopenia and Frailty Ageing and Disease. 2022; Volume 14, Number 1; doi.org/10.14336/AD.2022.0622
- Sharmistha Dey, Abhay Kumar Singh, Abhinay Kumar Singh, Kartik Rawat, Joyita Banerjee, Vertica Agnihotri, Deepak Upadhaya. Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention. Medical Oncology 2022; 39:30. doi.org/10.1007/s12032-021-01633-4
- Pradhan R, Singh AK, Kumar P, Bajpai S, Pathak M, Chatterjee P, Dwivedi S, Dey AB, Dey S. Blood Circulatory Level of Seven Sirtuins in Alzheimer's Disease: Potent Biomarker Based on Translational Research. Mol Neurobiol. 2022 Jan 7. 59, pages1440–1451. doi: 10.1007/s12035-021-02671-9. Citation: 2
- Kumari S, Singh A, Singh AK, Yadav Y, Bajpai S, Kumar P, Upadhyay AD, Shekhar S, Dwivedi S, Dey AB, Dey S. Circulatory GSK-3β: Blood-Based Biomarker and Therapeutic Target for Alzheimer's Disease. J Alzheimers Dis. 2022;85(1):249-260. doi: 10.3233/JAD-215347
- Masroor Anwar, Saumya Ranjan Mallick, Daizy Paliwal, Shashank Shekhar, Subrat Kumar Panda, Sharmistha Dey, Aparajit Ballav Dey. Impact of physical activity on mitochondrial enzymes, muscle stem cell and anti-oxidant protein Sestrins in Sarcopenic mice. Experimental Gerontology. 2021, Volume 150, 111358. DOI: 10.1016/j.exger.2021.111358. Citation: 3
- Kumar R, Tiwari V, Dey S. Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's Disease. Eur J Neurosci. 2021 doi: 10.1111/ejn.15569. Online ahead of print.
- Banerjee J, Gupta A, Agnihotri V, Pradhan R, Kandel R, Upadhyay AD, Dwivedi S, Kumar L, Dey S, Dey AB. Lung cancer in the older population:Interactive effects of angiotensin converting enzyme gene polymorphism (rs 4340 ID) and tobacco addiction in risk assessment. Indian J Cancer. 2021 Jun 21. doi: 10.4103/ijc.IJC_1082_19. Online ahead of print.
- Pradhan R, Yadav SK, Prem NN, Bhagel V, Pathak M, Shekhar S, Gaikwad S, Dwivedi SN, Bal CS, Dey AB, Dey S. Serum FOXO3A: A ray of hope for early diagnosis of Alzheimer's disease. Mech Ageing Dev. 2020;190:111290. doi: 10.1016/j.mad.2020.111290. Citation: 6
- Rajan SP, Anwar M, Jain B, Khan MA, Dey S, Dey AB. Serum sestrins: potential predictive molecule in human sarcopenia. Aging Clin Exp Res. 2020, 33, 1315-1324. doi: 10.1007/s40520-020-01642-9. Citation: 4
- Singh AP, Nigam L, Yadav Y, Shekhar S, Subbarao N, Dey S. Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson's disease. Mol Divers. 2020; 25, 2261-2270. doi: 10.1007/s11030-020-10116-z. Citation: 2
- Vertica Agnihotri, Abhishek Gupta, Lalit Kumar, Sharmistha Dey. Serum sHLA-G: Significant diagnostic biomarker with respect to therapy and immunosuppressive mediators in Head and Neck Squamous Cell Carcinoma. Sci Rep. 2020; 10: 3806. Published online 2020 Mar 2. doi: 10.1038/s41598-020-60811-y. Citation: 6
- Rai N, Dey S. Protective response of Sestrin under stressful conditions in aging. Ageing Res Rev. 2020; 64:101186. doi: 10.1016/j.arr.2020.101186. Citation: 5
- Nitish Rai, Ashish Datt Upadhyay, Vinay Goyal, Sadanand Dwivedi, Aparajit Ballav Dey, Sharmistha Dey Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson's Disease. J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):690-695. doi: 10.1093/gerona/glz234. Citation: 13
- Shekhar S, Dey S Induction of p73, Δ133p53, Δ160p53, pAKT lead to neuroprotection via DNA repair by 5-LOX inhibition. Mol Biol Rep. 2020; 47(1), 269-274. doi: 10.1007/s11033-019-05127-5. Citation: 4
- Singh AP, Ramana G, Bajaj T, Singh V, Dwivedi S, Behari M, Dey AB, Dey S. Elevated Serum SIRT 2 May Differentiate Parkinson's Disease From Atypical Parkinsonian Syndromes. Front Mol Neurosci. 2019;12:129. doi: 10.3389/fnmol.2019.00129. eCollection 2019. Citation: 7
- Sahu V, Mohan A, Dey S. p38 MAP kinases: plausible diagnostic and prognostic serum protein marker of non small cell lung cancer. Exp Mol Pathol. 2019;107:118-123. Citation: 6
- Shekhar S, Yadav Y, Singh AP, Pradhan R, Desai GR, Dey AB, Dey S. Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway. Exp Gerontol. 2018;110:277-283. Citation: 16
- Sahu V, Nigam L, Agnihotri V, Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S. Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same. Cancer Res Treat. 2019; 51(1):313-325. doi: 10.4143/crt.2018.105. Citation: 15
- Singh AP, Bajaj T, Gupta D, Singh SB, Chakrawarty A, Goyal V, Dey AB, Dey S. Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson's Disease: A Pilot Study. Neuromolecular Med. 2018;20(1):83-89. doi: 10.1007/s12017-017-8475-5. Citation: 17
- Rai N, Venugopalan G, Pradhan R, Ambastha A, Upadhyay AD, Dwivedi S, Dey AB, Dey S. Exploration of Novel Anti-Oxidant Protein Sestrin in Frailty Syndrome in Elderly. Aging Dis. 2018; 9(2):220-227. doi: 10.14336/AD.2017.0423. Citation: 21
- Shekhar S, Yadav SK, Rai N, Kumar R, Yadav Y, Tripathi M, Dey AB, Dey S. 5-LOX in Alzheimer's Disease: Potential Serum Marker and In Vitro Evidences for Rescue of Neurotoxicity by Its Inhibitor YWCS. Mol Neurobiol. 2018;55(4):2754-2762. doi: 10.1007/s12035-017-0527-1. Citation: 12
- Kumar R, Nigam L, Singh AP, Singh K, Subbarao N, Dey S. Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease. Eur J Med Chem. 2017;127:909-916. doi: 10.1016/j.ejmech.2016.11.001. Citation: 31
- Kumar S, Sharma VK, Yadav S, Dey S. Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway. Chem Cent J. 2017;11(1):56. doi: 10.1186/s13065-017-0281-5. Citation: 13
- Vertica Agnihotri, Abhishek Gupta, Rahul Kumar, Ashish Datt Upadhyay, Sadanand Dwivedi, Lalit Kumar, Sharmistha Dey. Promising link of HLA-G polymorphism, tobacco consumption and risk of Head and Neck Squamous Cell Carcinoma (HNSCC) in North Indian population. Human Immunology 78 (2017) 172–178. Citation: 18
- Gupta A, Agnihotri V, Kumar R, Upadhyay AD, Bhaskar S, Dwivedi S, Dey S. Effects of Tobacco Habits on the Polymorphism of NFKB1 and NFKB1A Gene of Head and Neck Squamous Cell Carcinoma in Indian Population. Asian Pac J Cancer Prev. 2017;18(7):1855-1859. Citation: 18
- Pradhan R, Kumar R, Shekhar S, Rai N, Ambashtha A, Banerjee J, Pathak M, Dwivedi SN, Dey S, Dey AB. Longevity and healthy ageing genes FOXO3A and SIRT3: Serum protein marker and new road map to burst oxidative stress by Withania somnifera. Exp Gerontol. 2017;95:9-15. May 2012. Volume 3, Issue 2, 2012, pp.-49-54. Citation: 10

Prof.
Sujata Sharma
Female
Affiliation
Professor
Department of
Biophysics
Contact
Email :
sujatasharma.aiims@gmail.com
sujatasharma@aiims.edu
Phone :
+91-11-26594608
Office Address
Room No. 9, Department of Biophysics, AIIMS, New Delhi
Brief Research Area:
Antimicrobial therapeutics, Protein Structure based drug design, Nanomedicine.
Wikipedia page
- TWAS Regional Awards in the subject area “Public Understanding and Popularization of Science (2021)
- Peaklife Women Inspire Award (2021)
- SERB Power Fellowship (2021)
- Kalpana Chawla Excellence Award (2020)
- National Bioscientist Award for Career Development (NBACD) given by Department of Biotechnology, Government of India (2011)
- National Woman Bioscientist Award given by Department of Biotechnology, Government of India (2007)
- Woman Scientist Award given by Biotech Research Society of India (BRSI) (2006)
Selected Publications/Patents (Last 5 years):
- Ahmad N, Singh A, Gupta A, Pant P, Singh TP, Sharma S, Sharma P. Discovery of the Lead Molecules Targeting the First Step of the Histidine Biosynthesis Pathway of Acinetobacter baumannii. J Chem Inf Model. (2022) 62:1744-1759.
- Smith ML, Sharma S, Singh TP. Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection. Scand J Immunol. (2022) 95:e13111.
- Sikarwar J, Singh J, Singh TP, Sharma P, Sharma S. The mechanism of action of Lactoferrin - Nucleoside Diphosphate Kinase complex in combating biofilm formation. Protein Pept Lett. (2022) Aug 16. doi: 10.2174/0929866529666220816160517.
- Singh PK, Ahmad N, Yamini S, Singh RP, Singh AK, Sharma P, Smith ML, Sharma S, Singh TP. Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase. Protein Sci. (2022) 31:384-395.
- Singh J, Maurya A, Singh PK, Viswanathan V, Ahmad MI, Sharma P, Sharma S, Singh TP. A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 Å Resolution. Protein J. (2021) 40:857-866.
- Smith, M. L., Sharma, S., & Singh, T. P. Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections. Eur. J. Clin. Nutr. (2022). 1–2. 76(4):629-630.
- Gupta A, Vijayan V, Pant P, Kaur P, Singh TP, Sharma P, Sharma S. Structure prediction and discovery of inhibitors against phosphopantothenoyl cysteine synthetase of Acinetobacter baumannii. J Biomol Struct Dyn. (2021) Aug 4:1-13
- Singh A, Ahmad N, Varadarajan A, Vikram N, Singh TP, Sharma S, Sharma P. Lactoferrin, a potential iron-chelator as an adjunct treatment for mucormycosis - A comprehensive review. Int J Biol Macromol. (2021) Sep 30;187:988-998.
- Singh J, Vijayan V, Ahmedi S, Pant P, Manzoor N, Singh TP, Sharma P, Sharma S. Lactosmart: A Novel Therapeutic Molecule for Antimicrobial Defense. Front Microbiol. (2021) 12:672589.
- Gupta A, Sharma P, Singh TP & Sharma S. Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochim Biophys Acta Proteins Proteom (2021) 1869:140566.
- Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S & Singh TP Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Protein J. (2021) 40:8-18.
- Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S & Singh TP. Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution. J Biol Inorg Chem (2021) 26: 149-159
- Sharma P, Singla A, Gupta A, Khan NI, Rani C, Singh TP & Sharma S. Biophysical characterization of Type III Pantothenate kinase (PanK) from Acinetobacter baumannii. Protein Pept Lett (2021) 28(4), 450-458.
- Sharma P, Vijayan V, Pant P, Sharma M, Vikram N, Kaur P, Singh TP, Sharma S. Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2. J Biomol Struct Dyn. 2020; 3:1-11
- Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP. Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. (2019) 1867:537-547.
- Pandey SN, Iqbal N, Singh PK, Rastogi N, Kaur P, Sharma S & Singh TP. Binding and structural studies of the complexes of type 1 ribosome inactivating protein from Momordica balsamina with uracil and uridine. Proteins. (2019) 87:99-109.
- Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S & Singh TP. A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. (2018) 644:72-80
- Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Kaur P, Sharma S & Singh TP. Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J. (2018) 475:547-560.
- Singh PK, Iqbal N, Sirohi HV, Bairagya HR, Kaur P, Sharma S & Singh TP. Structural basis of activation of mammalian heme peroxidases. Prog Biophys Mol Biol. (2018)133:49-55.
- Singh PK, Sirohi HV, Iqbal N, Tiwari P, Kaur P, Sharma S, Singh TP. Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution. Biochim Biophys Acta. (2017) 1865:329-335.
- Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP. Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol. (2017) 94:459-465.
- Khan SH, Islam A, Hassan MI, Sharma S, Singh TP, Ahmad F.Effect of conservative mutations (L94V and L94I) on the structure and stability of horse cytochrome c. Arch Biochem Biophys. (2017) 633:40-49
- Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP. Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. (2017) 85:1882-1890.
- Singh RP, Singh A, Sirohi HV, Singh AK, Kaur P, Sharma S, Singh TP. Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases - structural determination of the lactoperoxidase-methimazole complex at 1.97 Å resolution. FEBS Open Bio. (2016) 6:640-50.
- Rastogi N, Singh A, Singh PK, Tyagi TK, Pandey S, Shin K, Kaur P, Sharma S, Singh TP. Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination. Proteins. (2016) 84:591-9.
List of Books:
- Warriors in White (11 January 2021). ISBN 978-1-637455-11-1.
- A Dragonfly's Purpose. (12 September 2019). ISBN 978-1-64650-765-8.
- The Secret of the Red Crystals. (16 October 2017). ISBN 978-1-947988-83-5
- Kovi’s Promise (21 November 2021) ISBN 979-8-885037-77-8
- Tumhara Bholu (23 November 2021) ISBN 979-8-885039-02-4

Dr.
Savita Yadav
Female
Affiliation
Professor
Department of
Biophysics
Contact
Email :
savitayadav@aiims.edu
savita11@gmail.com
Phone :
+91-11-26596445
Office Address
Room No. 3004, 3rd Floor, Teaching Block
Recent Employment Details (Past few years):
- Professor, since 2014
- Additional Professor, 2010-2014
- Associate Professor, 2007-2010
- Assistant Professor, 2003-2007
Brief Research Area:
Proteomics, Biomarker discovery and Functional Biophysics:
- For early detection of diseases, specifically, idiopathic male infertility, recurrent pregnancy loss, and gynaecological cancers.
- To gain molecular insights into sperm functions, causes of infertility, and progression of gynaecological cancers.
- SERB POWER Fellowship, Fellow National Academy of Medical Sciences, Fellow Indian Academy of Biomedical Sciences
- Prof. S. S. Guraya Memorial Oration award 2019
- AIIMS excellence prize in Oncology 2019 under Basic Science category
- G.P. Talwar award for Middle Career Scientist 2015
- AIIMS Research excellence award 2012, 2013
Selected Publications/Patents (Last 5 years):
Google Scholar Link
- Chhikara N, Tomar AK, Datta SK, Yadav S. Proteomic changes in human spermatozoa during in vitro capacitation and acrosome reaction in normozoospermia and asthenozoospermia. Andrology. 2022 Sep 4. doi:10.1111/andr.13289. Epub ahead of print. PMID: 36057948.
- Naglot S, Tomar AK, Singh N, Yadav S. Label-free proteomics of spermatozoa identifies candidate protein markers of idiopathic recurrent pregnancy loss. Reprod Biol. 2021;21(3):100539.
- Saini A, Chandra KB, Kumar V, Mathur SR, Sharma JB, Kumar S, Yadav S. Analysis of Multimerin 1 (MMRN1) expression in ovarian cancer. Mol Biol Rep. 2020;47(12):9459-9468.
- Jain P, Ojha SK, Kumar V, Bakhshi S, Singh S, Yadav S. Differential seminal plasma proteome signatures of acute lymphoblastic leukemia survivors. Reprod Biol. 2019;19(4):322-328.
- Sinha A, Singh V, Singh S, Yadav S. Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males. Life Sci. 2019;218:81-88.

Dr.
Tony George Jacob
Male
Affiliation
Professor
Department of
Anatomy
Tony joined AIIMS as faculty in 2014. He is continuing his work on the pathogenesis of pancreatitis. Now, he and his team have also established two surgical models of acute pancreatitis in rats at the Institute, which also measures organ dysfunction. He is also working on two models of chronic pancreatitis. His work includes the role of autophagy, cell death and inflammation in the pathogenesis of acute and chronic pancreatitis. He also studies the development and effect of aging on the various components of the human auditory system.
He is interested in teaching various aspects of anatomy and has a special interest in history, especially that of medical education. He is also a resource person for Mentoring, Interpersonal Communication Skills and Personality Development in the Health Sector and also for medical research, writing a manuscript and the process of reviewing and editing.
Chapter in books:
- Changing populations of neurons and glia in human cochlear nucleus with aging- Chapter 12
- Morphology of the human pancreas during development and aging- Chapter 4 P.C Rath, R. Sharma, S. Prasad Eds: Topics in Biomedical Gerontology.
- Parija SC, Adkoli BV Eds: Effective Medical Communication- the ABCD of it. Chapter: Jacob TG, Sahni P: Publishing effectively and ethically. Springer Singapore. 2020. pp 123-130. doi: 10.1007/978-981-15-3409-6.
- Indrapal, Paltati CRB, Saini S, Kaur C, Kumar P, Bhardwaj DN, Jacob TG, Roy TS. Morphological and neurochemical changes in GABAergic neurons of the aging human inferior colliculus. Hearing Research. 2019. March 2019. Hearing Research 377. DOI:10.1016/j.heares.2019.02.005
- Poorna Pillutla SV, Kaur C, Roy TS, Jacob TG. Estimation of Volume of Stria Vascularis and the Length of Its Capillaries in the Human Cochlea. J Microsc Ultrastruct. 2019 Jul-Sep;7(3):117-123. doi: 10.4103/JMAU.JMAU_12_19. PMID:31548922
- Saini S, Kaur C, Pal I, Kumar P, Jacob TG, Thakar A, Roy KK, Roy TS. Morphological development of the human cochlear nucleus. Hear Res. 2019 Oct; 382:107784. doi: 10.1016/j.heares.2019.107784. Epub 2019 Aug 20. PMID:31522073
- Kaur C, Saini S, Pal I, Kumar P, Sati HC, Jacob TG, Bhardwaj DN, Roy TS. Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion. Hearing Res. 2020. https://doi.org/10.1016/j.heares. 2020.107883
- Kumar A, Faiq MA, Krishna H, Raj GV, Kishan V, Coffey JC, Jacob TG. Development of a Novel Technique to Dissect the Mesentery that Preserves Mesenteric Continuity and Enables Characterization of the Ex Vivo Mesentery. Front. Surg. 2020. doi: 10.3389/fsurg.2019.00080
- Ahuja R, Sharma N, Vashisht P, Jacob TG, Narang R, Bhatnagar N. Biocompatibility Analysis of PLA based Candidate Materials for Cardiovascular Stents in a Rat Subcutaneous Implant Model. Acta Histochemica. 2020;122(7):151615. doi: 10.1016/j.acthis.2020.151615
- Raghav R, Jain R, Jacob TG, Dhawan A, Roy TS. Co-administration of nalbuphine attenuates the morphine-induced anxiety and dopaminergic alterations in morphine-withdrawn rats. Psychopharmacology (Berl). 2021 Apr;238(4):1193-1211. doi: 10.1007/s00213-021-05765-3
- Nag HL, Jain G, Vijayakumar V, Jacob TG, Sonai M, Lalwani S. Femoral Intercondylar Notch: Gross Anatomy and Histology of the Connective Tissue Lining of its Roof: A Pilot Study. Surg Rad Anat. 2021. doi.org/10.1007/s00276-021-02757-y.
- Kumar P, Sharma S, Kaur C, Pal I, Bhardwaj DN, Vanamail P, Roy TS, Jacob TG. The ultrastructural study of human cochlear nerve at different ages. Hearing Research 2022. (in press). https://doi.org/10.1016/j.heares.2022.108443
- M. Uppal, T.G. Jacob, H.N. Yadav, S.K. Datta, R. Yadav, S.J. Mahapatra, P. Garg, P. Sahni, Therapeutic Methylprednisolone and Infimab Decrease the Severity of Organ Dysfunction in Pancreatic Duct Ligation Model of Severe Acute Pancreatitis in Wistar Rats, HPB, Volume Supplement 3, 2021, Page S739, ISSN 1365-182X, https://doi.org/10.1016/j.hpb.2021.08.136.
- Sharma MK, Priyam K, Kumar P, Garg PK, Roy TS, Jacob TG. Effect of calorie-restriction and rapamycin on autophagy and the severity of caerulein-induced experimental acute pancreatitis in mice. Front. Gastro (Therapy in Gastroenterology). 2022. Accepted for publication.

Prof.
Ritu Sehgal
Female
MS Anatomy
Affiliation
Professor
Department of
Anatomy
Additional Responsibility
receptors expression in breast cancer and medical education
Dr. Ritu Sehgal graduated from Maulana Azad Medical College (MAMC) and completed her MS Anatomy and Senior Residency from the same institution. She was awarded the ‘Pyare Lal Sharma & Bishan Devi Gold Medal’ for Best thesis/student in Pre & Paraclinical Subjects. She joined AIIMS as Assistant Professor of Anatomy after working for a brief period as Assistant Professor at VMMC, New Delhi
- Kumar A, Sehgal R, Roy TS. A morphometric analysis and study of variations of foramina in the floor of the middle cranial fossa. J Anat Soc India 2016; 65(2): 143-147.
- Deshmukh VR, Singh S, Sehgal R. Cysto-duodeno-colic ligament and its clinical relevance. Biomed J 2016; 39(6): 414-416.

Prof.
T.C. Nag
Male
Affiliation
Professor
Department of
Anatomy
Additional Responsibility
Age-related structural and neurochemical changes in the human retina and factors associated with them, and the impact of iron accumulation through aging, and various effects of exposure to bright prolonged light on the retina in animal models (chicks and rodents).
Dr TC Nag received his doctoral degree (1991) from the University of Calcutta, Kolkata. He was a postdoctoral fellow in the Department of Biology, University of Montréal, Canada (1993) and later worked as a research associate and Pool Officer in Neurobiology Laboratory at the Department of Anatomy, AIIMS, New Delhi (1995-1998). He also worked as a lecturer in West Bengal Educational Service (1998-2001) after which he joined as an assistant professor in the electron microscopy section of the department (2001). He is a recipient of Shakuntala Amir Chand Prize of ICMR (1999), SS Parmar Foundation Award and JR Bhattacharjee Award of Indian Academy of Neurosciences and AIIMS Research excellence award (2015) and is a member of National Academy of Sciences, Allahabad and Associate Editor, Journal of Biochemical and Molecular Toxicology (Wiley).
- Gupta CL, Nag TC, Jha KA, Kathpalia P, Maurya M, Kumar P, Gupta S, Roy TS (2020) Changes in the inner retinal cells after intense and constant light exposure in Sprague-Dawley rats. Photochem Photobiol 96: 1061-1073.
- Nag TC, Kathpalia P, Wadhwa S (2020) Microtubule alterations may destabilize photoreceptor integrity: Age-related microtubule changes and pattern of expression of MAP-2, Tau and hyperphosphorylated Tau in aging human photoreceptor cells. Exp Eye Res 198:108153.
- Maurya M, Nag TC, Kumar P, Roy TS (2021) Expression patterns of iron regulatory proteins after intense light exposure in a cone-dominated retina. Mol Cell Biochem 476: 3483-3495.
- Nag TC (2021) Pathogenic mechanisms contributing to the vulnerability of aging human photoreceptor cells. Eye 35: 2917-2929.
- Nag TC, Gorla S, Kumari C, Roy TS (2021) Aging of the human choriocapillaris: Evidence that early pericyte damage can trigger endothelial changes. Exp Eye Res 212:108771.

Prof.
Renu Dhingra
Female
PhD
Affiliation
Professor
Department of
Anatomy
Dr Renu Dhingra joined BSc (Hons) Human Biology at AIIMS, then completed her MSc (Anatomy) at AIIMS, followed by a PhD. She further worked as a Senior Demonstrator in the Department of Anatomy, AIIMS. Later, she joined University College of Medical Sciences, New Delhi as a Lecturer and thereafter at Gulf Medical College Ajman, UAE. Subsequently, she joined the department of Anatomy at AIIMS as an Assistant Professor.
Her research interest is in placental biology. At present, she is working on ‘apoptotic, oxidative endoplasmic reticulum stress and angiogenetic markers in pre –eclampsia . Her current research also focuses on migration and invasion studies on trophoblastic cells. The laboratory has the infrastructure for handling cell lines, conducting in-vitro assays, apoptotic, cytotoxic assays and other molecular biology techniques like ELISA, Immunofluorescence, Western Blot and PCR.
She has established the Plastination laboratory in the department. The plastinated specimens serve as valuable adjuncts for teaching Anatomy to undergraduate and postgraduate students.
- Arora P, Dhingra R, Bhatla N, Sharma A. VEGF and sFlt-1 polymorphisms in Preeclampsia. Placenta 2016; 45: 118–119
- Arora P, Kshetrapal P, Bhatla N, Rani N, Mochan S, Gupta SK, Saxena S, Dhingra R. Matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase- 2 mRNA levels in early onset preeclampsia. Placenta 2017; 51:131-132
- Gupta SK, Bhatla N, Rani N, Mochan S, Saxena S, Arora P, Dhingra R. Hydrogen sulphide producing enzymes are decreased in placentas from preeclampsia. Placenta. 2017; 51: 131.
- Mochan S, Bhatla N, Rani N, Gupta SK, Saxena S, Arora P, Dhingra R. SFLT-1 induces endoplasmic reticulum stress by activating perk pathway in bewo cells Placenta. 2017; 51: 131.

Prof.
Arundhati Sharma
Female
M. Sc, B. Sc
Affiliation
Professor
Department of
Anatomy
Prof. Arundhati Sharma did her graduation (B. Sc) and post graduation (M. Sc) in Genetics and Molecular Biology from Osmania and Pune University, respectively. She did her Ph D in Human Genetics from Nizam’s Institute of Medical Sciences and did her subsequent post doctoral work in the Department of Medical Genetics, SGPGIMS, Lucknow. Later, she joined as Assistant Professor of Genetics in the Department of Anatomy, AIIMS. Her work includes teaching, training and providing diagnostic facilities in the field of Human genetics. Her laboratory provides the following:
Diagnostic and patient care services- conventional cytogenetic services (Karyotyping) and other chromosomal studies. Molecular cytogenetic services using fluorescent in-situ hybridization (FISH) for various genetic numerical and structural abnormalities, cancers and other genetic conditions. Research interests include genetics of various endocrine and eye disorders, identification of biomarkers for prognostic and diagnostic purposes for various cancers and adverse drug reactions, and studies of Addiction genetics, i.e. identification of the genetic contribution to alcohol and drug dependence.
- Marik B, Bagga A , Sinha A , Khandelwal P , Hari P , Sharma A. Genetic and clinical profile of patients with hypophosphatemic rickets. Eur J Med Gen 21 June 2022. https://doi.org/10.1016/j.ejmg.2022.104540.
- Vanathi M, Kishore A, Gupta Y, Setty PB, Sen S, Nag TC, Gupta R, Sharma A, Tandon R. Recurrence in Reis Bücklers corneal dystrophy: Clinicopathological correlation. Indian J Ophthalmol Case Rep 2022; 2:371-5.
- Chakraborty S, Sharma A, Bagchi I, Pal S, Bhattacharyya C, Gupta V, Maitra A, Bhattacharjee S, Sharma A, Sihota R, Acharya M. A genomewide association study on individuals with occludable angles identifies potential risk loci for intraocular pressure. J Genet. 2021;100:69. PMID: 34608871
- Sarkar S, Singh R, Sharma A, Pandit MA, Gupta R, Singhal D, Jain R, Balhara YP. Association of Serotonergic Pathway Gene Polymorphisms With Behavioral Parameters in Patients With Opioid Dependence. Cureus. 2021 Nov 6;13(11):e19310. doi: 10.7759/cureus.19310. PMID: 34900485; PMCID: PMC8647861
- Gupta V, Somarajan BI, Kaur G, Gupta S, Singh R, Pradhan D, Singh H, Kaur P, Sharma A, Chawla B, Pahuja A, Ramachandran R, Sharma A. Exome sequencing identifies procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 mutations in primary congenital and juvenile glaucoma. Indian J Ophthalmol. 2021 Oct;69(10):2710-2716. doi: 10.4103/ijo.IJO_1750_21. PMID: 34571620; PMCID: PMC8597539.
- Gupta V, Somarajan BI, Gupta S, Walia GK, Singh A, Sofi R, Chaudhary RS, Sharma A. The mutational spectrum of Myocilin gene among familial versus sporadic cases of Juvenile onset open angle glaucoma. Eye (Lond). 2021;35(2):400-408.
- Grover T, Gupta R, Arora G, Bal CS, Ambekar A, Ray SB, Vaswani M, Sharma A. Dopamine transporter availability in alcohol and opioid dependent subjects – a 99mTc-TRODAT1SPECT imaging and genetic association study. Psychiatry Res Neuroimaging. 2020; 305:111187. doi: 10.1016/j.pscychresns.2020.111187. Online ahead of print.