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Saroj Kumar

Affiliation

Additional Professor
Department of
Biophysics

Contact

Email :
sarojgupta.k@gmail.com
Phone :
+91-11-26594240 (O)

Additional Responsibility

Office Address

Room No: 3011, 3rd Floor, Teaching Block, Department of Biophysics, All India Institute of Medical Sciences, New Delhi - 110029

General OPD

Special Clinic

Surgery Days

Speciality of work

Areas of teaching

Areas of teaching

Recent Employment Details (Past few years):

  • Associate Professor (2019 - Present): Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
  • Assistant Professor (2016 - 2019): Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
  • Project Leader (2015 - 2016): Department of Engineering Science, Uppsala University, Sweden.
  • Post-Doctoral Fellow (2014 - 2015): Canadian Light Source, Saskatoon, Canada.
  • Post-Doctoral Fellow (2011 - 2014): Université Libre de Bruxelles, Brussels, Belgium.

Brief Research Area:

Dr Saroj has established the infrared-based bio-imaging laboratory for bio diagnosis. Initiated to develop the exosome-based diagnostic and therapeutic modalities for neurodegenerative (Parkinson’s and Alzheimer's) and cancer diseases. His laboratory becomes a leading place for exosome-based research.

  • ICMR-DHR International Short-Term Fellowship in Foreign Institutes, 2022-2023 awarded by ICMR-DHR, Ministry of Health & Social Welfare for 3 months.
  • Adjunct Professor (2021 – Present) at Lulea Institute of Technology, Sweden.
  • Mentored an “India Science and Research Fellowship (ISRF) – International Fellowship for SAARC Countries” Dec 2021 – June 2022.
  • Membership of International Society for Extracellular Vesicles, 2021-2022.
  • Saroj Kumar, Fredrik Nikolajeff. "First meeting for Medical Technology", Researchers and teachers from Sweden, Germany and India met for the first time at Luleå University of Technology, Sweden in Aug 2021. https://www.ltu.se/org/hlv/Nyheter/Forsta-traffen-for-medicinsk-teknik-1.210670?l=en
  • Reviewer of Department of Science and technology (DST) core proposal, 2021.
  • Saroj Kumar, Fredrik Nikolajeff: Early diagnosis of Parkinson's disease. IVA's (Royal Swedish Academy of Engineering Sciences) 100 list 2020: From knowledge to sustainable competitiveness. https://www.iva.se/projekt/research2business/ivas-100-lista-2020/
  • Established and developed “Infrared Spectroscopy and Imaging Laboratory” at Uppsala University, Sweden.
  • Invited by MedTech4Health, Uppsala to participate in Indo-Swedish Health Year 2019 at Swedish Embassy, India.
  • Joint Secretory; 19th Biennial Conference of Association of Gerontology, 2019.
  • Expert reviewer of “Polish National Grant Application”, Poland, 2019.
  • Mobility for Growth, Project leader, VINNOVA-VINNMER (2015) Swedish research, Sweden.
  • CIHR-THRUST postdoctoral fellow (2014), Canadian light source, Canada.
  • Brains back to Brussels (2011), postdoc (only given to exceptional cases non-Belgium).
  • Postdoctoral grant from National fund for scientific research, Belgium (2011).
  • Swedish postdoctoral grant (2011) to pursue postdoc studies.
  • Marie Curie International outgoing fellowship for career development (2011), the proposal was placed on the reserve list.

Selected Publications/Patents (Last 5 years)

PATENTS:

  • Saroj Kumar, Simran Rastogi and Komal Rani. 2022. “A Composition for Isolating Exosomes and Method Thereof”. Patent Application Number: 202211022537.
  • Gyan Prakash Modi, Himanshu Rai, Rishabh Singh, Saroj Kumar, Gauri Shankar, Brijesh Singh, Sarika Gupta, Saripella Srikrishna, Sairam Krishnamurthy. 2022. “An Imaging Probe for Detection of Key Biomarkers in Alzheimer Disease”. Reference/identification number of the patent: 6457IN034.
  • Gyan Prakash Modi, Yash Pal Singh, C. Praveen Kumar, Meenu Yadav, Gauri Shankar, Gourav Singh, Saroj Kumar, S Srikrishna. 2021. “A multifunctional diarylurea-hydroxyamidine based compound for treatment of Alzheimer’s disease”. TEMP/E-1/1680/2021-DEL. Patent App. No: 202111001482; Ref. No. P.2116.IN. (Patent Filed Jan 2021).

PUBLICATIONS: (Last 5 years):

  • Priya Kumari Gorai, Simran Rastogi, Prahalad Singh Bharti, S Shivani, Priyanka Soni, Harshit Jain, Seema Singh, Shipra Agarwal, Sujoy Pal, Tapas Chandra Nag, Renu Dhingra, Mehar Chand Sharma, Rakesh Kumar, Fredrik Nikolajeff, Saroj Kumar*, Neerja Rani*. 2023. “Plasma-derived extracellular vesicles reveal pancreatic neuroendocrine tumors.” Molecular Oncology. (Under Review, MOLONC-23-0074) (IF: 7.449)
  • Abhay Mishra, Prahalad Singh Bharti, Fredrik Nikolajeff, Saroj Kumar*. 2023. “A Tale of Exosomes and their Implication in Cancer”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. (Under Review, BBACAN-D-23-00038) (IF: 11.414)
  • Simran Rastogi, Komal Rani, Vaibhav Sharma, Prahalad Singh Bharti, Krishna Deo, Veena Jain, Aditi Nanda, Saroj Kumar*, Dheeraj Kumar Koli*. 2023. “Osteogenic markers in perimplant crevicular fluid (PICF) in immediate and delayed loaded dental implants: A randomized controlled trial”. Clinical Implant Dentistry and Related Research. (Under Revision, CID-22-290.R2) (IF: 4.259)
  • Simran Rastogi, Komal Rani, Sanskriti Rai, Rishabh Singh, Vaibhav Sharma, Prahalad Singh Bharti, Vrinda Kapoor, Poorvi Vishwakarma, Shivaji Gholap, Krishna Inampudi, Gyan Prakash Modi, Neerja Rani, Madhavi Tripathi, Achal Srivastava, Roopa Rajan, Fredrik Nikolajeff, Saroj Kumar*. 2023. “Fluorescence tagged salivary exosomes as a nano tool in early diagnosis of Parkinson’s disease”. Translational Neurodegeneration. (Under Revision, TNEU-D-22-00393R1) https://doi.org/10.21203/rs.3.rs-1621589/v1 (IF: 9.88)
  • Vaibhav Sharma, Fredrik Nikolajeff, Saroj Kumar*. 2023. “Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases”. Translational Neurodegeneration (Accepted, TNEU-D-22-00341) (IF: 9.88)
  • Sunil Kumar, Faheem Abbas, Iqra Ali, Manoj K Gupta, Saroj Kumar, Deepak Kumar. 2023. Integrated network pharmacology and in-silico approaches to decipher the pharmacological mechanism of Selaginella tamariscina in the treatment of non-small cell lung cancer. Phytomedicine Plus. (Accepted, PHYPLU_100419)
  • Vaibhav Sharma, Saptamita Paul Choudhury, Saroj Kumar, Fredrik Nikolajeff. 2023. “Saliva based diagnostic methodologies for a fast-track detection of autism spectrum disorder: A mini-review”. Frontiers in Neuroscience. 2023;16. https://doi.org/10.3389/fnins.2022.893251 (IF: 5.152)
  • Himanshu Rai, Sarika Gupta, Saroj Kumar, Jian Yang, Sushil K Singh, Chongzhao Ran, Gyan Modi. 2022. “Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid Beta and Tau Aggregates in Alzheimer’s Disease”. ACS Journal of Medicinal Chemistry (Accepted) https://doi.org/10.1021/acs.jmedchem.1c01619 (IF: 7.446)
  • Vaibhav Sharma, Saptamita Choudhury, Srijon Sen, Sarika Bano, Kapil Suchal, Saroj Kumar, Fredrik Nikolajeff, and Sanjay Dey. 2022. “Altered Neural Cell Junctions and Ion-channels Leading to Disrupted Neuron Communication in Parkinson’s Disease”. NPJ Parkinson's Disease 8 (1): 66. https://doi.org/10.1038/s41531-022-00324-9 (IF: 9.304)
  • Rajkumar Kulandaisamy, Tushar Kushwaha, Anu Dalal, Vikas Kumar, Deepa Singh, Kamal Baswal, Pratibha Sharma, Kokkula Praneeth, Pankaj Jorwal, Sarala R Kayampeta, Tamanna Sharma, Srinivas Maddur, Manoj Kumar, Saroj Kumar, Aparoy Polamarasetty, Aekagra Singh, Deepak Sehgal, Shivajirao L Gholap, Mohan B Appaiahgari, Madhumohan R Katika, Krishna K Inampudi. 2022. “Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in Vitro Studies.” Frontiers in Microbiology 13: 877813. https://www.frontiersin.org/article/10.3389/fmicb.2022.877813 (IF: 5.640)
  • Nithin KV, Veena Jain, Dheeraj Kumar Koli, Saroj Kumar, Aditi Nanda. 2022. “Comparative Evaluation of Osteocalcin in Peri-Implant Crevicular Fluid and Radiographic Bone Loss in Immediate Loading and Delayed Loading Protocols: A Preliminary Split-Mouth Randomized Controlled Trial”. International Journal of Prosthodontics 35 (2): 174–180. http://dx.doi.org/10.11607/ijp.7489 (IF: 1.785)
  • Rastogi, Simran, Komal Rani, and Saroj Kumar*. 2021. “Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles.” Neuroscience Insights 16: 26331055211058690. https://doi.org/10.1177/26331055211058687 (IF: 2.640)
  • Singh Y, Kumar N, Khushbu P, Chauhan BS, Shankar G, Kumar S, Singh G, Srikrishna S, Garg P, Singh G, Rai G, Modi GP*. 2021. Exploration of Neuroprotective Properties of Naturally Inspired Multifunctional Molecule (F24) Against Oxidative Stress and Amyloid β Induced Neurotoxicity in Alzheimer's Disease Models. ACS Chemical Neuroscience 13 (1): 27-42. https://doi.org/10.1021/acschemneuro.1c00443 (IF: 5.780)
  • Yash Pal Singh, Himanshu Rai, Gourav Singh, Gireesh Kumar Singh, Sunil Mishra, Saroj Kumar, S. Srikrishna, and Gyan Modi. 2021. “A Review on Ferulic Acid and Analogs Based Scaffolds for the Management of Alzheimer’s Disease.” European Journal of Medicinal Chemistry 215: 113278. https://doi.org/10.1016/j.ejmech.2021.113278 (IF: 7.088)
  • Simran Rastogi, Vaibhav Sharma, Prahalad Singh Bharti, Komal Rani, Gyan P. Modi, Fredrik Nikolajeff, and Saroj Kumar*. 2021. “The Evolving Landscape of Exosomes in Neurodegenerative Diseases: Exosomes Characteristics and a Promising Role in Early Diagnosis.” International Journal of Molecular Sciences 22 (1): 440. https://doi.org/10.3390/ijms22010440 (IF: 6.208)
  • Komal Rani, Simran Rastogi, Poorvi Vishwakarma, Prahalad Singh Bharti, Vaibhav Sharma, Km Renu, Gyan P. Modi, Venugopalan Y. Vishnu, Prashun Chatterjee, Aparajit Ballav Dey, Fredrik Nikolajeff, and Saroj Kumar*. 2021. “A Novel Approach to Correlate the Salivary Exosomes and Their Protein Cargo in the Progression of Cognitive Impairment into Alzheimer’s Disease.” Journal of Neuroscience Methods 347: 108980. https://doi.org/10.1016/j.jneumeth.2020.108980 (IF: 2.987)
  • Lakshay Malhotra, Harsh K. V. Goyal, Sunita Jhuria, Kapil Dev, Saroj Kumar, Manoj Kumar, Punit Kaur, and Abdul S. Ethayathulla*. 2021. “Curcumin Rescue P53Y220C in BxPC-3 Pancreatic Adenocarcinomas Cell Line: Evidence-Based on Computational, Biophysical, and in Vivo Studies.” Biochimica et Biophysica Acta (BBA) - General Subjects 1865 (2): 129807. https://doi.org/10.1016/j.bbagen.2020.129807 (IF: 4.117)
  • Simran Rastogi, Komal Rani, Fredrik Nikolajeff, and Saroj Kumar*. 2020. “Finding a Novel Method to Understand the Role of Salivary Exosome in Progression of Cognitive Impairment to Alzheimer’s Disease.” Alzheimer’s & Dementia 16 (S4): e041920. https://doi.org/10.1002/alz.041920 (IF: 21.566)
  • Vaibhav Sharma, Simran Rastogi, Kaushal Kumar Bhati, Alagiri Srinivasan, Ajoy Roychoudhury, Fredrik Nikolajeff, and Saroj Kumar*. 2020. “Mapping the Inorganic and Proteomic Differences among Different Types of Human Teeth: A Preliminary Compositional Insight.” Biomolecules 10 (11): 1540. https://doi.org/10.3390/biom10111540 (IF: 6.064)
  • Rajkumar Kulandaisamy, Tushar Kushwaha, Vikas Kumar, Soumya De, Saroj Kumar, Santosh Kumar Upadhyay, Manoj Kumar, Krishna K. Inampudi*. 2020. "Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies". International Journal of Biological Macromolecules 159: 877-885. https://doi.org/10.1016/j.ijbiomac.2020.05.133 (IF: 6.953)
  • Vaibhav Sharma, Alagiri Srinivasan, Fredrik Nikolajeff, Saroj Kumar*. 2020. "Biomineralization Process in Hard Tissues: The Interaction Complexity within Protein and Inorganic Counterparts". Acta Biomaterialia 120: 20-37. https://doi.org/10.1016/j.actbio.2020.04.049 (IF: 10.633)
  • Komal Rani, Mitali Tyagi, Mohit Majumdar, Akanksha Singh, Annaian Shanmugam, Krishna Dalal, Manoj Pillai, Gourinath Samudrala, Saroj Kumar, Alagiri Srinavasan*. 2020. “Accelerated identification of serine racemase inhibitor from Centella asiatica". Scientific Reports 10 (1): 4640. https://doi.org/10.1038/s41598-020-61494-1 (IF: 5.134)
  • Javeed Ahmad, Mohd Khubaib, Javaid Ahmad Sheikh, Rita Pancsa, Saroj Kumar, A. Srinivasan, M. A. Al-Dosary. 2020. "Targeting the Hsp90 Inhibitors Against SARS-CoV-2 Protein: A Computational Study". Virus Research 290: 198173. https://doi.org/10.1016/j.virusres.2020.198173 (IF: 4.034)
  • Rakesh Kumar, Maheswari S, Sneha R. Kumari, Sharanya S. S., and Saroj Kumar*. 2020. “Characterization of Exosomes from Saliva and Their Cargo in Human Papilloma Virus Infected Patients.” Journal of Clinical Medicine 9 (11): 3584. https://doi.org/10.3390/jcm9113584 (IF: 4.242)
  • Yadav J.P., Kumar S. 2019. “Endoplasmic Reticulum Stress Response in the Pathophysiology of Neurodegenerative Diseases”. Reviews in the Neurosciences 30: 521-532. https://doi.org/10.1515/revneuro-2019-0030 (IF: 1.747)
  • Sumesh S., Garg S., Kumar S., Pandey D., Yadav R., Sahai S., Shrivastava S., and Tiwari M. 2019. “Association between the function of mitochondrial dynamics and autophagy in neurodegenerative diseases”. Journal of Molecular Neuroscience 67: 322-332. https://doi.org/10.1007/s12031-019-01377-2 (IF: 3.141)
  • Sunil K, Ashok Kumar, Ranjan Roy, Sumesh S, Deepak N. 2019. “Biochemical Alterations of the Plasma Membrane in Alzheimer's Disease”. Journal of Alzheimer's Disease 72(3): 877-883. https://doi.org/10.3233/JAD-190485 (IF: 5.982)
  • Gaurav R. Kumar, Vishal Srivastava, Vaibhav S. Choudhury, Shankar G. Kumar, Saroj Kumar, Meenakshi. 2018. “Drug Repositioning: A Revolutionary Approach for the Treatment of Alzheimer’s Disease”. Future Medicinal Chemistry 10(8): 877-883. https://doi.org/10.1016/j.jom.2018.08.123 (IF: 6.510)
  • Deepak S, Saroj K, Sachin S, Suneel R, Krishna G., Swati S, Renu D, Komal S. 2018. “Neurodegenerative Diseases and Potential Role of Exosomes in Their Diagnosis.” Cellular and Molecular Neurobiology 38(4): 597-608. https://doi.org/10.1007/s10571-017-0545-5 (IF: 5.378)