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Research (Endocrinology, Metabolism & Diabetes)

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RESEARCH

Funded projects

Ongoing

  1. SARS-CoV-2 infection (COVID-19) related clinical outcomes among people with and without diabetes and/or hypertension in India - A hospital-based observational study, Nikhil Tandon, ICMR, 1 ½, 2021, 2022, 45,21,300
  2. Comparison of Seroprevalence of SARS-CoV-2 among people with and without diabetes and/or hypertension among existing cardiovascular community cohort in National Capital Region (NCR) of Delhi, Nikhil Tandon, ICMR, 1 ¼, 2021, 2022, 58,516,50
  3. Integrated Tracking Referral, and Algorithmic Management (I-TREC) System for Hypertension and Diabetes Institution, Nikhil Tandon, NIH, USA, 5, 2017, 2022, $649,748
  4. Development of Phase II Clinical Trial for an Investigational New Drug, Nikhil Tandon, Torrent Pharma, 7, 2014, 2022, 84,53,212
  5. ICMR – Young Diabetes Registry (YDR) & YDR cohort – Phase III, Nikhil Tandon, ICMR, 3, 2020, 2023, 27,026,286
  6. Centre for Advanced Research and Excellence (CARE) in Young Diabetes, Nikhil Tandon, ICMR, 5, 2019, 2024, 1,04,95,880
  7. SOUL - Semaglutide cardiovascular outcomes trial in patients with type 2 diabetes, Nikhil Tandon, Novo Nordisk India Pvt Ltd., 5, 2019, 2024, 30,00,000
  8. Long-term effects of semaglutide on diabetic retinopathy in subjects with type 2 diabetes (FOCUS), Nikhil Tandon, Novo Nordisk India Pvt Ltd., 5, 2019, 2024, 27,50,000
  9. Changing diabetes in children, Nikhil Tandon, Novo Nordisk India Pvt Ltd, 11, 2012, 2023, 25,00,000
  10. To develop a strategy for postpartum follow-up of women with a history of gestational diabetes mellitus by using the right test and frequency of testing and developing a patient-centric approach after incorporating their views, Nikhil Tandon, Lupin Ltd., 5, 2018, 2023, 40,41,400
  11. Vitamin D deficiency and bone microarchitecture in asymptomatic healthy Indians: Exploring the functional significance of low serum 25(OH)D and high PTH, Ravinder Goswami, DBT, 4, 2019, 2023, 76,00,000
  12. One alpha hydroxyl vitamin D versus 1,25 dihydroxy vitamin D for achieving optimal calcemic and phosphatemic control in patients with idiopathic hypoparathyroidism, Ravinder Goswami, ICMR, 2, 2021, 2023, 31,20,076
  13. To Study the prevalence of Primary Aldosteronism among the patients of essential hypertension., Awarded to UG students; Mentor – Rajesh Khadgawat, AIIMS UG Research Grant, 1, 2021, 2022, 2,00,000
  14. A randomised, multinational, active-controlled (open-labelled), dose-finding (double-blinded), parallel group trial investigating efficacy and safety of once-weekly NNC0195-0092 treatment compared to daily growth hormone treatment in growth hormone treatment-naïve pre-pubertal children with growth hormone deficiency, Rajesh Khadgawat, Novo Nordisk, 6, 2017, 2022, 30,00,000
  15. A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Effect of Efpeglenatide on Cardiovascular Outcomes in Type 2 Diabetes Patients at High Cardiovascular Risk, Rajesh Khadgawat, Sanofi Aventis, 5, 2018, 2023, 20,00,000
  16. A trial comparing the effect and safety of once-weekly dosing of somapacitan with daily Norditropin® in children with growth hormone deficiency, Rajesh Khadgawat, Novo Nordisk, 5, 2018, 2023, 10,00,000
  17. Efficacy and safety of oral semaglutide versus oral placebo both in combination with metformin and/or basal insulin in children and adolescents with type 2 diabetes, Rajesh Khadgawat, Novo Nordisk, 3, 2020, 2023, 25,00,000
  18. To study the effect of changes in growth hormone status on metabolomic profile of human subjects, Rajesh Khadgawat, ICMR, 3, 2021, 2023, 29,00,000
  19. Molecular Genomics of congenital Growth Hormone Deficiency and GH sensitivity, Rajesh Khadgawat, Own/Self, 3, 2021, 2023, 0
  20. A 26-week, randomised, multicentre, open-label, active-controlled, parallel group, two-armed, treat-to-target trial investigating the effect on glycaemic control and safety of treatment with once-weekly Insulin Icodec compared to once-daily Insulin Degludec, both in combination with Insulin Aspart in adults with type 1 Diabetes, with a 26-week extension investigating long-term safety, Rajesh Khadgawat, Novo Nordisk, 4, 2021, 2024, 34,95,400
  21. A dose-finding trial evaluating the effect and safety of once-weekly treatment of somapacitan compared to daily Norditropin® in children with short stature born small for gestational age with no catch-up growth by 2 years of age or older, Rajesh Khadgawat, Novo Nordisk, 5, 2020, 2025, 25,00,000
  22. An open-label multicentre roll-over study to assess long-term safety in patients with endogenous Cushing's syndrome who have completed prior Novartis-sponsored osilodrostat (LCI699) study and are judged by the investigator to benefit from continued treatment with osilodrostat, Viveka P. Jyotsna, Novartis/IQVA, 6, 2019, 2024, 30,00,000
  23. To evaluate the effectiveness of a lifestyle intervention program in overweight/obese women [within two years of last childbirth] when delivered to them along with their spouse as compared to them alone: Two arms parallel Randomized Control Trial, Yashdeep Gupta, ICMR, 3, 2019, 2022, 47,00,000
  24. Metabolic profiling as per glycemic status [normoglycemia/prediabetes/diabetes] in women with a history of gestational diabetes mellitus (GDM) - A cross-sectional study, Yashdeep Gupta, AIIMS-THSTI, 2, 2020, 2022, 20,00,000
  25. To generate normative data using a continuous glucose monitoring system for glycemia in pregnancy at 24 to 32 weeks of gestation in women defined as normal by IADPSG (International Association of Diabetes and Pregnancy Study Groups) criteria, Yashdeep Gupta, ICMR, 3, 2021, 2024, 45,00,000

Departmental Projects (including thesis/dissertations)

Ongoing

  1. Etiological and clinical profile of patients with ectopic ACTH syndrome: Ambispective study
  2. Pattern of islet antibodies and their persistence in Type 1 Diabetes patients from North India
  3. Vitamin D status and its functional significance
  4. Molecular aspects in the pathogenesis of Basal ganglia calcification in hypoparathyroidism
  5. Characterization of Neuroendocrine Tumors with Ga68-DOTANOC PET/CT and F18-FDG PET/CT and compare results with histopathology
  6. Assessing Indian vegetarian diets with respect to their “potential protective impact” on cardio-metabolic health of urban adults in Delhi
  7. To study the effect of personality on diet quality & academic performance among adolescents: a comparison between boys & girls
  8. To study the prevalence of primary aldosteronism in high-risk subjects with hypertension
  9. To study the response to vitamin D treatment in obese, overweight, and normal BMI, vitamin D deficient Indian children aged 5 to 12 years—an open-labeled randomized intervention study
  10. To study the management outcomes in patients with primary aldosteronism
  11. Evaluation and characteristics of multiple Endocrine neoplasia in cases with primary hyperparathyroidism admitted in Endocrine ward over the last 10 years: an ambispective study
  12. Etiological and clinical profile of non-diabetic hypoglycemia: an ambispective study
  13. To study the clinical spectrum/profile of MEN syndrome patients in North India

Collaborative projects

Ongoing

  1. Pathogenesis of primary parathyroid adenoma, Departments of Pathology, Forensic Medicine, and Anatomy
  2. Correlation of Levator-Muller’s Complex Thickness on UBM with Clinical Response to Botulinum Toxin A injection in Patients with Thyroid-related severe Retraction of Upper Eyelid, Department of Ophthalmology, AIIMS
  3. A Prospective study to determine early predictive factors of hypocalcemia in patients undergoing total or completion thyroidectomy (2021-2023), Department of Otorhinolaryngology, AIIMS
  4. Study to quantify the burden of insulin resistance in breast cancer women and its relation with other known prognostic and predictive factors of breast cancer (2021-2023), Department of Surgery, AIIMS
  5. A randomized control trial to compare the safety and outcome of trans-oral vestibular and axillo-breast approach for endoscopic hemithyroidectomy in patients with benign thyroid swellings (2021-2024), Department of General Surgery, AIIMS
  6. Evaluation of the role of platelet-rich plasma in healing of chronic diabetic and peripheral arterial disease ulcers as compared to standard medical care: a randomized control study (2021-2024), Department of Surgery, AIIMS
  7. Effect of benfotiamine as an adjuvant drug on oxidative stress in patients with type 2 diabetes mellitus - a randomized double-blind placebo-controlled clinical trial (2021-2024), Department of Pharmacology, AIIMS
  8. Identification of genetic mutation in neuroendocrine tumors: Implication in diagnosis and management (2020-2023), Department of Anatomy, AIIMS
  9. Assessment of risk factors of Graves’ orbitopathy and predicting odds of dysthymic optic neuropathy in hyperthyroidism (2021-2024), Department of Ophthalmology, AIIMS